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OP0140 at #EULAR2021:
➡️Obs, prospect Nordic study characterized axSpA pts w/ high BASDAI + ASDAS & multiple bDMARD use (indicating difficult to tx dz)
➡️1 in 10 received at least 3 bDMARDs
*⃣Multiple switchers were more often F, had higher b/l dz activity, & psoriasis
@Rheumnow https://t.co/syq0szVWKe
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Baseline Vitamin D 😎☀️correlated with biologic response in RA pts.
⭐️EULAR good response: 19.6% Vit D >20 vs 4.2%⬇️Vit D
⭐️Remission: 14.4% ⬆️Vit D vs 3.2% ⬇️Vit D
Abs#POS0100
#EULAR2021 @RheumNow
Robert B Chao, MD doctorRBC ( View Tweet)
No clear winner here. The majority would use #IL23 inhibitors as either 2nd or 3rd line bDMARDs and for #psoriaticarthritis with severe #psoriasis. Thank you for participating in the polls #EULAR2021 @RheumNow https://t.co/b8wzaRVTqw
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Rituximab in PMR. Intriguing
proof of concept (SB?) RCT
(1:1, total n=47 (recent dx 38/relapsing 9))
17w rapid PNL taper
ritux 1g x1
21w:
steroid-free remission: 48% v 21%
PNL ≤5mg/d: 100% v 54%
effect mainly from recent dx pts
We do need options!
POS0343 #EULAR2021 @RheumNow https://t.co/g6xJekY92O
David Liew drdavidliew ( View Tweet)
HUR-BIO real life data, PsA pts started bDMARDs w/in 18 mo of dx vs almost 3x later in RA pts (tended to remain on csDMARDs.) This distinction may be explained by synthetic DMARDs on activity differences between the RA & PsA. Abstract #POS0633 #EULAR2021 https://t.co/VkkF28jm2f https://t.co/IkfGdZYNY3
Links:
Dr. Rachel Tate uptoTate ( View Tweet)
Poster #POS0633 detailed HUR-BIO PsA pts started bDMARDs w/in 18 months of dx vs, on ave, 3x longer to start bDMARDs in RA pts in real life data. What do you drugs do you start in your PsA pts after dx? Feel free to detail me below! #EULAR2021 @RheumNow
Dr. Rachel Tate uptoTate ( View Tweet)
Dr Marsman presents positive RCT of Rituximab in PMR. GC-free remission 48% vs 21% (p=0.049) GC<=5mg 100% vs 47% (p=0.005) @RheumNow #EULAR2021 Abstr#POS0343 https://t.co/tjkKTS6DMN
Richard Conway RichardPAConway ( View Tweet)
#POS0022 prosp study of CTZ pregnancies: 1392 preg w/1425 outcomes @UCBUSA database
88.4% live births, 10.5% preg loss, 0.8% still birth
2.4% congen malform (w/2.1% major)
Preg loss⬅️Crohn's, NSAIDS, MTX
Preterm labor⬅️GCs, maternal infx
⬇️birth wt⬅️RA & GCs @rheumnow #EULAR2021 https://t.co/qnNcDIz8Ge
k dao KDAO2011 ( View Tweet)
Real-world data from PsABio: 🚺generally start biologics in a worse PsA state than🚹. Although treatment improvements were similar between sexes, 🚺remained in worse health at 1 yr, and stopped/switched bDMARD earlier. Abstract #OP0232 #EULAR2021 @RheumNow https://t.co/oIGu0HzisQ https://t.co/uLnYOq8ypx
Links:
Dr. Rachel Tate uptoTate ( View Tweet)
#EULAR2021 and EULAR IQ
Dr Jack Cush reviews highlight presentations from the first 3 days of EULAR 2021.
https://t.co/BkHjhOUqNU https://t.co/4JS1yGiJHg
Links:
Dr. John Cush RheumNow ( View Tweet)
KEEPsAKE 2: Risankizumab RCT in Bio-IR or csDMARD-IR active PsA. Primary endpoint ACR20 W24 met with 51.3% vs 26.5% in PBO group (P < .001) and ACR50 26.3% vs 9.3%. No particular safety signal.
#OP0228 @Rheumnow #EULAR2021 https://t.co/HZv8qoc4sz
Aurelie Najm AurelieRheumo ( View Tweet)
Serious infections and BioDMARDs: what is the confounding factor?
BSRBR-RA: 33,916 RA treated w/ BioDMARDs with 62,532 years of follow-up, 2036 SI. HR of SI no longer different among BioDMARDs when adjusted for the line of therapy! #OP0241@Rheumnow #EULAR2021 https://t.co/UG9WrXP7RD
Aurelie Najm AurelieRheumo ( View Tweet)
Is Rituximab and Belimumab the Combination to Beat Lupus? by Dr. Eric Dein (@ejdein1) #EULAR2021
On day 2 of EULAR , Dr. Michael Ehrenstein presented OP0129, a presentation on the BEAT-LUPUS trial looking at belimumab therapy after rituximab.
https://t.co/r4aNG7KR5h https://t.co/nppgRytnlr
Links:
Dr. John Cush RheumNow ( View Tweet)
Presenting now at #EULAR2021
#COVID19 outcomes in patients with inflammatory rheumatic and musculoskeletal diseases treated with #rituximab: a cohort study
https://t.co/QTGkiMcC2d https://t.co/DJB6GooPuJ
Links:
The Lancet Rheumatology TheLancetRheum ( View Tweet)
Is #JAKi better on PROs than #Adalimumab in MTX-IR pts with RA? Yes....some. RA BEAM with 4mg Bari >Adalimumab for pain, HAQ, am stiffness but = on fatigue. POS0649 @RheumNow @eular_org #EULAR2021
Janet Pope Janetbirdope ( View Tweet)
Who responds better to bDMARDs in RA, PsA & SpA? Men, women or equal? POS0208 #EULAR2021 @RheumNow @eular_org
Janet Pope Janetbirdope ( View Tweet)
Sex differences in response to bDMARDs in RA, PsA & SpA? YES. Data from BIOREG- 477 RA, 150 PsA, 312 SpA treated with rap TNFi. Men respond better to TNFi in all groups POS0208 #EULAR2021 @RheumNow @eular_org https://t.co/7FoI3p0qwe
Janet Pope Janetbirdope ( View Tweet)
2021 GRAPPA STRONG recs: *⃣Axial PsA/arthritis, biologic-naive or IR: TNFi, IL17i, JAKi *⃣Peripheral arthritis biologic-IR: above + IL23i *⃣Peripheral arthritis DMARD-IR: above + IL12/23i *⃣Peripheral arthritis DMARD-naive: above + PDE4i + csDMARD OP0229 #EULAR2021 @RheumNow https://t.co/Z2Nv073yoU
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Similar efficacy of PsA enthesitis treatment between adalimumab and secukinumab
⭐️mean change and resolution of enthesitis similar
⭐️resolution of equal but ⬇️ in pts with ⬆️ baseline enthesitis activity
⭐️rate of relapse ⬇️ and similar
Abs#POS0194
#EULAR2021 @RheumNow https://t.co/uPE4kmotCY
Robert B Chao, MD doctorRBC ( View Tweet)
#OP0228 Phase 3 RCT on Risankizumab - KEEPsAKE 2 -PsA with 49% prior bDMARD 95% prior csDMARD: week 24 results
PE: ACR20 51% active vs 26% on PLC
PASI90: 55% active vs. 10% PLC
#EULAR2021 @RheumNow https://t.co/UkZLcXTNnq
Paul Studenic Stiddyo ( View Tweet)
