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What would you do? A middle aged woman has pain and impaired hand function with her PIP&DIP erosive hand #osteoarthritis? Exam - jts are tender w soft tissue swelling? #NSAIDs, #denosumab, #methotrexate? 🤷‍♀️ A +RCT of #MTX in #erosive #hand #OA at #EULAR2023 @RheumNow @eular_org https://t.co/7rp3nReTPd

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Janet Pope Janetbirdope ( View Tweet)

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EULAR 2023 – Day 1 Report

d Jack Cush, MD

EULAR 2023 launched today to crowds of attendees.  The opening Plenary session and presidential address by Dr.

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Are we going to treat hands OA with MTX? Moderate effect on VAS pain at 6 and 12 months in a small RCT vs. PBO in hands OA WITH MRI detected synovitis. Thoughts 1) Is it really OA? 2) Benefit Risk balance remains debatable @RheumNow OP0070 #EULAR23 https://t.co/WLlX48NtGT
Aurelie Najm AurelieRheumo ( View Tweet)
Randomized double blind, placebo controlled MTX trial in inflammatory #handOA - pts with MrI detected synovitis. 97 pts 20mg MTX helped reduce pain and stiffness at 6 months. @rheumnow #EULAR2023 abst#OP0070 Early work with some promise!

Bella Mehta bella_mehta ( View Tweet)

Interesting newer potential theraputics in #handOA discussed at #EULAR2023 - denosumab had clear structure modifying effects in erosive habd OA compared to placebo. Monocentric, placebo controlled, doubke blind phase 2 study of 100 pts. @rheumnow abst#OP0071

Bella Mehta bella_mehta ( View Tweet)

Colchicine 0.5mg BID for 12 weeks in #HandOA did not relieve pain. Results from 186 pts- double blind placebo controlled, randomized. MCID on VAS of 15 was not achieved. Presented at #EULAR2023 today abst#op0073 @RheumNow

Bella Mehta bella_mehta ( View Tweet)

brain,pain,perception,cns

Orbitofrontal Cortex Implants to Assess Chronic Pain

d Jack Cush, MD

Nature Neuroscience reports a novel approach to assessing chronic neuropathic pain - intracranial electrodes in the anterior cingulate cortex and orbitofrontal cortex (OFC) to map chronic pain signaling. 

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3-4-5 Rule (5.26.2023)

d Jack Cush, MD

Dr. Jack Cush reviews more than a dozen news, journal articles and RNL highlights from this past week on RheumNow.com.

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Falls with Knee Osteoarthritis

d Jack Cush, MD

A study of adults aged 45-85 yrs shows that knee osteoarthritis (OA) is an independent risk factor for falls, suggesting a greater need for awareness and prevention.

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NSAID Prescribing Decreasing

d Jack Cush, MD

Multinational metanalyses of data between 1989 and 2022 shows that NSAID prescriptions have decreased over time, and differs according to geographical locations.

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Microbiome of Hip and Knee Osteoarthritis is not "Sterile"

d EurekAlert!

Next-generation DNA sequencing (NGS) techniques show the presence of bacterial DNA in surgical specimens of hip and knee arthritis, from patients undergoing first-time total joint arthroplasty, reports a study in The Journal of Bone & Joint Surgery. 

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Conaghan shares unpublished data from PROMOTE study at #RNL2023 Early data shows MTX benefits pain in patients w/ OA, particularly more metabolically active. Looking forward to more data on this-- https://t.co/Zfh7CbqvPi https://t.co/kIYKRFtUX2

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Dr. John Cush RheumNow ( View Tweet)
FDA approves a NGF inhbitor bedinvetmab (Librela) to treat osteoarthritis in Dogs!. Recently FDA approved NGF inhibitor cats w/ OA --- Yet 4 different NGF inhibitors failed in their development for human OA - are cats & dogs treated better than us? https://t.co/Tbca0PiEL2 https://t.co/Y7mViSa5J4

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Dr. John Cush RheumNow ( View Tweet)
Does King Charles have Sausage Digits (dactylitis) or OA? https://t.co/Wg3JaTAGf1 https://t.co/Wg3JaTAGf1 https://t.co/iAHfYbZD7t

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Dr. John Cush RheumNow ( View Tweet)
Watch: Insights into the Future of Osteoarthritis RheumNow Live 2023: Philip Conaghan, MBBS, PhD, University of Leeds, Biomedical Research Centre https://t.co/xjccnULOBn https://t.co/inIDFDN7GA

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Dr. John Cush RheumNow ( View Tweet)
Does King Charles have Sausage Digits (dactylitis) or OA? https://t.co/mRis21OWKH https://t.co/mRis21OWKH https://t.co/TmPDKu6ARh

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Dr. John Cush RheumNow ( View Tweet)
NY Times on Arthritis Prevention A reader question ("Ask Well") to the New York times wonders "is arthritis avoidable"? A recent survey suggests that up to 60% of adults have been told by an HCP they had some form of arthritis. https://t.co/ORcbQHjgSk https://t.co/mw5YGYdgWx

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Dr. John Cush RheumNow ( View Tweet)
Brigham review (2018-2022) of 47 CPPD pts: M=F, mean age 72 yrs 68% w/ acute CPP arthritis 40% w/ CPP inflammatory arthritis 62% w/ OA with CPPD. Compared to Gout, CPPD Significant unmet Rx need & lower RAPID3 (8.1 vs 12.1) https://t.co/cLNjGxi6qF https://t.co/76PoepxRjR

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Dr. John Cush RheumNow ( View Tweet)
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NY Times on Arthritis Prevention

d Jack Cush, MD

A reader question ("Ask Well") to the New York times wonders "is arthritis avoidable"?



A recent survey suggests that up to 60% of adults have been told by an HCP they had some form of arthritis.

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Brigham review (2018-2022) of 47 CPPD pts: M=F, mean age 72 yrs 68% w/ acute CPP arthritis 40% w/ CPP inflammatory arthritis 62% w/ OA with CPPD. Compared to Gout, CPPD Significant unmet Rx need & lower RAPID3 (8.1 vs 12.1) https://t.co/nFOW4FS0fp https://t.co/3n6WTg66r8

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Dr. John Cush RheumNow ( View Tweet)

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