Articles By Brian Jaros, MD

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Novel TYK2 inhibitor Zasocitinib

By Brian Jaros, MD

Similar to JAKs, TYK2 is an important mediator of innate and adaptive immune activation. Unlike JAKs, however, TYK2 is thought to play a minimal role in other pathways, such as metabolic and hematopoietic axes. Therefore, it is hypothesized that TYK2-targeted agents could be effective in rheumatic disease, with a potential for less off-target adverse effects. Zasocitinib is a new, oral TYK2 inhibitor generated using artificial intelligence-assisted compound design.

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How New Medications are Reframing Imaging Abnormalities in axSpA

By Brian Jaros, MD

Bimekizumab (BKZ), a monoclonal antibody that selectively targets both IL-17A and IL-17F, was evaluated in the BE MOBILE 1 (non-radiographic axSpA) and BE MOBILE 2 (radiographic axSpA) trials and found to yield significant cli

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Playing it Safe with RA? JAK vs. TNF Debate

By Brian Jaros, MD

Reported safety signals, at odds with the efficacy of these medications, have left rheumatology clinicians in a difficult position when considering when during a patient’s treatment course and in which patients, specifically, JAKi should be used. Two abstracts from ACR convergence 2024 further contribute to our understanding of this potential risk profile.

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  • Brian Jaros, MD

  • Dr. Brian Jaros is an Assistant Professor of Medicine at Northwestern University Feinberg School of Medicine in Chicago, IL, where he recently completed his rheumatology fellowship training in 2024 and was honored as an American College of Rheumatology Distinguished Fellow. Dr. Jaros's clinical interest is in vasculitis and he is the Associate Director of the Vasculitis Center at Northwestern University. He has authored textbook chapters in vasculitis, moderated panels with the Vasculitis Foundation, and serves as Co-PI for several vasculitis research initiatives in his department. Dr Jaros's other focus is on medical education, and he serves as the Associate Program Director of the Rheumatology Fellowship at Northwestern University. 

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