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Articles By Jack Cush, MD

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Early RA and the Chance of DMARD-Free Remission

Early and aggressive treatment of rheumatoid arthritis has become the mantra for most who manage the disease and hope to achieve optimal outcomes - including remission.

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BMI at Age 20 Influences Future Risk of Low Back Pain

A nationwide, cross-sectional study of men aged 30–50 years (n=1385) examined the relationship between weight and back pain over time.

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Fasenmyer Grant to Calabrese and Lederman Will Further the Interface Between Rheumatology and Virology

Two longtime collaborators studying HIV/AIDS at the Cleveland Clinic and Case Western Reserve University have received an $18.5 million grant from the Richard J. Fasenmyer Foundation.

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Rheumatology - the Favored Few

A routine visit, followed by a few post-visit comments from the familly, is all it takes to remind me how great it is to be a rheumatologist.

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Off-Label Use – A Free Speech, Scientific and Safety Issue

Is off-label drug use an example of "free speech"?  Do off-label use guidelines affect every day practice or the way Pharma promotes its product outside of the indications for which it was approved?

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Epidural Steroid Injections Ineffective

A meta-analysis of 30 placebo-controlled trials evaluated epidural corticosteroid injections for radiculopathy, and 8 trials were done for spinal stenosis.

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Colon Cancer Risk Cut by Aspirin and NSAIDs

A population-based study from Northern Denmark studied the effects of aspirin and NSAIDs on colorectal cancer rates (Citation source http://buff.ly/1KJQ6H3).

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Secukinumab Bests Ustekinumab in Psoriasis CLEAR Study

The CLEAR study was a one-year, randomized, double-blind trial compared subcutaneous standard doses of secukinumab (anti-IL17) and ustekinumab (anti-IL12/23) in patients with moderate-severe plaque psoriasis.  

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Amgen Agrees to $71 Million Settlement over Enbrel & Aranesp Promotion

Based on potentiallly off-label promotion of blockbuster drugs Aranesp and Enbrel, Amgen has agreed to a $71 million settlement with 48 states and the District of Columbia.

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Serious Infections are Increasing in Lupus

Tektonidou and coworkers have analyzed hospitalized serious infections (SIE) involving lupus patients over a 15 year period and show that SIE in SLE have increased substantially between 1996 and 2011, and in 2011 are 12 times higher than seen in patients without SLE.

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