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ICYMI: Your Rheumatoid Questions from RNL 2022 Rheumatologists questions for Dr. Jack Cush QD Clinic is sponsored by RheumNow's PsA All the Way Campaign in April 2022 https://t.co/gNk77DIEKK https://t.co/kxJVvRnmkH

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Study of 221 active RA pts starting a DMARD showed that Sleep disturbance significantly predicted subsequent pain sensitization and conditioned pain modulation. https://t.co/zcUVaMemXN https://t.co/5timIb0aeG

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Your Hot Topic Questions from RNL 2022 Rheumatologists questions for Dr. Jack Cush QD Clinic is sponsored by RheumNow's PsA All the Way Campaign in April 2022 https://t.co/wpPeIwiCxe https://t.co/UY3gDaVeTv

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Heart Risks Elevated in RA Patients Despite Biologic Tx Hopes that biologic drugs for RA would cancel the extra cardiovascular risks normally seen with the disease dimmed a little in the face of findings from a population-based study from Scandinavia. https://t.co/qUYG3U2Ind https://t.co/oCpNnDmxIX

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Systematic lit review of 5694 CTD pts (SLE, RA, IIM, SSc) admitted to the ICU shows overall risk of mortality was 33%. ICU admits mainly for sepsis (43%), flares(40%). Mortality risk was 70% in IIM, 40% SSc, 35% SLE subgroup, 20% RA. https://t.co/ubVujkLCNy https://t.co/nnJdO36imK

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#PsA Biologic initiation was associated with a SMALL drop in NSAIDs (51.1 to 42.5%); glucocorticoids (57.4 to 46.9%) and opioids (38.1 to 33.8%) (Initial vs 12 mos later). Pain Rx use study in 5681 PsA, 2180 AS, & 34,047 RA pts #PsAlways https://t.co/wyrT9CVNq8 https://t.co/8vl7e2a63n

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Korean study shows #RA is assoc w/ a risk of primary open-angle glaucoma, esp within 2 yrs of Dx & if >75 yrs. Study of 2049 older incident RA pts; POAG risk higher in RA than the matched controls (HR 1.44), 1st 2 yrs (HR 1.83), >75 yrs (HR 2.12) https://t.co/IvPw5InSis https://t.co/dkrK6RvRKE

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cancer, melanoma, metastatic, cell

Increased Cancer Risk with Autoimmune Disorders

d Jack Cush, MD

The incidence and mortality of cancer among autoimmune diseases (AID) was studied in a large Chinese cohort, demonstrating that while onset time and risks vary, there is an increased risk of malignancy in AID.

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heart.EKG_.CVD_.jpg

Heart Risks Elevated in RA Patients Despite Biologic Tx

d MedPage Today

Hopes that biologic drugs for rheumatoid arthritis (RA) would cancel the extra cardiovascular risks normally seen with the disease dimmed a little in the face of findings from a population-based study from Scandinavia.

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Your Rheumatoid Questions from RNL 2022 Rheumatologists questions for Dr. Jack Cush QD Clinic is sponsored by RheumNow's PsA All the Way Campaign in April 2022 https://t.co/sHBMKNvoXQ https://t.co/jcQgOIz7xt

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Dr. John Cush RheumNow ( View Tweet)
Free Teaching PDF on "What is Rheumatoid Arthritis" from JAMA https://t.co/EGdq1jbjzJ

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virus,injection,COVID,vaccine

FDA Authorizes 2nd Booster for Older and Immunocompromised Individuals

d FDA

Today, the U.S. Food and Drug Administration authorized a second booster dose of either the Pfizer-BioNTech or the Moderna COVID-19 vaccines for older people and certain immunocompromised individuals.

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Adipokines are associated with CHF hospitalization (HR 1.39) & CVD-related death (HR 1.49) in #RA pts, especially in non-obese RA. This includes High leptin assoc w/ CV-death (HR 1.44) and High FGF-21 w/ lower CAD (HR 0.75) https://t.co/GQx1kzFOIJ https://t.co/M6MF73xPYs

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ICYMI: Environmental Pollutants Ups Autoimmune Disease Risk An Italian environmental study shows that air pollution increases the risk of autoimmune diseases, in particular rheumatoid arthritis, CTDs and inflammatory bowel diseases (IBD). https://t.co/oKdgSZ2jAF https://t.co/WI7aShKR97

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ICYMI: Drugs for Pregnancy Hopefuls A Young Woman has uncontrolled RA, but wants to get pregnant. What do you chose? https://t.co/Sunx8RWRfM https://t.co/hsFNhVfwHd

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RheumNow Podcast square

Lupus Worries (3-25-22)

d Jack Cush, MD

Dr. Jack Cush Reviews the news and journal reports from the past week in RheumNow.com.

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High disease trajectory despite disease control (^HAQ > DAS28) in RA is more likely with higher pain, fatigue & depression. 10 ys study of 2500 RA pts from NOAR, ESPOIR, ERAN) https://t.co/mrB7fog6PD https://t.co/tqm3LPkOdM

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CV,risk,MI,heart,cardiac

Stable Low Risk of Acute Coronary Syndrome in RA

d Jack Cush, MD

A Nordic multinational collaborative study examined the risk of acute coronary syndrome (ACS) in rheumatoid arthritis and found a less than 2 fold increased risk of ACS patients initiating biologic disease-modifying antirheumatic drugs (bDMARDs) with little risk variation with short-ter

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Having the MUC5B promoter variant increases odds of RA-ILD w/ earlier onset in RA, esp w/ older age of RA onset. Mass Gen Biobank study of 1,005 RA pts; MUC5B found in 15% w/ incr risk of RA-ILD (OR 3.34) & RA onset after 55 yrs (OR 1.52) https://t.co/5odVWnpuxo https://t.co/zeKxADTSBZ

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Aging & Inflammatory Rheumatic Dis is a growing Problem: - Multimorbidity drives polypharmacy & compounds safety risks - More malnutrition, sarcopenia & frailty - Phenotype of Rheum Dz changes w/ age - Tx differs for the elderly - Elder RA is undertreated https://t.co/J2q0mEOqDd https://t.co/VfolGeYx6V

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