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A useful urinary biomarker for lupus nephritis Dr. Andrea Fava discusses plenary abstract 1642, presented at #ACR24 https://t.co/5kFXUn3xlF https://t.co/mWTX9SbDGm

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Dr. John Cush RheumNow ( View Tweet)
Hands caring bond

Why should rheumatologists care about aging?

d Patricia Harkins, MD

The global population is aging and none of our rheumatic diseases are immune to the impact of the complexities and so-called “geriatric syndromes”, including sarcopenia, frailty, falls and cognitive impairment, associated with the aging process. Whilst we are increasingly aware of these syndromes, it is sometimes overwhelming to consider just how we may incorporate the unique needs of our older patients into our already busy clinical practice – or perhaps until now we were unsure of their significance and relevance. Why should we care about aging?

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Cyclophosphomide vs Mycophenolate vs Tacrolimus in Lupus Nephritis Dr. Mike Putman discusses abstract 0670, presented at #ACR24. https://t.co/aLzsSSOmML https://t.co/XrEtNZAgHI

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Dr. John Cush RheumNow ( View Tweet)
Beyond the Needle: Redefining the Assessment of Lupus Nephritis Lupus nephritis is one of the most silent and severe manifestations of systemic lupus erythematosus (SLE). https://t.co/JD6z4VTfJn #ACR24 https://t.co/7gEK8acRl0

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Dr. John Cush RheumNow ( View Tweet)
💊Litifilimab- another new molecule for SLE Anti BDCA2 🎯 In cutaneous lupus👉 👉Decrease CLASI score 👉Decrease IFN induced MxA expression #ACR2024 #ACRAmbassador https://t.co/AeJOGhVXIR

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Ritasman Baisya RitasmanB ( View Tweet)
artificial intelligence machine learning computer

ICYMI: Taking AI Out of AutoImmunity: Predicting disease before it develops

d Akhil Sood, MD

the predictive value of a positive ANA test—especially in the absence of other clinical symptoms—remains a challenge. A positive test often leads to further testing, yet it does not necessarily indicate whether a patient truly has an underlying autoimmune disease. The development of AI and machine learning algorithms presents an opportunity to interpret autoantibody tests and predict autoimmune diseases. Here are three studies looking at this issue.

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Cognitive Impairment: The Hidden Burden in Lupus Care Suppose you have a patient with SLE returning for follow-up. Their joint symptoms are well controlled. The kidneys—managed with a combination of biologic DMARD and mycophenolate—show no signs of active urinary sediment or… https://t.co/W8RO5aOaxj https://t.co/EF9P93hdPB
Dr. John Cush RheumNow ( View Tweet)
#ACR24 - Day 3 Report Highlights from Day 3 at ACR24 included the plenary session presentation on Nipocalimab (previously reviewed), but the big highlight was the Lupus Nephritis guideline recommendations. https://t.co/Dif4EUi30b https://t.co/4hfEJ1ef73

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Dr. John Cush RheumNow ( View Tweet)
guidelines.recommendations.jpg

Is Your Practice Up to Date? New Guidelines for SLE Nephritis

d Michael Putman, MD, MSCI

Randomized controlled trials (RCTs) drive guidelines; guidelines drive clinical practice. Because updated guidelines lag trials by many years and dissemination of guidelines takes additional time, rheumatologists often practice “behind the data.” The 2024 ACR Guidelines for the Management of SLE Nephritis reaffirmed many of our typical practice patterns, including hydroxychloroquine for all, renin/angiotensin blockade, and favoring mycophenolate mofetil over cyclophosphamide.

