USPSTF recommends clinicians prescribe Statins for the primary CVD prevention in adults (40-75 yrs) w/ 1 or more CVD risk factors (ie, dyslipidemia, DM, HTN, smoking) & 10-year CVD risk of 10% or greater. Inflammatory dz is considered a CV risk enhancer https://t.co/XEaXqcCEg1 https://t.co/vEqEFV1kYv

Review of steroids & immunosuppressants on cancer outcomes in checkpoint inhibitor therapy - Steroid use "for irAEs may not have a large deleterious effect on overall survival" - DMARDs for irAE "a major drawback in the delay in the onset of response" https://t.co/YciXN4fdZQ https://t.co/oNgszsYNB8

MIRROR study lead to pegloticase (PEG) label change - adding MTX as Rx to reduced anti-PEG Abs. Based on 14 refractory gout pts given MTX 15mg/wk (w/ folate) and then PEG IV: 3 nonresponders, 1 dropped out, 10 responded/stayed on Rx x 52 wks w/ less ADAbs https://t.co/4Hew7zVu7J https://t.co/za9hQ8Plnl

Prospective study of 124 adults hospitalized w/ acute MSK trauma saw good outcomes in 23% @6 mos & 61% @12 mos. Worse outcomes assoc w/ posttraumatic stress Sxs (OR 2.09), pain intensity (2.87), # fractures (2.79)& pain extent (4.67) https://t.co/ubuyWCBFgU https://t.co/ZfNGUQ1i0e

Influenza Vaccination Recommendations The CDC has published an update to the recommendations from the Advisory Committee on Immunization Practices (ACIP) on the use of seasonal influenza vaccines in the United States for the 2022-23 season. https://t.co/6V21XZUsqX https://t.co/ln9bqta6UT

Phase 2 RCTs are evaluating TLR 7 & TLR 8 blockade in SLE - BMS has afimetoran and Merck has enpatoran (both blocking TLR7/8) https://t.co/lSvnAkRvxB https://t.co/i7ZORYyKHP

The prospective CARDIA cohort study studied 2110 adults (38 - 50 yrs) for 10+ yrs and showed those taking >7000 steps/day had a 50% to 70% lower risk of mortality (vs those taking <7000 steps/day). https://t.co/lE152z8vTw https://t.co/hjfnCN4bno

ALL-HEART study presented in Barcelona at ESC Congress 2022 showed that allopurinol given to 5,721 older adults without gout, failed to reduce # nonfatal myocardial infarction, nonfatal stroke or cardiovascular death in ischaemic heart Dz pts https://t.co/I0dFXQa6Ao https://t.co/8IevQ4uwUY

Weight Loss Slows Knee OA Progression Declines in body mass index (BMI) were linked with slower worsening of knee osteoarthritis (OA), according to data from three large longitudinal cohort studies. https://t.co/jJlSTdBdXT https://t.co/9mPJiVT9nE

Axial Psoriatic Arthritis and Ankylosing Spondylitis with Psoriasis A cohort analysis from Toronto suggests that axial psoriatic arthritis (PsA) is distinctly different from axial ankylosing spondylitis (AS) with psoriasis. https://t.co/8bAoqp79Mg https://t.co/K2Z1LwPTiS

Cochrane review of Stem cell transplantation in systemic sclerosis (3RCTs w/ 125 pts). Non‐myeloablative & myeloablative selective HSCT had moderate evidence for improved survival, skin thickness & function. But these had high Serious AE rates. https://t.co/VKciXY0klN https://t.co/LdMu3RrlZK