All News

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The Risk of Tuberculosis with TNF Inhibitors

d Jack Cush, MD

A study from Turkey shows that among 2117 patients treated with a TNF inhibitor (TNFi) the risk of developing TB was 6 fold higher in those treated with a TNFi compared to non-users.

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RheumNow Podcast - Death and Surgery (2-22-19)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com:

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Lupus Microbiome May Drive Disease Activity

d Jack Cush, MD

Silverman and colleagues have published their study of the fecal microbiome of systemic lupus erythematosus (SLE) patients and found roughly five times more gut bacteria known as Ruminococcus gnavus, and that these abnormalities in microbiota can correlate with measures of disease severity i

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Impressive Survival of Interleukin-1 Inhibitors in Systemic Juvenile Idiopathic Arthritis

d Jack Cush, MD

The drug retention rate of interleukin-1 inhibitors (IL-1) used to treat systemic juvenile idiopathic arthritis (JIA) appears to be quite high according to a new study. 

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Safety Warnings for Higher Dose Tofacitinib

d Jack Cush, MD

Pfizer has issued a press release regarding the safety of tofacitinib, citing higher rates of pulmonary embolism and death associated with the use of higher dose tofacitinib 10mg bid in rheumatoid arthritis (RA) patients treated in a long-term safety trial.  

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Remission Unlikely in RA

d Jack Cush, MD

Dr. Marwan Bukhari (editor of Rheumatology) has written an editorial wherein he suggests that true remission is hard to achieve. He notes that "remission as a target is a noble objective that we should all aspire to but we should not chastise our practice if we do not achieve it, as more and more evidence suggests that we should consider it the ideal but not the norm."

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TKR - One or Two at a Time?

d RheumNow

His would-be surgeon tried mightily to talk him out of a bilateral knee replacement. At 340 pounds, the patient's BMI -- above 43 -- was a significant contraindication. 

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For SLE and other pts with photosensitive skin dz: FDA updated regulations for sunscreens—ONLY zinc oxide and titanium dioxide are Generally Recognized As Safe and Effective (GRASE); combo sunscreen-insect repellents are a big NO! https://t.co/KuaJcT6g1s @RheumNow

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k dao KDAO2011 ( View Tweet)

FDAhas added a boxed warning to the label for gout drug febuxostat (Uloric) based on results of a large postmarketing safety study and AAC panel Recs. FDA concluded that there is an increased risk for death with febuxostat compared allopurinol https://t.co/v1ANA3lI0g

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Dr. John Cush RheumNow ( View Tweet)

QD Clinic - Rules for Pregnancy | RheumNow - Share this video A patient on a biologic wants to get pregnant... https://t.co/DhdFLFAR0O

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Dr. John Cush RheumNow ( View Tweet)

A genuine way to engender trust at each visit, is to inquire about something important to the patients life. More impactful, is when you spend time answering, suggesting, guiding them on important health matters not theirs (like sick husband in hospital, death in family, etc)

Dr. John Cush RheumNow ( View Tweet)

The Best Rheums go to the Best Meetings - RHEUMNOW LIVE - March 22-24 2019 Great Fort Worth, TX - Short Lectures, interactive sessions, Q&A panels, TED (like) Talks, digital, streaming and much more. You dont want to miss this meeting! https://t.co/5TVg0Frsbf

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Dr. John Cush RheumNow ( View Tweet)

QD Clinic - When to Stop Anakinra | RheumNow - A Stills patient wants to stop his anakinra - but when is the right time? https://t.co/aI3f6D3mwX

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Dr. John Cush RheumNow ( View Tweet)

QD Clinic - The NP Says the Patient is Flaring | RA patient is Flaring with interruption of Abatacept; the NP want to know what to do. https://t.co/IVhbWwjWrS

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Dr. John Cush RheumNow ( View Tweet)

Check out these cool case presentations from #RWCS2019 Fellows. https://t.co/xJifZ7zXYQ

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Dr. John Cush RheumNow ( View Tweet)

Swedish Population study shows a 2 fold higher mortality in patients with RA and MSK (SMR 2.2 & 1.5) patients with < 9 years of education compared with those with > 12 years of education. https://t.co/bjil9FAe4I

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Dr. John Cush RheumNow ( View Tweet)

A prospective clinical registry examined 1,520 deaths among 12,679 RA participants (80,502 PYs). Mortality was strongly associated with Obesity BMI >30 kg/m2; at age 30 HR: 2.00 (1.65,2.42) p<0.001]. https://t.co/T2VIJgdO0F

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Dr. John Cush RheumNow ( View Tweet)

Review of IL-21 - made by follicular helper T & Th17 cells; promotes B cell maturation/function, mediated thru activation of the JAK/STAT, MAPK, PI3K pathways. IL-21 is increased in autoimmune patients - may be Rx target in RA, SLE, RA, T1D, PsA https://t.co/ld1Q3fHw9N

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Dr. John Cush RheumNow ( View Tweet)

Review of 541,744 total knee replacement (TKR) in Australia (1999-2017) finds lower revision rates in RA vs. OA, but increased risk of infection in RA (esp. males) https://t.co/rIpSFWSNfY

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Dr. John Cush RheumNow ( View Tweet)

Finnish population study of 4180 JIA patients shows JIA mortality not increased (0.6%) vs Nl population. Mmean age at death 20.3 yrs; Most common JIA cause was accidents, vs. suicide in controls. JIA pts had less substance abuse and depression https://t.co/9WiJJPxChR

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Dr. John Cush RheumNow ( View Tweet)

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