A multicenter study investigated the association between hydroxychloroquine (HCQ) dosage and COVID-19 mortality among hospitalized patients from multiple medical centers in China. The analysis focused on dose effects of HCQ on mortality.
This retrospective cohort includes 2,387 COVID-19 patients admitted to 12 hospitals in Hubei Province between January and June 2020. Patients are categorized into three groups: non-HCQ use (n=1,124), low-dose HCQ (β€600 mg/day, n=893), and high-dose HCQ (>600 mg/day, n=370). The primary endpoint is all-cause mortality.