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Norway study 1558 chart-reviewed SLE cases; 797 were new-onset SLE from 1999 to 2017. During this period the annual SLE incidence rates fell; mostly pronounced in women 50-59 yrs (fell 3.4 to 1.1 per 100K) - paralleled by 74% reduction menopausal HRT https://t.co/zYkXAnEcOI https://t.co/oaz9t65zZy
Dr. John Cush @RheumNow ( View Tweet )
1 month ago
Australian study shows self-reported difficulties w/ ambulation (limited<=1 km) had a higher risk of hip and spinal fractures (32% to 219% more)/ Included 239 000 adults >45 yrs https://t.co/IWvKmPc2t8 https://t.co/CDYDzhMUoa
Dr. John Cush @RheumNow ( View Tweet )
1 month ago
When Meningitis Strikes Twice Amanda Moyer, MD, presents her poster at RWCS 2024. https://t.co/er2E2XnrZZ https://t.co/vwDopOLPRH
Dr. John Cush @RheumNow ( View Tweet )
1 month ago
With New Medications Come New Myopathies Alexia Hwang, MD, presents her poster at RWCS 2024. https://t.co/BjYxKk2QlW https://t.co/vDA0dllMQz
Dr. John Cush @RheumNow ( View Tweet )
1 month ago
Immunosuppression Increasing Dr. Jack Cush reviews the news and journal reports from the past 2 weeks on https://t.co/V10S4oVFsv; but begins with a discussion of what constitutes "immunosuppression" and how it applies to our patients. https://t.co/KvZIiKowox https://t.co/cbBYydVQbB
Dr. John Cush @RheumNow ( View Tweet )
1 month ago
Single center study of 163 pts (mostly RA) Rx w/ tocilizumab found 41 hospitalized & 49% for serious infx. SIE were more common w/ eosinopenia (EC < 0.05 g/L; avg (0.06 vs 0.20 g/L) & low ratio EC/NC ratio (× 1000 < 11.8) (median (6.54 vs 48.50). https://t.co/88sbHBIhXt https://t.co/6wUeqSbVxx
Dr. John Cush @RheumNow ( View Tweet )
1 month ago
No clear link between weather & MSK symptoms There is a belief that changes in weather conditions, such as impending rain or temperature, can trigger or worsen muscle and joint pain but Australian researchers have found no clear pattern between the two. https://t.co/V3rfCTWRBQ https://t.co/eFdZH4LoNA
Dr. John Cush @RheumNow ( View Tweet )
1 month ago
CD19 CAR T-Cell Therapy in Autoimmune Disease The NEJM has published the results of CD19 B cell depletion (by CAR-T cell therapy) in autoimmune disease patients, demonstrating it to be feasible, safe, and efficacious. https://t.co/ym3pAsI5Sf https://t.co/AnfKOISscV
Dr. John Cush @RheumNow ( View Tweet )
1 month ago
RA BIOBADASER registry study of 1128 patients going on ts/bDMARD found 107 (9.3%) w/ multimorbidity (Charlson Comorbidity index ≥ 3). Multimorbid RA were older, more SJC & signif higher DAS28; ts/bDMARD retention rate equal groups https://t.co/am4Uoccla9 https://t.co/P7Ae2Jal2e
Dr. John Cush @RheumNow ( View Tweet )
1 month ago
Feb 2024 EMA meeting approved biosimilar ustekinumab (Pyzchiva) for adult/pediatric psoriasis; psoriatic arthritis; UC/Crohn's. & also approved generic Apremilast Accordfor the treatment of psoriatic arthritis, psoriasis, and Behçet disease https://t.co/Cu9f4qQjgP https://t.co/qmH3ZkfReN
Dr. John Cush @RheumNow ( View Tweet )
1 month ago
Congratulations to Drs. David Felson Tuhina Neogi of Boston University in being awarded a U19 5 yr grant to fund Novel Insights into Osteoarthritis, Pain and Function: The Multicenter Osteoarthritis (MOST) Study. https://t.co/fGU9Zk2ECs https://t.co/dtT0hu7aA1
Dr. John Cush @RheumNow ( View Tweet )
1 month ago
MMPs play pathogenic role in RA-ILD. Multicenter VA study of 2,312 RA pts, 96 had prevalent ILD & Incident ILD developed in 130 (IR 7.5/1,000PY). High MMP-7 increased ILD (adj OR 3.78) & incident ILD (adj HR 2.33). Higher MMP-9 did same https://t.co/3i49TsAQbt https://t.co/RA6Fu2jPeE
Dr. John Cush @RheumNow ( View Tweet )
1 month ago