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Secondary Sjogren’s Ups Rheumatoid Arthritis Severity

A Swiss observational study has shown that rheumatoid arthritis (RA) patients with concomitant Sjögren’s disease (SjD) are more likely to have a severe RA phenotype, and be less responsive to treatment.

From a total of 5974 RA patients, there were 337 patients with concomitant SjD. All patients were treated with either TNF inhibitors, non-TNFi or JAK inhibitors.

Sjogrens RA patients were were more likely to be female, seropositive with higher disease activity scores, and radiographic erosions. After one year of advanced treatment, those with secondary SjD were less likely to reach DAS28 remission and more likely to stop TNFi treatment (adj HR 1.3 [95% CI 1.07–1.6], non-TNFi (adj HR 1.12 [0.91–1.37] and JAKi HR 0.97 [0.62–1.53]). 

RA patients with secondary Sjogrens had more severe RA, were less responsive to treatment, and more likely to fail TNFi.


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The author has no conflicts of interest to disclose related to this subject