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ACR 2024 - Day 2 Report

Jack Cush, MD

Plenary sessions began the day, followed by thousands on the abstract floor. Here are a few of my favorite presentations from day 2 at ACR 2024.

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Mental health, sex, and comorbidities are key factors in determining recalcitrant psoriatic arthritis (PsA). Key findings: - 21.7% of patients required ≥4 biologic/targeted synthetic DMARDs. - Female patients and those with depression were more likely to be recalcitrant. - No… https://t.co/I9YYoRnLwh https://t.co/VtnPceVLOZ

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Antoni Chan MD (Prof) synovialjoints ( View Tweet)
In earlier studies of Vit D, there were conflicting evidence as to whether it reduced or increased the risk of RA and #SLE @RheumNow #ACR24 @rheumarhyme https://t.co/PvjjmhHaOd

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sheila RHEUMarampa ( View Tweet)

Phase 2 DAHLIA study in Sjogrens Anti-neonatal Fc receptor an “nipocalimab” w/remarkably encouraging results clinESSDAI significantly better at wk24, notably met QOL domains as well Finally getting good news in SjS! #ACR24 @RheumNow #ACRbest Abst#2527 https://t.co/e3uQmqJZ1o

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Mike Putman EBRheum ( View Tweet)
📢 Late breaking #2002 ➡️In ICI-induced arthritis, patients (n=100) report worsened pain, fatigue, & physical function vs population norms. ➡️High disease activity worsens symptoms #acr24 @RheumNow @jhrheumatology

Caoilfhionn Connolly CaoilfhionnMD ( View Tweet)

📢Late-breaking #2003 🔑 Cappelli et al @jhrheumatology finds hip OA is NOT a significant risk factor for #ICI-IA 🔴#ICI-IA linked to lower mortality #ACR24 #ACRBest @RheumNow

Caoilfhionn Connolly CaoilfhionnMD ( View Tweet)

Fertility in RA. Improved outcomes in the T2T group. Abstr#1647 @RheumNow #ACR24 https://t.co/gLpY8enaEb

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Antoni Chan MD (Prof) synovialjoints ( View Tweet)
Shifting Trends in Initial RA Treatment Approaches A recent study by Sparks et al (Abstract #0509) reveals evolving trends in disease-modifying antirheumatic drug (DMARD) usage for rheumatoid arthritis (RA) over two decades in the U.S. https://t.co/6FN0WayZZR #ACR24 https://t.co/dc3CiNpKmx

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Dr. John Cush RheumNow ( View Tweet)
Abst#2413 SLE Cohort of > 2900 pts over 50 yrs - Prevalence of proteinuria at the time of SLE dx has not changed over the decades. Prevalence of proteinuria also did not change at 5 and 10 yrs after dx. Earlier use of HCQ has not led to a ⬇️in lupus nephritis. @RheumNow #ACRbest

TheDaoIndex KDAO2011 ( View Tweet)

A study exploring the benefits of treating RA patients to remission after achieving low disease activity (LDA). Key findings: - Among patients initially at LDA, achieving remission (CDAI ≤2.8) led to significantly better functional outcomes and reduced durable medical equipment… https://t.co/SNPKlRieur https://t.co/YIQNMf3Oap

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Antoni Chan MD (Prof) synovialjoints ( View Tweet)

Abst#1493 complete renal response (< 0.5 g/g w/< 10 mg/day pred); renal remission (UPCR < 0.3 g/g w/< 5 mg/day pred). 60 LN pts followed 3 yrs: 40% CRR & 19% RR. Pts not in CRR/RR had⬇️eGFR w/more decline in eGFR over time. No difference b/t CRR/ RR @rheumnow #ACRbest #ACR24

TheDaoIndex KDAO2011 ( View Tweet)

What is #healthliteracy? Why is it important for our patients with #RMDs? Come to poster 1913 today at #ACR24 to find out about health literacy & outcomes in #InflammatoryArthritis For more information on this important topic, read my article @RheumNow https://t.co/llWs5aYtpK

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Mrinalini Dey DrMiniDey ( View Tweet)

"There's an app for that" but is it enough? US informatics national survey 2017-18: Rheum pts with digital health tools weren't any healthier living than those without (maybe helps exercise) It might be a conversation starter, but it's only an adjunct #ACR24 ABST1929 @RheumNow https://t.co/EZpSwm0zuP

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David Liew drdavidliew ( View Tweet)
Probably no surprise, but if you can navigate the digital world, it portends work for your rheum disease. all @MedUni_Wien rheum clinic pts did an eHealth survey high eHealth literacy did much better We can't leave digital stragglers behind! #ACR24 ABST1942 @Stiddyo @RheumNow https://t.co/c9IyPz6ujJ

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David Liew drdavidliew ( View Tweet)
Effective RA therapy is about more than just joints 🇪🇸 RA cohort TNFi for first 24w led to: Lean mass index i.e. muscle going up Fat mass index i.e. fat trending down Muscle & fat composition are important Systemic Rx can deliver systemic benefits #ACR24 ABST1348 @RheumNow https://t.co/mZjcHwxMgW

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David Liew drdavidliew ( View Tweet)
Dentition is important in RA, but it's easy to forget it's a matter of life or death. NHANES data shows fewer teeth strongly correlates with higher mortality (esp cardiovascular). Missing teeth = CV death HR >30 Holistic dentition is holistic RA care #ACR24 ABST1325 @RheumNow https://t.co/Z40bSFybuS

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David Liew drdavidliew ( View Tweet)
Active early RA accentuates regional MSK pain. Non-articular pain: easy to ignore & focus on active RA yes, some is related to RA dx activity BUT actually it becomes a bigger issue over time Worth identifying to: clarify what isn't RA Rx appropriately #ACR24 ABST1335 @RheumNow https://t.co/iN5rsyr7Bx

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David Liew drdavidliew ( View Tweet)
I've shared some further thoughts on @jeffsparks SAIL-RA study and its finding of the strong association of RA-ILD with disease activity in early RA. And of course couldn't resist going on a tangent about the ACR ILD guidelines! #ACR24 @RheumNow https://t.co/UUDbWw38Im

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Richard Conway RichardPAConway ( View Tweet)

A key practice changing study (I hope) from #ACR24 has been the preCARA study. Fertility increases with aggressive disease control. My video on this study is up now on @RheumNow https://t.co/Pf3rdTHbOJ

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Richard Conway RichardPAConway ( View Tweet)

VERY exciting SLE update from Fava et al. Machine learning used to generate urinary protein panel predictive of intra-renal inflammation BETTER than serum biomarkers C3, C4, dsDNA Also monitoring tool for renal response. Outstanding. @RheumNow #ACRbest #ACR24 https://t.co/YXgKrSU4UQ

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Brian Jaros, MD Dr_Brian_MD ( View Tweet)
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