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CTD associated ILD đŸ«: lncRNA ENST00000604692 detected in PBMCs is associated with CTD-ILD and can distinguish SSc- ILD and RA-ILD vs. non ILD patients with AUC 0.79. As many lncRNA, unknown if biomarker only or has a pathogenic role. @RheumNow OP0114 #EULAR2022 https://t.co/sR4GmaMkXD
Aurelie Najm AurelieRheumo ( View Tweet)
Burja et al. Dimethyl alpha-ketoglutarate has anti-inflammatory and anti-fibrotic effects on explanted systemic sclerosis skin. @RheumNow #EULAR2022 OP0095 https://t.co/PSbnVh6uta https://t.co/2ij9HgoU6Q

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Richard Conway RichardPAConway ( View Tweet)
✹Localized #Scleroderma Pearls✹ #EULAR2022 Eosinophilic Fasciitis 👉Contractures wrists/ankles, rarely fingers 👉Mimics- #Lipodermatosclerosis #Panniculitis 👉GCs+MTX 1st line (IV in refractory🧐),MMF 2nd line ✅I add IVIg+/-UVA1 (pending logistics and insurance coverage!) https://t.co/ZErfLxgdxd
Ashima Makol MD AshimaMakol ( View Tweet)
Retrospective pregnancy outcome study in 154 Rheumatic pts. Systemic sclerosis pts had higher risk of adverse preg outcomes (vs HC - 60.6% vs 10.0%; OR = 14; SSc had increase in 1st trimester miscarriage, preeclampsia, SGA & Preterm https://t.co/hfd6SsCRmr Conclusions

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Dr. John Cush RheumNow ( View Tweet)

Data from Scleroderma Lung Study (CTX vs MMF in PSS) shows that early progression of ILD by CXR scoring (≄ 2% at 12 or 24 months) experienced significantly worse long-term survival than those with stable Xrays (P = .014). https://t.co/hv2WNJ4Chr https://t.co/W5RIhoIGtT

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Dr. John Cush RheumNow ( View Tweet)
Relevance of Raynaud’s in Systemic Sclerosis A recent analysis suggests that RP should be characterized based on color change and the presence of other symptoms to know whether RP portends more serious manifestations. https://t.co/rLo6Ju5LV1 https://t.co/gAQAYxe9rL

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Dr. John Cush RheumNow ( View Tweet)
PSS.hands_.Raynauds.jpg (keep)

Relevance of Raynaud’s in Systemic Sclerosis

d Jack Cush, MD

Raynaud’s phenomenon (RP) is integral to the diagnosis and management of systemic sclerosis (SSc) patients; a recent analysis suggests that RP should be characterized based on color change and the presence of other symptoms to know whether RP portends more serious manifestations.

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Methotrexate Monitoring (5.13.2022)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. Bad news for digitial ulcers in Systemic sclerosis, Readmissions in Lupus and Thrombocytopenia in APL patients.

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Systemic Sclerosis patients with Digital Ulcers used significantly more healthcare resources per year. Study of 104 SSc pts; w/ DU's had more severe disease, more tests, More HCP/Rheum visits, etc (p˂0.05) https://t.co/wWvrOye92c https://t.co/HsZfSrf5CV

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Dr. John Cush RheumNow ( View Tweet)
Patient,instruction

Making You the Expert of You! (Smart Rules for Patients)

d Jack Cush, MD

You’ve scheduled an appointment with your medical provider - how do you make the most of it? We've gathered these tips and suggestions to share with patients.

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$30 Billion and Counting (4.29.2022)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports and takes viewer questions this week.

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Pregnancy outcomes in systemic sclerosis (SSc) studied in 154 pregnancies from SSc, SLE, APS, & controls (2008 to 2019). Adverse Preg Outcomes APO significantly higher in SSc vs HC (61% vs 10%) w/ more miscarriages, preeclampsia, SGA & preterm births https://t.co/P3uksmJy6V https://t.co/nTtgwjdGgL

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Dr. John Cush RheumNow ( View Tweet)
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Male vs. Female Responders (4.15.2022)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal Reports from the past week on RheumNow.com - including fellowship COVID-19 concerns, the limits of T2T in gout and the real odds of RA remission with your first biologic. 

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Cell has a novel analysis using single-cell analysis of skin/blood from 56 controls & 97 diffuse systemic sclerosis pts, finding stromal abnormalities in LGR5+-scleroderma-assoc fibroblasts (ScAFs). ScAFs are decreased early & progressively https://t.co/Khxejd1fnq https://t.co/OrMAJnPTZt

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Dr. John Cush RheumNow ( View Tweet)
cancer, melanoma, metastatic, cell

Increased Cancer Risk with Autoimmune Disorders

d Jack Cush, MD

The incidence and mortality of cancer among autoimmune diseases (AID) was studied in a large Chinese cohort, demonstrating that while onset time and risks vary, there is an increased risk of malignancy in AID.

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A case–control study from Kaiser, compared obstetric complications in women who later developed Systemic Sclerosis (n=17) vs non-SSc controls (170). Obstetric complications higher in later SSc (71 v 50%) (HTN, PROM, IUGR, NICU, preterm births) https://t.co/4Y4eGuCFJi https://t.co/R4vw90bba4

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Dr. John Cush RheumNow ( View Tweet)
ICYMI: Swedish study found 1774 systemic sclerosis (SSc) pts in 2015 w/ median age 65 yrs (84% women) = prevalence=22.7 per 100,000 . Incidence (2004-2015) was 11.9 per 1,000,000 PYs - incidence remained stable; F were 5x more common than M. https://t.co/NPZUg4CEjA https://t.co/V3H381KpHU

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Dr. John Cush RheumNow ( View Tweet)
ICYMI: Good review of Diagnosis and Treatment of Pulmonary Sarcoidosis in JAMA. - Lung progression (in only 10%) assoc w/ 12-18% 5yr mortality - Sx Sarcoid w/ Lung: start Pred 20 to 40 mg/d for 2 -6 wks - Steroid sparing w/ MTX, AZA or TNFi https://t.co/Ue4V1uAhRF https://t.co/5ap3bPzoNk

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Dr. John Cush RheumNow ( View Tweet)
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Diagnostic Delay in Axial Spondyloarthritis (2.25.2022)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. This week, rheumatologic problems incited by respiratory infections, air pollution and how you live, now where you live.

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Late Onset Scleroderma Renal Crisis: A Case Control Analysis - Dr. Yoon Qiu at RWCS 2022 https://t.co/G1M7Lzhk7P https://t.co/hPRL8WFdUf

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Dr. John Cush RheumNow ( View Tweet)

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