Tweets
Subclinical #arthritis in #SLE
Do we look for it?
Should we care?
Certainly seems to exist on #MRI hands
More changes of course if tender joints
Not sure of clinical relevance
Optical imaging and POCUS was compared
#LUPUS2025 @RheumNow
ANCA Askanase presents
Janet Pope @Janetbirdope ( View Tweet )
8 months ago
No Cancer Recurrence with Biologic DMARDs in RA
A prospective Danish rheumatoid arthritis (RA) registry study look at the risk of recurrence when a biological disease-modifying antirheumatic drugs (bDMARDs) was ued in patients with a a prior solid cancer (in remission) and https://t.co/T7G96cAlE6
Dr. John Cush @RheumNow ( View Tweet )
8 months ago
Tocilizumab vs. Methotrexate in Rheumatoid Arthritis
A large randomized rheumatoid arthritis (RA) clinical trial compared subcutaneous tocilizumab (TCZ) vs oral methotrexate (MTX) vs. the combination of subcutaneous TCZ and MTX, and showed that TCZ was superior to MTX, either https://t.co/AS8MJaujIE
Dr. John Cush @RheumNow ( View Tweet )
8 months ago
Why follow antiDNA and complements in
#lupus #nephritis #LN
#LUPUS2025 panel said
To detect flare
?to consider after 3 to 5 yrs of remission to taper Rx
?but not for early response to Rx
Just info from the panel with my opinion salted in
@RheumNow https://t.co/bFUfN0PsFF
Links:
Janet Pope @Janetbirdope ( View Tweet )
8 months ago
deep thoughts in #lupus
Is ‘better’ the enemy of #remission?
Is a complete renal response <50% at the end of contemporary #triple #therapy
Something to celebrate?
▶️Yes better than old #SoC but a bit sobering
We need RCTs that radically change paradigm
#LUPUS2025 @RheumNow
Janet Pope @Janetbirdope ( View Tweet )
8 months ago
Who with +ANA will become #SLE
Mostly similar cytokine signature
But ⬆️IFN and
more innate immune changes
👇
In those who developed #lupus
? prediction & Prevention model in +#ANA people 🤷♀️
yr in review E Vital’s paper
#LUPUS2025 @RheumNow @ZahiTouma https://t.co/khpqRlH8Nk
Janet Pope @Janetbirdope ( View Tweet )
8 months ago
‘Oranges & green vegetables’
⬆️
#diarrhea in #MMF said Ana Malvar
bad #LN outcomes if #nonadherent
Good relationship with#HCP helps
#adherence
✅education to help deal with side effects
pts need to know
Why this Rx
?how long
S|E Rx
#ClinicalPearl
#LUPUS2025
@RheumNow https://t.co/RnFGwJSl1F
Janet Pope @Janetbirdope ( View Tweet )
8 months ago
Who does worse with #SLE
#nature vs #nurture
South American #lupus #registries
⬆️ activity
⬆️damage
⬇️age
⬇️SES
⬆️SLE #antibodies
#Gladel registry and others vs Europe
Environment >genetics 🤔
#LUPUS2025 #45poster @RheumNow
@gponsestel https://t.co/XjiXHAMuGm
Links:
Janet Pope @Janetbirdope ( View Tweet )
8 months ago
do’s & don’t #Lupus #nephritis
❎
Don’t sequential monotherapy
▶️ use #MMF + #biologic or #CNI
✅
Do a #biopsy
➡️ need to know
#dx
#px
Do target LOW proteinuria
Do treat comorbidities
Lipids
HTN
Fluids
BMI
?mood
No #NSAIDs
Do limit #pred
#SGLT2i
@RheumNow #LUPUS2025 https://t.co/D0vHQXYTvZ
Links:
Janet Pope @Janetbirdope ( View Tweet )
8 months ago
Impt predictors of
#neuropsychiatric #SLE
#LUPUS2025 @RheumNow
No major predictors
But if explanation of other conditions ex
Past #cvA
#ischemic events
Doesn’t have to have
➡️Active systemic ##Lupus
➡️ ?ribosomalP
+Abs described in #CNS lupus
A real headache! https://t.co/iuWfB454EN
Janet Pope @Janetbirdope ( View Tweet )
8 months ago
‘It’s #Lupus, it’s all in your head!’
➡️ Some patients with #SLE have heard this from others
At #LUPUS2025 in a packed session on #CNS lupus
#Dx is tricky
40% of #neuropsychiatric lupus have NEGATIVE #brain #MRI
👇r/o
infarct/bleed
Infection
Rx #steroids
@RheumNow https://t.co/yU1olg0uZU
Links:
Janet Pope @Janetbirdope ( View Tweet )
8 months ago
Steroids prevention of #congenital #heart #block in +Ro
Mom
#DM #HTN #wt⬆️
Fetus
?no diff #cardiomyopathy
?learning &behavioural changes
Debate re screen #CHB
Most CHB are kids w CHB as mom is unknown to be +Ro
Angst w screening
High titre Ro Impt
@RheumNow #LUPUS2025
Janet Pope @Janetbirdope ( View Tweet )
8 months ago
