Participation is Up! (1.31.2025)

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. We also have two call-in cases on "Ask Cush Anything".

Be sure to join in the fun at RNL 2025 next weekend - Gong Show Karaoke; what will you sing?

  1. Korean Study of 10,013 #SLE pts (91%F) those on immunosuppressives were not at greater risk for cancer. Total CA risk (n 368) was 59 per 10,000 PYs. Most common Thyroid, breast, Gastric, colon & cervical. https://buff.ly/40WDSMR
  2. Review of 39 imaging studies (12 MRI, 26 evaluated ultrasound) in pts w/ clinically suspect arthralgia showed variable results for imaging predicting progression from CSA to inflamm. arthritis (RA). US sensitivity/specificity = 37%/90%; MRI was 45%/84% https://t.co/uUl5i2t7ib
  3. NIH study of MSK disease burden finds research on neck pain as most underfunded (0.83%) followed by LBP (13.9%), OA (35.1%) & RA (66.3%) - NIAMS is low compared to other institutes. In USA, MSK dz affect 1 in 3 people, approximately 127.4 million individuals.… https://t.co/MqU9TsY6GR
  4. NHANES survey data on 2200 #RA pts shows dietary modification can yield reduced all-cause mortality risk. Diets w/ high Healthy Eating Index & low Dietary Inflammatory Index (DII) reduced mortality (HR 0.70; 95% CI: 0.53–0.92; adjusted P = 0.01) https://t.co/T77YQMvRQ2
  5. German database shows since 2010, work participation has improved for rheum pts, reflected in higher employment, reduced absenteeism and less disability retirement. However, patients have not reached population employment rates. https://t.co/B8VKBgGNGe
  6. SubAnalysis of STOP Gout Trial: 277 pts w/ CKD received either allopurinol or febuxostat. Most achieved SUA goal (79% vs 81%), fewer allopurinol pts had gout flares (32% vs 45%; P=0.02); AKI only seen stage w/ 3 CKD (allopurinol > febuxostat) https://t.co/wwfVCei4Ej
  7. Open label trial of starting MTX in 11 uncontrolled gout pts previously Rx w/ IV pegloticase (PEG 2-27x) showed if gout pts failed PEG monotherapy, only 1/11 (9%) showed a good response to adding MTX w/ PEG. MTX must be started w/ PEG initiation to work https://t.co/aoBtyIRbQe
  8. Febuxostat (ULORIC) is discontinued by the manufacturer in the USA. This week an FDA update on drug shortages list announced Uloric has been discontinued. Takeda sited dropping sales, generic competition, and CV safety concerns in the last decade. GENERIC febuxostat should still… https://t.co/QcUNCUFfvJ
  9. Infectious Sacroiliitis        
  10. Adalimumab Withdrawal in Uveitis Patients     
  11. Young Males and Future Risk of MSK and Chronic Diseases 
  12. Ask Cush Anything
    • Mayrah Mansoor, MD – MTX toxicity and vitamin A and dextromethorphan dosing
    • Ken Wasser, MD – Low dose radiation for osteoarthritis
  13. Register for RheumNow Live 2025 and see Rheums at Gong Show Karaoke  --> click here

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