Tweets
"#RNL2024
Brittany Weber on Cardio-Rheumatology:
""Everything has changed"" on inflammation and CVD
- Canakinumab 150 mg v PBO HR 0.85, p =0.02
- Colchicine v PBO HR 0.69, P<0.001
2023: FDA approval for colchicine as 1st anti-inflammatory for reducing CV events
Dr. John Cush @RheumNow ( View Tweet )
1 week 5 days ago
#RNL2024 @RheumNow
@Bweber04
Asymptomatic Lupus has higher rate of atherosclerosis at all age grps
35-44 yo F with SLE: 50X increased risk of MI compared to healthy pts in Framingham
RA pts at 1.5x risk of CVD https://t.co/wL4U8Gh5JM
Links:
Dr. John Cush @RheumNow ( View Tweet )
1 week 5 days ago
#RNL2024
ASCVD Risk Calculators underestimate risk in patients of RA
Inflammatory disease was added as a "risk enhancer" in 2019 update
"A low ASCVD and/or absence of symptoms may be not be reassuring" https://t.co/Cz1LRda9xx
Links:
Dr. John Cush @RheumNow ( View Tweet )
1 week 6 days ago
13 Risk Factors for RA-associated Interstitial Lung Disease (ILD)
ILD is the most widespread and fatal pulmonary complication of rheumatoid arthritis (RA). A recent metanalysis shows the pooled prevalence of RA-ILD was approximately 18.7%.
https://t.co/oqb37RWPuZ https://t.co/tp3qBh1wRC
Dr. John Cush @RheumNow ( View Tweet )
1 week 6 days ago
Pearl: Three "S" Rule (Smoking, Seropositivity, Sex/Male): if present the risk of RA-UIP (ILD) goes up nearly 13 fold (ACR23 Abstract 1269) https://t.co/heiTtarS1Y https://t.co/EkHbmMgIEC
Dr. John Cush @RheumNow ( View Tweet )
1 week 6 days ago
RCT 302 Dupuytren contracture pts Rx w/ Surgery (n 101), needle fasciotomy (101), or collagenase injx (100). 292 & 284 completed; Success (>50% improved) @3 mos was same: 71%, 73% & 73%. @ 2 yrs, surgery was superior (78% vs. 50% or 65%) https://t.co/K74p1xpnZx https://t.co/xaC4pdPSFQ
Dr. John Cush @RheumNow ( View Tweet )
1 week 6 days ago
JAMA: Industry Payments to Physicians ($12.13 billion 2013-22)
1 Ortho: $1,360,744,428
2 Neuro: $1,322,668,751
3 Cardio: $1,293,613,594
4 Heme/onc: $825,799,685
5 Int medicine: $588,249,423
6 Endo: $546,513,674
7 FP: $479,105,369
8 Rheum: $464,858,022
https://t.co/GCWchn9IMz https://t.co/6sRwOWm83y
Dr. John Cush @RheumNow ( View Tweet )
1 week 6 days ago
soluble Fms‐like tyrosine kinase‐1 (sFlt-1)/placental growth factor (PlGF) ratio, biomarkers of placental function and adverse pregnancy outcomes. Study of 158 RA pts, 1/2 on TNFi during Preg. TNFi assoc w/ incr birthweight; no effx on sFlt‐1 & PlGF https://t.co/JFvDxrTAfr https://t.co/CRxSEbm2Ru
Dr. John Cush @RheumNow ( View Tweet )
1 week 6 days ago
CDC surveillance data 2019–2021 identified cases:
- 59,655 coccidioidomycosis
- 3,595 histoplasmosis
- 719 blastomycosis (unusually high fatality rate in 2021 of 17%; typically 8%–10%) https://t.co/cDC0nuZLsb https://t.co/Q4QkNtNvJc
Dr. John Cush @RheumNow ( View Tweet )
1 week 6 days ago
FDA Curriculum and Toolkit on Biosimilars for educators; Fact sheets on:
- Biologicals, Biosimilars & InterchangeableProducts
- Generics & Biosimilars
- Manufacturing & Variation
- Biosimilar Regulatory Approval Pathway https://t.co/bHYFPb8VxU https://t.co/bA8I567H8U
Links:
Dr. John Cush @RheumNow ( View Tweet )
2 weeks ago
There is world wide variability the prevalence of #PsA - the global prevalence=112 per 100K adults; and is more common in Europe (207/100K) and North America (64/100K) compared with Asia (37/100K) and South America https://t.co/UY25S00w26 https://t.co/AZMbZ3hG2c
Dr. John Cush @RheumNow ( View Tweet )
2 weeks ago
Systemic Inflammation Index [SII]= PMN# x Plt # / Lymphs# (all from CBC) has predictive value. Review of 16 studies (2893 immune pts & 2346 controls). SII significantly higher in ID vs controls, active vs remission, & those w/ & W/O immune disorders https://t.co/qDDQL88wbv https://t.co/IW1fnaoJRo
Dr. John Cush @RheumNow ( View Tweet )
2 weeks ago