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GLP-1 Agonists Show Promise in Slowing Kidney Disease in Lupus Nephritis Glucagon-like peptide-1 receptor agonists (GLP-1Ra) have transformed the treatment landscape for type 2 diabetes and obesity. #ACR24 https://t.co/6QqEH8X2VJ https://t.co/Ch2i9zZYii

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Dr. John Cush RheumNow ( View Tweet)
Sleep asleep

Dreaming of Relief: The Importance of Sleep in Lupus and Rheumatoid Arthritis

d Andrea Fava, MD

Sleep plays a critical role in regulating inflammation and overall health. In rheumatic diseases like lupus and rheumatoid arthritis (RA), disrupted sleep is common and can exacerbate symptoms and disease progression. Experts Dr. Al Kim, Patty Katz, and Dr. Yvonne Lee emphasized the importance of addressing sleep disturbances in these conditions.

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Beyond the Needle: Redefining the Assessment of Lupus Nephritis Lupus nephritis is one of the most silent and severe manifestations of systemic lupus erythematosus (SLE). https://t.co/fvGG0BZbOL #ACR24 https://t.co/wPXQz9Vese

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Dr. John Cush RheumNow ( View Tweet)
Abstract 2681: #SDOH factors & SLE risk: - Low income (AOR=2.779). - By race/ethnicity NHB (AOR=2.429), Hispanic (AOR=1.616). Behavioral: Psych distress (AOR=2.127), no exercise (AOR=1.677). Access: Medicaid (AOR=2.540), transport barriers (AOR=20.394). @RheumNow #ACR24

Akhil Sood MD AkhilSoodMD ( View Tweet)

#Ianalumab 300 mg sc q monthly B cell depleted and changes BAFF signalling 👇⬇️IFN May be promising in #lupus #SLE +data in primary #Sjogrens ACR24 @RheumNow @ACRheum Abst#2425 Needs Phase3 ➡️I suspect safer than CAR T and Bispecific T cell engagers but ? ⬇️efficacy

Janet Pope Janetbirdope ( View Tweet)

Prior studies have shown that IFN is increased in non-lesional skin of SLE pts. In this study, they found a ⬆️ expression of IFN stimulated genes (ISGs) in pts w/ a history of CLE. No correlation w/ CLASI act & IFN scores but only few pts. @RheumNow #ACR24 abs2678 https://t.co/cPT6yPkoCb

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sheila RHEUMarampa ( View Tweet)
Prof Petri reports the ff predictors of fracture in SLE: -older age -Caucasian race -female sex ⚠️ Prednisone (but not recent IM triamcinolone or IV methylpred) is a MAJOR risk factor. When possible, avoid prednisone! @RheumNow #ACR24 #ACRbest abs2679 @rheumarhyme https://t.co/q2NMRaYsAF

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sheila RHEUMarampa ( View Tweet)
All-caps abstract text throw-down by Michelle Petri re:fractures in SLE 😆 I keep saying this; our obsesssion with vitamin d is not commensurate w/reality It's. The. Prednisone. #ACR24 @RheumNow Abstr#2679 #ACRBest https://t.co/13luByNvYT

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Mike Putman EBRheum ( View Tweet)
What are the predictors of fracture in #SLE? 🦴Prednisone! Even at low doses ≤5mg 🦴Stroke 🦴Caucasian race 🦴Female 🦴Low BMD Try to avoid steroid use. If they are needed, IM triamcinolone or IVMP preferable to oral GC. Ab2679 #ACR24 @RheumNow

Mrinalini Dey DrMiniDey ( View Tweet)

Data from the RISE registry show that 9.3% of SLE pts had thrombocytopenia and a smaller percentage with mod-severe TP (2.7%). Severe TP was much rare. Large data, but well represented grp? @RheumNow #ACR24 abs2680 https://t.co/Y1Lo9lJGtO

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sheila RHEUMarampa ( View Tweet)
Late breaking abstract L17 CAR-NK Therapy for Refractory SLE. In a trial of 20 severe SLE patients: - 75% achieved LLDAS, 50% achieved DORIS remission at 6 months - B cell reconstitution: 2–3 months post-treatment - Safety: 2 mild cytokine release syndrome with fever; no severe… https://t.co/MS8cutm48o

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Antoni Chan MD (Prof) synovialjoints ( View Tweet)

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