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SGLT2 Inhibitors as Gout Treatment

MedPage Today

Patients with gout and type 2 diabetes treated with SGLT2 inhibitors not only had reduced numbers of gout flares, but also lived longer compared with other such patients receiving other medications, researchers said.

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Pizza and Rheumatoid Arthritis (8.11.2023)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from the wonderful wide world of Rheumatology. This week:

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Colchicine or Prednisone in CPPD?

Jack Cush, MD

The COLCHICORT trial in patients with acute calcium pyrophosphate crystal arthritis (CPPD) demonstrated equivalent efficacy for both colchicine and prednisone, yet different safety signals were seen.

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2023 ACR/EULAR Criteria for Calcium Pyrophosphate Deposition Disease

Jack Cush, MD

The prevalence of radiographic chondrocalcinosis is estimated to be 4% to ≥10% in older adults, but the prevalence of symptomatic calcium pyrophosphate deposition (CPPD) disease is unknown. To advance our understanding of CPPD, the American College of Rheumatology and EULAR have published validated classification criteria for symptomatic CPPD disease.

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SGLT2 Inhibitors Reduce Gout Flares and CV Events

Jack Cush, MD

A cohort analysis shows that gout patients initiating sodium–glucose cotransporter-2 inhibitors (SGLT2is) had lower serum urate levels and fewer gouty flares requiring emergency department (ED) visits or hospitalizations.

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"Ask Cush Anything" Returns (7.21.2023)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports and this week, takes on 5 cases/questions from "Ask Cush Anything"

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Pegloticase Plus Methotrexate in Refractory Gout - MIRROR Study 12 mos. Results

Jack Cush, MD

The 12-month safety and efficacy of pegloticase + methotrexate (MTX) in the MIRROR trial shows continued efficacy and tophi resolution after 12 months of therapy.

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ICYMI: 25 Great Women in Rheumatology

Jack Cush, MD

I reached out to many leaders in rheumatology and asked: who are the great women in rheumatology who should be recognized? This was prompted by a smart article in Annals of Rheumatic Disease written by Drs. Tuhina Neogi (Boston) and Nicola Dalbeth (N. Zealand), entitled "Where are the women ‘Heroes and Pillars of Rheumatology’?

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NHANES study of >204 million persons finds 19.6% w/ hyperuricemia (HUC) & 4.1% w/ gout. Gout/HUC pts had higher tisk (HR 2.4) of heart failure (HF), expecially w/ age, DM, CV, & CAD risk factors, & w/ HF, 5-yr survival was 59.9% & 55.9% (1.4x ^ mortality) https://t.co/IrAUHcOV85 https://t.co/2AWhMES28g

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HEALTH DISPARITIES: Lancet study shows from 2000-2019, all-cause mortality was signif. higher in the American Indian/Alaska Native (1028/100K) & Blacks (953·/100K) compared to Whites (802); but lower in Asians (442) & Latinos (595) https://t.co/g8Z3h6BYw8 https://t.co/Ckz1L3O0W7

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Rheums: Have a rheumatology question or case for Dr. Cush? Record it here and we'll feature it on an upcoming podcast. Tell us your name and where you practice rheumatology. https://t.co/uY9Mwyrsn3

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UK-NiCE Guidelines on Gout: Treat to Target to Prevent Irreparable Joint Damage Indications for Urate-lowering Rx: - Multiple/troublesome flares - CKD 3 to 5 - Diuretic Rx - Tophi - Chronic gouty arthritis https://t.co/eUqQpn7QUI https://t.co/eAGTRShYlf

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IL-1β inhibitors can be effective in #Gout. Based on metanalysis of 14 studies(10 RCTs), 4367 gout pts (Rx w/ anakinra, canakinumab rilonacept) Shows CAN, RIL better than active comparator at pain; CAN/RIL reduced gout flares https://t.co/57JSFtLLJD https://t.co/RueDE01jHj

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Dr. John Cush RheumNow ( View Tweet)
SGLT2 Inhibitors Reduce Gout Flares and CV Events A cohort analysis shows that gout patients initiating sodium–glucose cotransporter-2 inhibitors (SGLT2is) had lower serum urate levels and fewer gouty flares requiring ED visits or hospitalizations. https://t.co/fmz1j6pHgL https://t.co/XbqWxZRd97

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Dr. John Cush RheumNow ( View Tweet)
Have a rheumatology question or case for Jack Cush? Record it here and we may feature it on an upcoming podcast. Tell us your name and where you practice rheumatology. https://t.co/vGt12ul6iy https://t.co/044BScmSYc

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Pegloticase Plus Methotrexate in Refractory Gout - MIRROR Study 12 mos. Results The 12-month safety and efficacy of pegloticase + methotrexate (MTX) in the MIRROR trial shows continued efficacy and tophi resolution after 12 months of therapy. https://t.co/8Jhy7gebMD https://t.co/ihZddj7b36

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Dr. John Cush RheumNow ( View Tweet)
In Memoriam: Dr. K. Frank Austen (1928-2023) Rheumatology mourns the loss of a historic leader in the field, Dr. K. Frank Austen, who died at his home in Maine on June 23, 2023, at the age of 95. https://t.co/mtRQ8D5bWt https://t.co/fAQ9ebK95R

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RT @Janetbirdope : Cool way to get peg uricase tolerated in #gout. ##Rapamycin nanoparticle Rx w SEL 212 a uricase -infusion reactions 3.4% - all premeds w steroids and antihistamines- some stomatitis - seemed to lower uric acid and have good tolerability LB0002 #EULAR2023

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Why Patients Don't Take Medicines This report examines the characteristics of adults aged 18–64 who took prescription medication in the past 12 months and did not take medication as prescribed due to cost. https://t.co/zuPgMjKYbh https://t.co/62cG9LDYWi

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2023 EULAR Recommendations on Imaging in Crystal-Induced Arthritis These included 5 overarching principles & 10 recommendations on the role of imaging in making a diagnosis, monitoring, predicting, guiding therapy, and patient education in CiA. https://t.co/tZW3vNCl7T https://t.co/8IB3q3xNY6

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