Tweets
FDA approves Abbvies new JAK1 inhibitor - upadacitinib (named Rinvok) Package insert - indicated for use in mod. to severely active RA not resp to MTX (do not combine w/ other JAKS, biologics). 15 mg qd. Warning for VTE, DVT. https://t.co/9KODynuWKC https://t.co/zRpeiaiTNS
Dr. John Cush @RheumNow ( View Tweet )
6 years 11 months ago
Chance over metrics? If your metrics are not predictive, then you have failed metrics and the opportunity to refine, Change or rethink. Should you randomly chose a drug from equivalent drugs or use data to make a better choice? https://t.co/a7GibSmOWv
Dr. John Cush @RheumNow ( View Tweet )
6 years 11 months ago
UT Southwestern Super Hepatologist Dr Will Lee lecturing on drug induced liver injury (DILI) shows DILI is not increase with NASH/NAFLD https://t.co/1Kt7hFhUx1
Dr. John Cush @RheumNow ( View Tweet )
6 years 11 months ago
Nurses' Health Study II shows high gluten intake is not assoc w/ a greater risk of Psoriasis (HR 1.15;0.98-1.36), Psoriatic arthritis (HR 1.12;0.78-1.62) or Atopic dermatitis (HR 0.91; 0.66-1.25); 85,185 Pso, 85,324 PsA & 63,443 atopic dermatitis patients. https://t.co/P1eWGZZqKl
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Dr. John Cush @RheumNow ( View Tweet )
6 years 11 months ago
Kaiser study from N California shows increasing trend in cannabis use w/ #pregnancy. Sample of 367 403 pregnancies in 276 991 women between 2009-18, cannibis use rose from 1.95% to 3.38% - ?increasing acceptance & decreasing perceptions of harms? https://t.co/VdOPrCsZQ1
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Dr. John Cush @RheumNow ( View Tweet )
6 years 11 months ago
Ah yes...lifestyle is certainly a BIG issue in RA, especially when there's a poor outcome. Besides life in the fast lane - other bad advice for RA - Take It Easy, Take It to the Limit
& Tequila Sunrise. Good Advice? Take it easy! https://t.co/uKkRveDYzp
Dr. John Cush @RheumNow ( View Tweet )
6 years 11 months ago
Cross sectional analysis of ~3000 and meta-analysis (14 studies) finds #gout has a higher risk of hypothyroidism, esp in female gout pts (OR=2.44;1.15-5.17); Metaanalysis ^risk hypothyroidism in gout (OR=1.51) and hyperuricemic pts (OR=1.34) https://t.co/1w3xfHqryJ
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Dr. John Cush @RheumNow ( View Tweet )
6 years 11 months ago
Lilly announces the results of its phase 4 trial comparing Taltz (IL-17) to Tremfya (IL-23) in mod-severe plaque psoriasis. Taltz had superior skin clearance (PASI 100) at week 12, better PASI 75 at week 2 and PASI 90 at weeks 4 and 8. https://t.co/GzfZoepUrK
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Dr. John Cush @RheumNow ( View Tweet )
6 years 11 months ago
"WAR on RA - Part 4: Desperado" is featured on RheumNow. Why the Eagles and Glenn Fry's death should inspire us to better, greater, more and other superlatives in RA. https://t.co/dgShcQpWHP
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Dr. John Cush @RheumNow ( View Tweet )
6 years 11 months ago
In GCA/Temporal arteritis, when do you start a DMARD/Biologic?
Dr. John Cush @RheumNow ( View Tweet )
6 years 11 months ago
Osteoarthritis Iniative study of 3053 #OA pts shows worsening in health related quality of life is most rapid with Female gender, higher BMI, smoking, knee pain, and lower income at baseline. Rapid progressors had higher risk of TKR (HR 6.2;CI 3.6–10.7) https://t.co/73OlM7ymH6
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Dr. John Cush @RheumNow ( View Tweet )
6 years 11 months ago
Case-control study using the UK Clinical Practice Research database examined 22677 RA pts. 1995–2017) exposed to antibiotics vs ~90K controls shows the risk of RA is 60% higher if Abx exposed (OR 1.60; 95% CI 1.51–1.68) - microbiome changes? https://t.co/ysfEXnRU3c
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Dr. John Cush @RheumNow ( View Tweet )
7 years ago
Nearly 30% of presurgical OA (Spine> Hip &Knee) used prescription opioids. Opioid use was greater w/ spine OA (vs knee), obesity, smokers, depression, greater pain, higher TJC, & concurrent use of other pain meds https://t.co/ns6JBB7BXU
Links:
Dr. John Cush @RheumNow ( View Tweet )
7 years ago
In GCA/Temporal arteritis, when do you start a DMARD/Biologic?
Dr. John Cush @RheumNow ( View Tweet )
7 years ago
"WAR on RA - Part 3: Useless Drugs". Old DMARDs were truly useless (gold, PCM, SSZ, HCQ) but are biologics, combinations, JAKs the answer? Watch here>> https://t.co/5wLDOnXJ1S or Listen on iTunes or SoundCloud https://t.co/SfPQ1sSXgi
Dr. John Cush @RheumNow ( View Tweet )
7 years ago
