In this systematic review & metaanalyis by Dr. RFarhat et al, tacrolimus whole blood levels decrease in the 1st & 2nd trimesters then increase back to pre-pregnancy levels postpartum. Needs further studies to guide dose adjustment. @RheumNow #ACR24 abs1535 https://t.co/5MovzPJoFc

Dr. BDinneen et al reported predictors that can help screen axSpA pts w/o traditional CV RFs for carotid doppler utz: - shorter dse duration - no family hx of IHD - HLAB27+ - ⬆️ dBP, WHratio, ferritin, TC, LDL and TC:HDL ratio Small size, more data reqd @RheumNow #ACR24 abs1440 https://t.co/3pZxFmutJz

Andreasson et al. High intensity interval training provides greater improvements in exercise capacity than standard moderate intensity training in IIM. @RheumNow #ACR24 Abstr#1735 https://t.co/baj7Cq2QjO https://t.co/yiE1vuk2me

A#1748 Fracture incidence in RA - RISE registry Incidence rate of MOF, hip Fx by disease activity 50% did not have CDAI available IR 12 per 1000py hip, 43 for MOF High activity worst, low/mod similar, remission is best Supports remission is better than LDA @RheumNow #ACR24 https://t.co/78FCLemfZD

Interesting comparative effectivness study, TOFA vs calcineurin inhibitors in MDA5-dermato Expansion of prior publication @NEJM that used historical controls: https://t.co/AzA8ybCqYH Encouraging data for JAKs in this disease; need proper trials #ACR24 @RheumNow Abstr#1736 https://t.co/BHVMZLu6Ip

Wu et al. MDA5-DM. Propensity-score cohort study. 672 patients. Tofacitinib vs CNI. Primary outcome 1 year death or lung transplant. HR 0.70 favouring tofacitinib. @RheumNow #ACR24 Abstr#1736 https://t.co/A0aHhp1q9c https://t.co/LbutJDBllr

Can we do more to routinely assess fracture risk in RA? In RA pts ≥65, hip fracture & MOF are more common in pts with active disease, worse with higher disease activity ➡️Need better and more frequent bone health assessments in our RA pts Ab1748 #ACR24 @RheumNow https://t.co/whfnLnkpLd

A#1747 RA mortality by race/ethnicity Database study >200,000 pts had RA as contributing cause of death 5.1 ASMR in American Indian >>> all other groups No decr over time in grp, unlike other grps Odds of death 1.67 compared to white pop 10.8x higher in pts <44 #ACR24 @RheumNow https://t.co/nXLcQkQPu4

On now: The Great Debate - is MCTD a distinct clinical entity? @DrLisaCS reviews the history of MCTD classification criteria and its evolution Kasukawa criteria may be most sensitive in one cohort @RheumNow #ACR24 https://t.co/rDHafZVL1I