>200 genes 🧬 implicated in #SLE Complex indeed! And ▶️ 7 clusters of signalling pathways So we have to have many Rx options Ab patterns vary LN flares can have v diff pathways between Pts #LUPUS2025 @RheumNow Unravelling #LUPUS2026 https://t.co/LEKN363194

We are not (yet) in #SLE Getting 👇 Correct drug In right pt At right time At correct individual dose Even more problematic is in a renal bx - 2 glomeruli beside each other have v different cytokine expressions Unravelling #LUPUS2025 @RheumNow https://t.co/yGBvhFkPKY

Here’s who flares in #SLE least to most Persistently neg antiDNA Persistently + antiDNA conversion of neg to + antiDNA So are we over ordering antibodies in 1st 2 groups 🤷‍♀️ Unravelling #LUPUS2025 @RheumNow https://t.co/1Feau7f199

controversy re 👇 Monitoring for +Ro pregnant re #congenital #heart #block 87% Y echo is possibly too late No ideas if flourinated #steroids work But many thing we should do something Guidelines differ on recommendations Would fetal home HR be better #LUPUS2025 @RheumNow https://t.co/MY0oPjLnGs

An excellent presentation from Dr Pankti Mehta @PanktiMehta24 Re #Jaccoud’s With #IFN signature if #erosive IA - often + CCP / RF Vs nonerosive often +RNP @RheumNow #LUPUS2025 https://t.co/y6z4KbhCdy

The ANA pattern I hate #DFS Why Dense fine speckled should R/O #SLE But mimicking patterns that MAY Have #lupus AC-2 pattern mimickers ex AC-4 Machine learning models to help ▶️improved accuracy Fast saving hrs #Artificial #intelligence May Choi #LUPUS2025 @RheumNow https://t.co/9tk80ZOAWg

T2T in #SLE Lots of #rheumatologists do NOT do a validated measure so #DORIS remission may be over estimated But great algorithm for #lupus #Rx ⁦@RheumNow⁩ #LUPUS2025 https://t.co/mGoopRtK2F

T2T in SLE https://t.co/efTxDZz8Qd https://t.co/TvhOzCX34Q

Monitoring for #HCQ #retinal #toxicity 2 tests beyond visual fields are better than 1 OCT Etc But suggestion if low risk to do only every 5 yrs I don’t agree as risk ⬆️ w disease duration We do Annual fields and either OCT or retinal photography #LUPUS2025 @RheumNow https://t.co/TdPJ47jYEL

Subclinical #arthritis in #SLE Do we look for it? Should we care? Certainly seems to exist on #MRI hands More changes of course if tender joints Not sure of clinical relevance Optical imaging and POCUS was compared #LUPUS2025 @RheumNow ANCA Askanase presents