Tweets
Korean National Health Insurance data compared the risk of CV events in 39,640 gout pts starting allopurinol or febuxostat. MACE incidence was 1.89 vs 1.84/100PY (HR 1.09; 0.90, 1.32) Thus, no significant difference in CV risk with these agents in Asians https://t.co/l316siAqd8
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Dr. John Cush @RheumNow ( View Tweet )
7 years 2 months ago
Alopecia areata pts have a higher risk of mortality assoc w/ self-harm, psychiatric dz (HR, 1.21) & smoking-associated malignant diseases including lung cancer (HR, 2.16), but not all cause mortality. Increases higher w/ Alopecia totalis/universalis. https://t.co/idVGmSTcRE
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Dr. John Cush @RheumNow ( View Tweet )
7 years 2 months ago
In a study of 678 first-degree relatives (FDRs) of RA patients and 330 osteoarthritis (OA) subjects, increasing age is associated with increasing positive results for the CCP3.1 and CCP-IgA test results - just like RF. https://t.co/0iwK0CjxUj
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Dr. John Cush @RheumNow ( View Tweet )
7 years 2 months ago
184 juvenile Fibromyalga pts randomized to PBO or duloxetine (30-->60mg/d) for 13wks. Those on duloxetine failed the primary endpoint - mean 24 hr change in Brief Pain Inventory (BPI), but more Cymbalt pts had 30% nd 50% BPI reductions https://t.co/EuyCRqKzN7
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Dr. John Cush @RheumNow ( View Tweet )
7 years 2 months ago
Japanese study 198 systemic sclerosis pts finds that higher skin thickness scores (modified Rodnan Skin Scores; mRSS) associated with higher risk of interstitial lung disease (P < 0.05), restrictive LDz(P < 0.01), and diffusion impairment (P < 0.05) https://t.co/PY4n6N5Ub9
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Dr. John Cush @RheumNow ( View Tweet )
7 years 2 months ago
FDA is seeking public input into CBD - cannabidiol - and will be holding a public hearing on CBD this friday May 31st. https://t.co/00MYFNESQ3
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Dr. John Cush @RheumNow ( View Tweet )
7 years 2 months ago
Risk factors for gouty tophi that ulcerate include: glucocorticoid overuse, tophi duration, and the number of tophi. Based on a chinese study of 105 tophaceous patients of whom 33 developed ulcerations https://t.co/rzYTFCb5jk
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Dr. John Cush @RheumNow ( View Tweet )
7 years 2 months ago
Research by Robinson and colleagues at Stanford show that mast cell inhibition or depletion significantly improved osteoarthritis in a mouse model. Mast cell driven tryptase increases inflammation, chondrocyte apoptosis, and cartilage breakdown https://t.co/LpgZUhDHvQ
Dr. John Cush @RheumNow ( View Tweet )
7 years 2 months ago
Dr. Madelaine Feldman's outstanding lecture on Drug Costs in America: The Bad, the Worse and The Despicable, is available for free at RheumNow Live On Demand at https://t.co/1jGiIQXvua. Check it out - you'll be glad you did. #rheumed #rheum https://t.co/MuNzooK8YB
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Dr. John Cush @RheumNow ( View Tweet )
7 years 2 months ago
FDA has approved the worlds most expensive drug - $2.1 million - Zolgensma (onasemnogene abeparvovec-xioi), a gene therapy for spinal muscular atrophy (SMA) that affects 1 in 11,000 newborns https://t.co/hHuymQ3sjV
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Dr. John Cush @RheumNow ( View Tweet )
7 years 2 months ago
Metanalysis suggests leflunomide in psoriatic disease is better at treating arthritis (PsA PsARC 77%) than skin disease (psoriasis PASI50 48% & PASI75 25%). Adverse events in 38% and 15% drop out rate. https://t.co/BIPNtYE6Tr
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Dr. John Cush @RheumNow ( View Tweet )
7 years 2 months ago
Harvinder S. Luthra, MBBS, Presented with the Albert Nelson Marquis Lifetime Achievement Award by Marquis Who's Who https://t.co/1aTy1axjXL
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Dr. John Cush @RheumNow ( View Tweet )
7 years 2 months ago
Large UK study shows central adiposity (waist circumference) signify increases risk of psoriasis and rheumatoid arthritis; not PsA. a cross-sectional study of the UK Biobank https://t.co/eKDpUodSR1
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Dr. John Cush @RheumNow ( View Tweet )
7 years 2 months ago
Lyrica is FDA approved for FM, Neuopathy & adjunctive Rx for partial-onset seizures; but recently failed to meet primary endpoint in a phase III RCT to prevent primary gen tonic-clonic seizures.- but is continuing to develop it for pediatric epilepsy. https://t.co/T9T0Kv1wkP
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Dr. John Cush @RheumNow ( View Tweet )
7 years 2 months ago
Prospective study of 4796 pts in Osteoarthritis Initiative shows metformin use in obese pts (BMI >30) was Assoc with significantly less medial cartilage loss (0.71% vs. 1.57%/yr) & a trend towards fewer knee replacements over 6 yrs (OR 0.30, p = 0.11) https://t.co/LD0jFWtSLM
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Dr. John Cush @RheumNow ( View Tweet )
7 years 2 months ago
