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Depression and RA Dr. Jack Cush reviews the news, journal reports and regulatory approvals from the past week. https://t.co/nJZD4D2ByC https://t.co/ET3Xp9cK62

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Dr. John Cush RheumNow ( View Tweet)
Have a Rheumatology question or case for Jack Cush? Record it here and we'll feature it on an upcoming podcast. Tell us your name and where you practice rheumatology. https://t.co/a3XeAa2lcG https://t.co/dTZa2uQF97

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Dr. John Cush RheumNow ( View Tweet)
PSA068.jpg

Many with Psoriatic Arthritis Fail to Achieve Minimal Disease Activity

d Jack Cush, MD

Despite the availability of numerous advanced therapies for psoriatic arthritis (PsA), there remains a substantial burden and unmet need for improved therapies, according to a newly published Canadian study.

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Curbside Consults (2.16.2024)

d Jack Cush, MD

Dr. Jack Cush answers audience clinical case questions sent by email or "ask Cush anything". Cases and questions from:

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DMARDs, MTX & TNFi can lower CV risk in RA pts. #RWCS24 https://t.co/Un457RYL8R
Dr. John Cush RheumNow ( View Tweet)
Combo IL-23 and TNFi synergistic benefit in UC in the proof-of-concept VEGA trial. More data to come! #RWCS24 @RWCSmtg @RheumNow https://t.co/FgLTR2PBYJ

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Dr. Rachel Tate uptoTate ( View Tweet)
Dr. J. Giles reviews adipose tissue as a source of inflammatory cytokines like TNF, IL-6, IL-1, IL17, etc. #RWCS24 @RWCSmtg @RheumNow https://t.co/AYD9PpwNE6

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Dr. Rachel Tate uptoTate ( View Tweet)
#RWCS24 @JointMD @RWCSmtg review the TNFi differences molecularly. @RheumNow https://t.co/6JAnNwwV0n

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Dr. Rachel Tate uptoTate ( View Tweet)
April Armstrong RNL

Co-management of Psoriatic Disease

d Richard Conway, MBBChBAO, PhD

It is a common clinical scenario to see someone with both severe psoriatic arthritis and skin psoriasis. In an ideal world this would involve a combined clinic with our local friendly dermatologist. For many of us, however, this is not practical for many reasons. The excellent Saturday morning session on choosing systemic therapies in psoriatic disease at RheumNow Live 2024 from dermatologist extraordinaire Dr. April Armstrong was therefore hugely insightful.

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VITAL Info on Autoimmune Disease (2.9.2024)

d Jack Cush, MD

Dr. Jack Cush reviews the journal reports from the past week on RheumNow.com. Highlights are summarized by three songs: "Stairway to Heaven", "You're No Good", and "How Long (has this been going on)".

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Pre-Treatment Testing with Biologics Falls Short

d Jack Cush, MD

US commercial insurance claim analysis of laboratory screening and monitoring practices in chronic inflammatory skin disease (CISD) patients shows that < 60% received the recommended pretreatment testing when starting systemic immunomodulatory treatment.

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AS v nr-AxSpA for TNFi - no diff in response @JointMD @RheumNow #RNL2024 ADA: ASAS20 AS 58%, nr-AxSpA 52%, ASAS40 AS 39%, nr 36% (ATLAS, ABILITY-1) ETN: ASAS 20 59%/52%, ASAS50/40 44%/33% in p3 AS study v EMBARK CZP: RAPID-AxSpA - no diff bw AS & nr-AxSpA response in same trial https://t.co/Rau2CDYbY4

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Eric Dein ericdeinmd ( View Tweet)
Rheumatology drugs in pregnancy. Just missing leflunomide in that big no no section @DrCassySims @RheumNow #RNL2024 https://t.co/ZPtTGRqPki

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Richard Conway RichardPAConway ( View Tweet)
@reumacia @RheumNow You are absolutely right. The point was not generally used for psoriasis ( not PsA). I was surprised my self šŸ¤•. Here is the slide again by Dr. Armstrong , great talk by the way. Let me know if you want the handout. https://t.co/C11Gkn2jho

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Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
JAK safety and malignancy risk. Great talk by kevin Winthrop. #RNL2024 @RheumNow https://t.co/d7WRHJxrpM

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Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Dr. Winthrop avoid JAKi and TNFi in pts with chronic lung infections like MAI. #RNL2024 @rheumnow https://t.co/TfMa7hktL9

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TheDaoIndex KDAO2011 ( View Tweet)
#RNL2024 @RheumNow @_AprilArmstrong Choosing a biologic in Psoriasis TNF - great in PsA, pregnancy. Avoid in demyelinating, hep B IL-17 - robust skin, PsA (axial too). Avoid in IBD IL-23 - robust skin, PsA evidence, fewer injections https://t.co/9Xt7Nx1tKq

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Eric Dein ericdeinmd ( View Tweet)
antibody (Keep)

Anti-Drug Antibodies and Biologic Drug Responses

d Jack Cush, MD

A prospective cohort study suggests the presence of antidrug antibodies may be associated with bDMARDs nonresponse in rheumatoid arthritis (RA). Should we be monitoring ADAbs (especially in nonresponders)?

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Data from the American Rheumatology Network (2014ā€“2021) shows that among 15182 new TNFi initiations, only 45% had a dz activity measure (CDAI/RAPID3); and of these, only 47% had a TJC, SJC or pain score. Can you treat HTN without measuring BP? https://t.co/SsnF7Taky1 https://t.co/LN72IAWs8n

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Dr. John Cush RheumNow ( View Tweet)
Retrospective study of 170 #RA on TNFi (Inflx 53%, ADA 28%, CZP 19%). RF, CCP, Drug levels, anti-Drug Abs done.@6 mos HI baseline RF linked to lower drug levels for IFX & ADA; but not CZP. IFX/ADA Hi-RF pts had more dropouts vs CZP (80%/75%/33%, p=0.002) https://t.co/AIgJNkzcWu https://t.co/pQmfmLoFwe

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Dr. John Cush RheumNow ( View Tweet)

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