Anti-PM-Scl connective tissue diseases - By Paul Breillat (Fellow in Internal Medicine, Paris, France) #connective #scleroderma #myositis #PMScl #InternistAcademy https://t.co/P727E4ddzz

✅ Probably one of my most important slides ⬇️ WHY IS MY #TREATMENT NOT WORKING (or not working enough) 😭 This is really a question we're dealing with everyday in #rheumatology when taking care of patients with #autoimmune and other rheumatic diseases 👍 https://t.co/osUPYSvuWf

This precipitous drop and current level is substantially worse than 21 peer countries https://t.co/NAEMjhs4j3 https://t.co/QhrZ1Xnwcr

Life expectancy for Americans is the lowest it's been since 1996. Read about the decline from @sheridan_kate https://t.co/QwkOmOt2Tp https://t.co/wavGjOv6q5

Statin Myalgias? Lancet metanalysis of 19 PCTs, >80K pts, @ 1yr, Statin caused a 7% increase in muscle pain or weakness (1·07; 1·04–1·10); thus 1 in 15 had myalgia due to statin (1/10 w/ high dose). After year 1, no signif excess in statin related myalgia https://t.co/6cRJQMymzM https://t.co/RTH56J4FD1

After historic drop in 2020 (COVID), life expectancy in USA dropped again, this time a full year to 76.1 years. The lowest since 1996 and the biggest 2-year decline in a century (dropping >2.5 yrs). To date, there have been 1,044,937 COVID deaths in USA https://t.co/aSgtw6MvGs https://t.co/0UKeyGujKe

Tapering biologics in Still's/Systemic JIA? 4 studies suggests after sustained inactive disease achieved, options include QOD (anakinra) dosing or dose reduction or interval prolongation (CAN & TCZ). KEY: early biologic starts https://t.co/33tjr65Gi0 https://t.co/fi6fc4NPgG

Study of Adult-onset Still's in Western Australia. Incidence = 0.22/100 000, prevalence = 2.4/100 000. AOSD had higher risk of previous liver disease (OR 2.67), serious infx (OR 4.36), joint replacement (OR 45.5), mortality not increased @ 1 & 5 yrs https://t.co/Wu0SQIMjWT https://t.co/Zvsdb2OR0y

Autoimmune Disease Augments Cardiovascular Risk A large UK database study suggests that young adults with autoimmune diseases have an associated increased risk for cardiovascular disease. https://t.co/TtiH9ZBkR8 https://t.co/jVZBk8l4XD

Review of cGAS/STING - enzyme cyclic GMP-AMP synthase. self genomic & mitochondrial DNA stimulates cGAS-->dimerizes & binds to the endoplasmic reticulum protein stimulator of IFN genes (STING), unleashing an inflammatory response https://t.co/g04v1S4PYJ https://t.co/SHeneZq4sd

Review of IL-1 inhibitors in recurrent idiopathic pericarditis. While Rilonacept is FDA approved (320 mg x1 then 160 mg sc/wk), anakinra (2 mg/kg/d or 100 mg/d), canakinumab and colchicine are used https://t.co/EQJV4qTFPj https://t.co/Rdkn4ljh0X