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LLDAS: Predicting Pregnancy Outcomes
Pregnancy in SLE is a high risk situation and active disease can lead to fetal loss, pre-term birth, IUGR and neonatal lupus syndromes. In a study by Dr. Michelle Petri and colleagues, they evaluated whether the LLDAS at the start of pregnancy was predictive of pregnancy outcome.
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ACR20 - Day 3 Report
Here are my highlights from day three, Sunday, of the ACR 2020 Convergence.
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#ACR20 imaging competition: 27 yo F with h/o SLE nephritis s/p kidney transplant p/w abdominal pain due to abdominal wall tophus @RheumNow. https://t.co/iDlF3neIYM
Eric Dein ejdein1 ( View Tweet)
Rheum Now shares Day 3 highlights from #ACR20.
https://t.co/xNv1fG97ib https://t.co/Psa8bRqlVh
Links:
Dr. John Cush RheumNow ( View Tweet)
With Phase 2 of the Accelerating Medicines Partnership study of SLE underway, an #ACR20 session featured a panel that reviewed the methods being used to generate data & discussed some of the findings. Read the recap → https://t.co/hTnCdfBn10
American College of Rheumatology ACRheum ( View Tweet)
@uptoTate @RheumNow Agree. MD global is Often SJC taking into consideration activity severity and location of joints. Ex SJC of two ankles or knees is higher MD global than 2 MCPs. All N of SJC are not =. @RheumNow
Janet Pope Janetbirdope ( View Tweet)
Very low #vitaminD levels <20ng/mL are associated with renal insufficiency in patients with #SLE.
Abs#1789 #ACR20 @RheumNow
https://t.co/dBm3ZlQOso
Mrinalini Dey DrMiniDey ( View Tweet)
Smartphone T2T management of RA & SLE is possible. With over 127,316 DAS28 & 42,593 SLEDAI assessments over 2 yrs. T2T was lowest in spring for both, correlating w/ holidays in China. #ACR20 Abstr#1018 https://t.co/bGJtSTDqzo https://t.co/34za6kokOp
Dr. John Cush RheumNow ( View Tweet)
Dr. Petri et al: Very ⬇ 25(OH)Vit D levels (<20ng/mL) is associated w/ renal insufficiency in SLE
🚨Levels >60ng/mL can ⬆renal insufficiency
This reinforces benefits of Vit.D supplementation (⬇ protnuria; immunomodulation)
@RheumNow #ACR20 abs1789 https://t.co/BJciK77fcp
sheila RHEUMarampa ( View Tweet)
#AerobicExercise improves #Fatigue & #QualityofLife in women w/ #SLE
- ↓Fatigue & ↑overall health after exercise program
- No increase in #lupus activity
- Data may inform understanding of fatigue & exercise interventions in SLE
Abs#1838 #ACR20 @RheumNow
https://t.co/0YtYHrWp6t
Mrinalini Dey DrMiniDey ( View Tweet)
Data from Prof. Michelle Petri's study showed double+ or triple+ aPLs were not superior to single LAC+ for risk of thrombosis in #SLE patients. @RheumNow #ACR20 https://t.co/uDHsbd1Y1k
sheila RHEUMarampa ( View Tweet)
After #COVID19 there may be more #LUPUS due to...@RheumNow @CRASCRRheum #ACR20
Janet Pope Janetbirdope ( View Tweet)
Herpes Zoster Events with Anifrolumab in Patients with Active SLE: An Integrated Analysis of Phase 2 and Phase 3 Trials https://t.co/70oOHXihFb #SLE #zoster x 4-5 times increase in zoster
Peter Nash drpnash ( View Tweet)
@jhrheumatology Michelle Petri MD MPH: thrombosis risk composite score = Low C3 + dRVVT + Platelet C4d. Abst#1513. PltC4d associated with proteinuria, venous/arterial thrombosis. #ACR20 @RheumNow https://t.co/OdAjul5Usg
Eric Dein ejdein1 ( View Tweet)
@andreafava @jhrheumatology shows class switch is common in lupus nephritis biopsy, chronicity scores are critical. Shows value of need for liquid biopsy @rheumnow #ACR20 Abst#1512 https://t.co/M0DWmTLP29
Eric Dein ejdein1 ( View Tweet)
Dr. Crow's #StateoftheArt lecture revealed that BEL may be best used in pts with < 2 years and SLEDAI >10 based on the study from Gatto, M et al from 2020. Does this change how you will use BEL in your practice? #ACR20 @RheumNow
Dr. Rachel Tate uptoTate ( View Tweet)
We were always taught that rheumatic disease ILD is v bad in pregnancy.
Fetal outcomes are def bad in severe ILD, but no maternal deaths/few Cx.
May not need to avoid pregnancy/electively terminate!
Largest-to-date cohort @dukemedicine n=94
@drbags71 #ACR20 ABST1446 @RheumNow https://t.co/E7BDHn8KJb
David Liew drdavidliew ( View Tweet)
This study identified novel RFs for RA-ILD:
Obesity
⬆CRP(≥10mg/L)
Poor function(MDHAQ ≥1)
High education
30py smoking hx assoc'd w/⬆ RA-ILD risk
Do u counsel RA pts on smoking cessation & lifestyle change? @Rheumnow #ACR20 abs1198 #ACRbest @jeffsparks https://t.co/jvZ26n8k5p
sheila RHEUMarampa ( View Tweet)
Another interesting paper looking at screening of AxSpA in AAU patients with chronic back pain. At least 64% patients had confirmed or suspected AxSpA @RheumNow #ACR20 Abstr#1306
Dr. Antoni Chan synovialjoints ( View Tweet)
John Stone: "The HISTORY is the Rheumatologist's scalpel." TA bx is not gold standard in diagnosis, as not fully sensitive. @RheumNow #ACR20.
Eric Dein ejdein1 ( View Tweet)
