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Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com.
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In the United Kingdom, NICE has looked to the British Society of Rheumatology (BSR) to develop evidence based guidance on the safe use of biologic DMARDs in patients with inflammatory arthritis.
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Secukinumabs (SEC) effect on enthesitis in psoriatic arthritis (PsA) was studied in the FUTURE 2 and 3 studies and SEC was shown significantly reduced enthesitis by more than 65% within 14 week.
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A multinational cross-sectional cohort study suggests that smoking cessation in rheumatoid arthritis (RA) patients is associated with lower disease activity measures, improved lipid profiles and lower rates of cardiovascular (CV) events.
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A Danish registy has shown that the the prevalence of Spondyloarthritis (SpA) diagnosed prior to delivery has increased 5 fold in the last two decades and that SpA is associated with an increased risk of adverse pregnancy outcomes (APO).
Dr. John Cush
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Data from 5 RCTs of 733 pts with systemic necrotizing vasculitis examined risks for serious infection (SIE), finds that 20.2% had SIEs and 2/3 these occured within the first 2 yrs. Age, Lung involvement & 5 Factor Score were independent predictors of SIE https://t.co/imHVsZgVfG
Dr. John Cush
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Propensity Score–Matched Cohort claims study compared 11,248 matched pairs RA pts starting either abatacept or TNF inhibitor. ABA had a signficiantly lower risk of hospitalized infx compared to infliximab (HR 0.63), but equal SIE risk vs ETN or ADA. https://t.co/brid5dAdIh
Dr. John Cush
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Palmoplantar pustulosis has very low prevalence rates (<0.1%), qualifying as an orphan disease, Registry data from US, Denmark, Germany identified 1,435, 751 and German PPP patients, respectively; 14-61% also have Psoriasis, with higher risk of PsA https://t.co/S6r4GtG3bF
Dr. John Cush
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Ultrasound study of 980 #gout pts finds Bone erosions were seen in 44%, with 78.4% of these found in the first metatarsophalangeal (MTP) joint. Independent predictors include age, duration of gout, tophi, US synovitis and and joint effusion. https://t.co/LxjgfM29Xd
Dr. John Cush
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Of 1757 systemic sclerosis patients in the EUSTAR study, 25% had diffuse SSc and 9% had current or previous digital gangrene, 16% had digital ulcers (DUs), not CV risk factors. https://t.co/31ypT1V1zO
Dr. John Cush
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Meta-analysis of 30 studies shows that ACPA-positive RA patients are marginally more likely to achieve EULAR and ACR20 responses with abatacept (RR 1.18; 95% CI 1.03, 1.35), but not with TNFα-i (RR 0.97; 0.86, 1.10) (compared to ACPA-negative) https://t.co/V5CviFVSGt
American College of Rheumatology
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ACR/ARP 2019 attendees get “sneak preview” of updated gout clinical practice guideline → https://t.co/VRyfj75nVu #ACR19
Dr. John Cush
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Metanalysis shows that although MTX may blunt some vaccine responses (eg Pneumococcal), the use of MTX, TNF inhibitors and other biologics should not deter vaccination as most vaccine responses are preserved despite therapy. https://t.co/KINrQMIQkt
Dr. John Cush
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Study of two dietary patterns and the risk of SLE from the Nurses' Health Study (NHS, 1984–2014) and Nurses' Health Study II (NHSII, 1991–2015) shows no association between incident lupus and (healthier) prudent or (less healthy) Western diet. https://t.co/tvX2HqzWxF
Dr. John Cush
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Spinal/SI MRI in the gen. population finds a high frequency of inflammatory and fatty MRI lesions suggestive of axSpA. MRI done in 793 volunteers < 45 yrs (49% males, 8.4% B27+). SI tJ Bone marrow edema in 17%, Vertebra BME 27% & fatty lesions in 81% https://t.co/XOzyWCyLyC
Dr. John Cush
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Norways HUNT study shows NO fracture risk with PPI use in 15,017 women and 13,241 men aged 50–85 years. PPIs were not associated with an increased risk of fracture age-adjusted HR 0.82 (0.67–1.01) for women; 1.05 (0.72–1.52) for men. https://t.co/XIAdvxGTrz
Claire Owen
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In the latest edition of @jrheum, our thoughts on why PMR should no longer be considered a syndrome of shoulder and pelvic girdle pain and stiffness, but rather a chronic inflammatory disease of musculotendinous structures. https://t.co/xtcZEqduhx @drdavidliew @earlyARA https://t.co/J2gqXi3PPw
Philip Robinson
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If you needed more info that smoking isn’t great for #rheumatoid => Smoking cessation is associated with lower disease activity and predicts cardiovascular risk reduction in rheumatoid arthritis patients https://t.co/kg5ns6W65l
Dr. John Cush
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ESPOIR cohort with 172 early seronegative #RA patients finds that early csDMARD use (within 3 mos of Sx) was more likely to predict better outcomes that other prognostic risk (clinical lab or imaging) factors https://t.co/76J93mZ2NH
Dr. John Cush
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Case-control study of 821 #RA cases & comorbidities between 2009 - 2018 shows some occur after RA- epilepsy (OR 2.13), sleep apnea (1.49), pulm fibrosis (4.63); others predispose to RA, IBD (3.82), T1DM (3.07), VTE (1.80) https://t.co/OV1FsAtMH6
