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Lasker,award,science,biomedical

2022 Lasker Award Winners

EurekAlert!

The Lasker Foundation has announced the winners of its 2022 Lasker Awards, widely regarded as America’s top biomedical research prize since its creation more than 75 years ago. Here's a look at the award winners and their important contributions to biomedical research.

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Heavy Metal Rheumatology (9.23.2022)

Jack Cush, MD

Below are this week’s highlights from RheumNow, as discussed by Dr. Jack Cush. Thanks to all of you for your kind comments and great reviews of our weekly podcast. Please let us know how we can improve by emailing me or recording your suggestion using the "Ask Cush Anything" link on our website.

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COVID infection mask

COVID Outcomes in Dermatomyositis

Jack Cush, MD

A retrospective study of dermatomyositis (DM) patients with COVID-19, shows that DM patients without comorbidities fair well (with regard to mortality and hospitalisation).

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Does Fibromyalgia Need B12? (9.9.2022)

Jack Cush, MD

Can we predict the bad outcomes? Like when ITP evolves into SLE; or when psoriasis will develop arthritis; or if Sjogren's will develop lymphoma? Let's dive in and review these journal reports and this past week's news from RheumNow.com.

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Goofy But True

Jack Cush, MD

Dr. Jack Cush discusses declining survival rates in the USA, FDA approvals of new COVID subvariant boosters and other odd and possibly true new research reports from the past week on RheumNow.com.

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virus,injection,COVID,vaccine

FDA Approves BA.4 and BA.5 Omicron COVID Booster Vaccines

Jack Cush, MD

Today the FDA authorized the updated Omicron subvariant (BA.4 and BA.5) COVID-19 booster shots manufactured by Pfizer and Moderna; with an anticipated ship/start date of early September 2022. The BA.5 subvariant accounts for more than 88% of U.S. infections.

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flu

Influenza Vaccination Recommendations

CDC

The CDC has published an update to the recommendations from the Advisory Committee on Immunization Practices (ACIP) on the use of seasonal influenza vaccines in the United States for the 2022-23 season.

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"Double blind" an interesting read (Ann Int Med) of early COVID w/ no known effective therapy, doctor trepidation & and the bravery/will of sick ICU COVID pts as they consent to to enroll in the blinded ACTT trial w/ remdesivir https://t.co/N2bZq0JDmn https://t.co/iPLnNtQoER

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Dr. John Cush RheumNow ( View Tweet)
Metanalysis of 25 studies examined effects of NSAID therapy on COVID-19 outcomes and confirms NSAIDs do not increase the likelihood of SARS-CoV-2 infection and do not worsen outcomes in patients with COVID-19. https://t.co/FAJ58stmv1

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Dr. John Cush RheumNow ( View Tweet)

Are we set for the next "Twindemic"? - Continuation and evolution of COVID BA.5 to? - Flourishing Influenza in a population who has vaccine burnout? Some predicting severe flu based on Australia’s 2022 flu season, climate change, more https://t.co/qWuhWjaAFa

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Dr. John Cush RheumNow ( View Tweet)

New CDC data on vaccination/boosters during BA.5 wave for deaths, age 50+ https://t.co/HGyjNwUveD Compared w/unvaccinated: —92% reduction of death for 4 shots —No difference in reduction between 3 and 2 shots (~82%) [that's a 12-fold ⬇️risk of death for 4 shots in July 2022] https://t.co/3JDjCLbEyh

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Eric Topol EricTopol ( View Tweet)
New download available! COVID Deaths at 3 Mos vs. 30 Mos https://t.co/SLGJGh5NX1 https://t.co/QhWdvNHntk

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Dr. John Cush RheumNow ( View Tweet)
Provacative read from @VPrasadMDMPH on why we no longer need to or should wear masks in our clinics and hospitals (Yes, with COVID+ pts --- No, everywhere else). My advice: wear masks in high risk environments/situations. https://t.co/cECeieQ2YL https://t.co/PbX8xnfgqM

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Dr. John Cush RheumNow ( View Tweet)
The Atlantic has published an insightful article on "Brain Fog", especially as a Long Covid consequence (IMHO: Brain fogs primary cause is poor sleep, fibromyalgia, chronic fatigue - but can be complication to primary CNS events) https://t.co/SlwzRDSVSf https://t.co/qrBvV5oyUA

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Dr. John Cush RheumNow ( View Tweet)
In your RHEUMATOLOGY practice how often are you seeing #LongCovid (new fatigue,brainfog,breathless etc) in your immune dis pts with COVID ( i.e. > 1 month) @CCalabreseDO @jeffsparks @zach_wallace_md @philipcrobinson @JYazdanyMD @alhkim @RheumNow @EBRheum @rheum_cat @AWIRGROUP

Leonard Calabrese LCalabreseDO ( View Tweet)

COVID Outcomes in Dermatomyositis A retrospective study of dermatomyositis (DM) patients with COVID-19, shows that DM patients without comorbidities fair well (with regard to mortality and hospitalisation). https://t.co/nlCVHt3XeS https://t.co/Bhc47k7rMD

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Dr. John Cush RheumNow ( View Tweet)
Head Scratcher? Study of UK Biobank cohort (n=380,380) shows those taking Rx Folate had increased risk of COVID-19 Dx (OR 1.51; 1.42–1.61) and Death (OR 2.64; 2.15–3.24). MTX use (+/- folate) had no increase in COVID or COVID death(1.07;0.57–1.98) https://t.co/MLE1sL7KG2 https://t.co/adoLO9qLON

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Dr. John Cush RheumNow ( View Tweet)
FDA Approves BA.4 and BA.5 Omicron COVID Booster Vaccines Today the FDA authorized the updated Omicron subvariant (BA.4 and BA.5) COVID-19 booster shots manufactured by Pfizer and Moderna; with an anticipated ship/start date of early September 2022. https://t.co/VzQBFgvAqu https://t.co/r0pQuoDVcn

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Dr. John Cush RheumNow ( View Tweet)
This precipitous drop and current level is substantially worse than 21 peer countries https://t.co/NAEMjhs4j3 https://t.co/QhrZ1Xnwcr

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Eric Topol EricTopol ( View Tweet)
Mass Gen Brigham study of Rheum (SARD) pts COVID severity over time (3/20-1/22) shows less severe COVID over time. 1449 SARD pts had COVID-19 (1/3 RA); 28% severe. Early COVID was more severe (46%) vs 15% w/ Omicron. Unvax were more severe (78% v 60%) https://t.co/DTge2od82Q https://t.co/LXeujT6zd5

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Dr. John Cush RheumNow ( View Tweet)
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