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ACR21 Best Abstracts - Day 1
The RheumNow faculty have been glued to their monitors all day, watching video, and running down abstract presentations to find the best – several of these stood out as #ACRBests. Here is a listing of “Best” they saw on Day 1.
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Don't stop hydroxychloroquine in SLE, even when doing well. Associated with ⬆️flare risk. x2 even when in remission. Abstr#0959 #ACR21 @RheumNow https://t.co/1gGx0V5oxk
Richard Conway RichardPAConway ( View Tweet)
CV events go down when #hydroxychloroqine dose goes up in SLE BUT only in non smokers. Maybe due to smoking attention of HCQ levels &/or smoking as a bigger risk for CV over rides HCQ dose? ⬇️cardiac events by 28% in non-smokers abst0871 #ACR21 @RheumNow #RheumPix https://t.co/XxgK7iRXWi
Janet Pope Janetbirdope ( View Tweet)
#ACR21 Rheum Secrets and Pearl
Lupus pernio on the nasal ala.
⭐️Lupus in the name, but this is #sarcoid and not same as perniosis (chillblains)
@Rheumnow https://t.co/r49yjkjsje
Eric Dein ericdeinmd ( View Tweet)
Plenary at #ACR21 Renal outcome Risk of minority patients with pediatric #lupus @rheumnow abst#0956
inpatient hospitalizations. https://t.co/HK8w246Dsn
Bella Mehta bella_mehta ( View Tweet)
#ACR21 Rheum Secrets and Pearls
High CRP - not a typical marker of SLE flare. Look for infection!
@Rheumnow https://t.co/g1Z6OHvANv
Eric Dein ericdeinmd ( View Tweet)
Elevated CRP? Dr. Kolfenbach reminds us that it is not typical of #SLE flares, rule out INFECTION!
@RheumNow #ACR21 #RheumTwitter #MedTwitter https://t.co/FnkPdZ8gSl
sheila RHEUMarampa ( View Tweet)
"We need to do more than improving quality of care to close the gap in racial disparities." - Dr. J Chang
Trends of adverse renal outcomes⬇️w/time in children hosp w/SLE. Improvements seen across racial/ethnic group, but black-white disparity persists abst#0956 #ACR21 @rheumnow https://t.co/HcOwQiKCb2
TheDaoIndex KDAO2011 ( View Tweet)
This slide 👇 from Dr. Mary Crow's lecture shows how 2 categories of autoantibodies with their distinct functions can allow for different therapeutic targets in #lupus
@RheumNow #ACR21 #rheumatology https://t.co/wkthvj21cE
sheila RHEUMarampa ( View Tweet)
#ACR21 Hench Lecture. Wonderful talks by Peggy Crow on #lupus pathogenesis. Tour de force since LE cells discovery. Potential sources of self-nucleic acids:
💠Endogeneous retroelements LINE-1
💠Mitochondria
💠Cell-derived nuclear debris (NETs, apoptotic)
@RheumNow https://t.co/TSdyqblYaA
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Great Hench Lecture from Peggy Crow at HSS! From LE Cell to Interferon: Deconstructing Lupus Pathogenesis
#ACR21 https://t.co/rUxiwKGFqm https://t.co/af2PKrFBv3
Links:
Dr. John Cush RheumNow ( View Tweet)
Obesity does not affect #SLE disease activity despite persistent ⬆️in CRP. From Toronto #lupus database #ACR21 abst#0864 @RheumNow https://t.co/4ZpAMaU0jk
Janet Pope Janetbirdope ( View Tweet)
Attaining low disease activity in #SLE ⬇️ mortality! More time in LLDAS = #lupus low disease activity state = ⬆️survival in >4000 pts with SLE. Also + was clinical remission on treatment CROT. Treat to a target has come to SLE @RheumNow #ACR21 abst0865 #ACRBest #RheumPix https://t.co/8ld8oncFRR
Janet Pope Janetbirdope ( View Tweet)
Dr. P Crow #PhilipHench provides a tour of research on SLE pathogenesis:
👉discovery of Ab to small nuclear RNAs and the spliceosome
👉T cells' role on B cell differentiation
👉⬆️CD40L on SLE lymphocytes
👉IFN genes and their effects on the immune system #ACR21 @rheumnow https://t.co/6v9O19UUxX
TheDaoIndex KDAO2011 ( View Tweet)
Dr. P Crow #PhilipHenchLecture
IFN signature can parallel or predict flares #ACR21 @rheumnow https://t.co/OskxDuKPDH
TheDaoIndex KDAO2011 ( View Tweet)
Soluble urinary ALCAM previously shown as potential biomarker for LN. Further study showing urinary ALCAM trended with changes in renal-SLEDAI and UPCr.
#ACR21 Abst#3053 @RheumNow https://t.co/IqVJej7yda
Links:
Pedro Castillo _Castillo_Pedro ( View Tweet)
Important to discuss men with #lupus
Nationwide claims study showed increased occurrence of multimorbidity in men with SLE compared to women with SLE #ACR21 @RheumNow @AliDuarteMD Abst#0579 #ACRBest https://t.co/ljflGU84Ro
Bella Mehta bella_mehta ( View Tweet)
Ear dyspigmentation, scalp dyspigmentation and scarring alopecia found more frequently in Black DLE pts. Findings may help assist in dx and tx plans. Abs 0598 #ACR21 #RheumNow #ACRbest @RheumNow https://t.co/a1pxWHJ7b5
Dr. Rachel Tate uptoTate ( View Tweet)
Factors associated w/ poor COVID19 outcomes in #SLE from the GRA @rheum_covid
📌Demographics - age, sex, region
📌Glucocorticoid use
📌 Comorbids - renal, CV
📌Untreated/active dse
❗Very important msg here: Control dse, manage comorbids & avoid GCs
@RheumNow #ACR21 abs0866 https://t.co/eXR3KqGrJa
sheila RHEUMarampa ( View Tweet)
#SLE pts will.... answer in abst#0858 #ACR2021 @RheumNow
Janet Pope Janetbirdope ( View Tweet)
