All News
Infection or Disease Flare: What Tools Can Help Differentiate?
Differentiation between a flare of disease and infection in patients with autoinflammatory (AI) conditions, where fever is the hallmark, can be extremely difficult. Few studies have evaluated potential differentiators; and having such tools would meet a huge unmet need.
Read Article
Minority (African American and Hispanic) #SLE patients have worse #COVID19 outcomes – double whammy! Data from the @rheum_covid #ACR21 @rheumnow #abst1933
Bella Mehta bella_mehta ( View Tweet)
#SLE patients with limited health literacy affects vulnerable black patients in multiple domains – worse disease activity/damage, physician/patient communication, worse patient centered care, and patient activation @mithurheum #ACR21 @rheumnow #ACRBest abst#L08
Bella Mehta bella_mehta ( View Tweet)
#ACR21 #Abstr1492 Could gut microbiome contribute to Anti-Ro+/autoimmunity in #lupus? Analyses of 125 stool samples from mother of children with neonatal lupus and/or heart block revealed its potential role in genetic-environment interaction @RheumNow https://t.co/FnJtZJSCRj https://t.co/ttRdP9NIrG
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
#ACR21 Year in Review. Caielli et al. showed in some patients with #lupus, red blood cells retained their mitochondria (Mito+ RBCs) and their frequency correlated with disease activity and blood⬆️IFN @RheumNow https://t.co/ZixgAbOWJ0 https://t.co/hkTWE4m7Ph
Links:
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
#Abstr0076 #ACR21 Can we predict #thrombosis in #lupus patients? Predictors of serology transition at 5yrs:
✅LAC+ to LAC-:Afro-American,HCQ and normal C3
⛔️LAC+ to 🩸Clot:Obesity, low C3 and not on HCQ
Data need in those with Triple Positivity @RheumNow https://t.co/byeL5NjVUS https://t.co/CchtZir2GN
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Either we need to review the Yearly PAP cervical screening in SLE women or work hard to improve patient awareness. Suspect the latter as time between tests was over 4 years late 😱 and 2.7% developed cancer #ACR21 #Abstr0133 @RheumNow https://t.co/wm01MfoFjf https://t.co/blD8WafZsE
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
#ACR21 #Abstr0454 Mortality rate in #lupus nephritis ⬇️by 26% from 1999-2019👏. BUT, racial and residence disparities were concerning; worse in Black, Hispanic, Asian, AI/AN vs White and in large central and medium metro. Residential matters! @RheumNow https://t.co/33vN39acuL https://t.co/XMwN2hXJn7
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
#ACR21 #Abstr0768 We need to improve disparity among all levels of income. Support to the lowest income group seemed to improve but children with #lupus who were in the 2nd level income quartile had the longest length of stay in the hospital #RheumNow https://t.co/7HSveerUhs https://t.co/cSQBELopH5
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Small but important study of LN Class III, IV, and/or V with 6/18 pts considered complete responders by UProt (<500mg/g) continued to⬇️in renal fxn over 5 yrs. Bottom line: even dramatic ⬇️UProt does not tell the whole story.
https://t.co/51x4DlXkJC
#ACR21 Abst#1284 @RheumNow
Pedro Castillo _Castillo_Pedro ( View Tweet)
Infxn risk of 1st year on rituximab for mod to severe SLE vs standard-of-care
🔹Most common SoC Rx: MMF, Aza, and/or cyclophosphamide
🔹🚫significant diff
🔹RTX pts = ⬆️dz duration, ⬆️# of prior meds, ⬇️maintenance steroid dose
https://t.co/AYQFXqlubl
#ACR21 Abst1288 @RheumNow
Pedro Castillo _Castillo_Pedro ( View Tweet)
SLE: Belimumab + standard rx significantly⬇️risk of severe flares vs placebo.
Greatest in those with:
🔹+dsDNA
🔹low C3 or C4
🔹SLICC/ACR Damage index of 0 (argument for early treatment!)
https://t.co/UcGXEklqwJ
#ACR21 Abst#1295
@RheumNow
Pedro Castillo _Castillo_Pedro ( View Tweet)
Dr. Petri on SLE, Vit D, and BMD
~1k pts, 92% fem, 42% Black, 48% White
Freq. of osteoporosis:
💠M ~ F
💠Black ~ White
💠⬆️in smokers
Lumbar BMDs showed:
💠Vit D level w/Paradoxical effect
💠Rec goal of 40ng/mL in SLE
https://t.co/kBylQAwqhD
#ACR21 Abst#1265 #ACRBest @RheumNow
Pedro Castillo _Castillo_Pedro ( View Tweet)
#ACR21 #Abstr1462 More case against Low dose Hydroxychloroquine as could ⬆️ risk of #lupus flares. Adjusted risk as below:
Weight =>80kg, <400mg/d dose (OR 8.3)
Weight <80kg, <300mg/d dose (OR 2.6) @RheumNow https://t.co/bTRMJDoSoI https://t.co/yzopiO3Kbo
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Post hoc analysis of BLISS-LN 🦋
Pts who didn't receive steroid pulses at induction 👇
🔸⬆ PERR & CRR responders, ⬇mean daily pred doses, more pts had ave daily pred <=5mg or <=7.5mg for both BEL & PBO
🔸BEL grp ⬇ flares/kidney-related death
@RheumNow #ACR21 #ACRBest abs1461 https://t.co/ev0LK7d6oL
sheila RHEUMarampa ( View Tweet)
Dr. Furie asked Dr. Touma what he was doing in 1976? Dr. Touma said, "I was not even in school, yet." Dr. Furie noted that in 1976, the first study was published on methylprednisolone pulse for lupus nephritis in 7 patients. #ACR21 @rheumnow Link below https://t.co/Oe9xmH7Tzg https://t.co/xslAHYNXej
TheDaoIndex KDAO2011 ( View Tweet)
#ACR21
#SLE #COVID19
Use of Telemedicine for follow-up of SLE in COVID19
Wait times lower for telemedicine
Patient satisfaction higher in telemedicine group
More hospitalization, higher switch to in person follow up in telemedicine https://t.co/Y21Vki1uDP
Dr. Laura Lewandowski LauraLewMad11 ( View Tweet)
#ACR21
#SLE
SLE – Treatment: New Agents, Old Agents
Pooled data from 2 phase 3 trials (TULIP 1 and 2)
⏬LLDAS is an attainable T2T endpoint in adult SLE trials
⏬Anifrolumab treatment associated with earlier and more sustained LLDAS in adult SLE https://t.co/bxGlVsJOZC
Dr. Laura Lewandowski LauraLewMad11 ( View Tweet)
👉HCQ dose < 400 mg/d are assc with SLE flare. Lower doses of HCQ may decrease risk of retinopathy. 👉For >80 kg (176 lbs), any dose < 400 mg/day is assc with increased odds of flare
(HCQ blood levels not measured)
Abst#1462 #ACR21 @rheumnow https://t.co/5tx3kruT8W
TheDaoIndex KDAO2011 ( View Tweet)
Trauma associates with subsequent increased flares of SLE. Abstr#1446 #ACR21 @RheumNow https://t.co/QeNXOjHAjn
Richard Conway RichardPAConway ( View Tweet)
