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Quiz Talk (5.22.2026)

Jack Cush, MD

Dr. Jack Cush talks of birthdays, Quizzes and journal articles this week on the podcast.

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BE BOLD Week 16 data - Bimekizumab vs. Risankizumab in PsA

Jack Cush, MD

UCB has released the Week 16 results from BE BOLD trial that will be presented at EULAR 2026 in London on Saturday, June 6.

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A Role for Plasmacytoid Dendritic Cells in Lupus

Jack Cush, MD

Plasmacytoid dendritic cells (pDCs) have been strongly implicated in the pathogenesis of lupus, as their primary product, type I interferon, drive systemic lupus erythematosus and cutaneous lupus erythematosus. A recent comprehensive review synthesizes the available data on pDCs, and, importantly, what we still don't know.

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Early GI Involvement Predictive of Scleroderma Outcomes

Jack Cush, MD

Rheumatology has published a cohort study showing that earlyGI symptoms and overall symptom burden predict both GI progression and mortality in Systemic Sclerosis (SSc).

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pediatric eye uveitis

Immune-Mediated Inflammatory Diseases Following Uveitis

Jack Cush, MD

A Korean insurance claims data study showed children and adolescents diagnosed with uveitis have a 7-fold increased risk of developing an immune-mediated inflammatory disorder (IMID).

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ABA versus HCQ in Palindromic Rheumatism

Jack Cush, MD

Palindromic rheumatism may develop rheumatoid arthritis (RA) and could be an at-risk population. A pilot trial compared abatacept (ABA) versus hydroxychloroquine and demonstrated ABA reduces RA development in a 2 year study. 

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Multicentric reticulohistiocytosis

Update on Multicentric Reticulohistiocytosis

Jack Cush, MD

Have you ever seen multicentric reticulohistiocytosis? Don't worry, it's a rare non-Langerhans cell histiocytosis condition, characterized by papulonodular skin lesions and symmetric erosive polyarthritis, and has only been described in fewer than 500 cases reported worldwide.

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Infectious Rheumatology (5.15.2026)

Jack Cush, MD

Dr. Jack Cush discusses his favorite journal articles from the past week on RheumNow.com.

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Fatigue in SLE

Jack Cush, MD

An NIH lupus cohort study looked at fatigue in SLE and found associations with organ damage, obesity, but does not correlate with disease activity in systemic lupus erythematosus (SLE) patients.

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SI AS SpA ACR

Another IL-17A inhibitor (Vunakizumab) for active Ankylosing Spondylitis

Jack Cush, MD

Vunakizumab, a novel anti–interleukin (IL) 17A monoclonal antibody, was studied in patients with active radiographic axial spondyloarthritis [r-axSpA] and found to be effective and

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Eosinophil

EGPA Review

Jack Cush, MD

A current review of eosinophilic granulomatosis with polyangiitis (EGPA) provides current recommendations on diagnosis and management.

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Fatigue in SLE An NIH lupus cohort study looked at fatigue in SLE and found associations with organ damage, obesity, but does not correlate with disease activity in systemic lupus erythematosus (SLE) patients. https://t.co/63JVDUwu88 https://t.co/3dPOThMbMD

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Dr. John Cush RheumNow ( View Tweet)
Can’t attend #EULAR2026? You won’t miss a thing. RheumNow delivers: 📬 Daily summaries 🎥 Interviews 📊 Key data highlights Follow https://t.co/V10S4oVFsv June 3–6. https://t.co/7Xdj94eFu4

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Dr. John Cush RheumNow ( View Tweet)
Early GI Involvement Predictive of Scleroderma Outcomes Rheumatology has published a cohort study showing that earlyGI symptoms and overall symptom burden predict both GI progression and mortality in Systemic Sclerosis (SSc). https://t.co/ftz6TeZv5Z https://t.co/Nw3wQ06VTq

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Dr. John Cush RheumNow ( View Tweet)
Does Exercise and Lifestyle Modification Improve RA? Do exercise or lifestyle modifications reduce the risk of getting RA or change those with early RA? A current review and meta-analysis found no studies addressing the benefit in pre-clinical RA, but found evidence that https://t.co/Bvp3Ery5Fg
Dr. John Cush RheumNow ( View Tweet)
Goofy study of the month! (pub in JAMA!) RCT 170 adults w/ chronic LBP + MRI disc herniation found that amoxicillin-clavulanate, 500 mg/125 mg bid x 3 mos did not improve pain at 3 or 12 mos (vs PBO). Whatha... https://t.co/njrw6itAP8 https://t.co/CW2ssNPxf1

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Dr. John Cush RheumNow ( View Tweet)
Medical Economics reports only 18% MDs practiced in MD-owned settings, a new low. By Jan '26 hospitals or corporate employment rose to 550,494 & independent MDs fell to 120,900 https://t.co/l0tt3yO9kt https://t.co/pkgmHFPjE1

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Dr. John Cush RheumNow ( View Tweet)
Fatigue in SLE An NIH lupus cohort study looked at fatigue in SLE and found associations with organ damage, obesity, but does not correlate with disease activity in systemic lupus erythematosus (SLE) patients. https://t.co/JEAnhMFJD8 https://t.co/sROKzsyISl

Links:

Dr. John Cush RheumNow ( View Tweet)
Lupus Mortality Risk in Young Women New research using death certificate data from 52,942 females, reveals that systemic lupus erythematosus (lupus) is a leading cause of years of potential life lost among young women in the United States, underscoring the disease’s significant https://t.co/2FSINr6gZN
Dr. John Cush RheumNow ( View Tweet)
NEJM reports a 10 yrs study of Arthroscopic Partial Meniscectomy (APM) for Degenerative Tear — randomized, sham-surgery–controlled RCT of 147 pts w/o Knee https://t.co/WMGRIOunwZ 10 years, found no signif benefit betw APM and Sham surgery (pain, function) & possible worsening https://t.co/979C7IYuyZ

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Dr. John Cush RheumNow ( View Tweet)
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