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ANA+ consult? 2 Yr study of 207 asymptomatic ANA-pos, found only 11% progressed to systemic autoimmune rheum Dz (89% did not). Progressors developed SLE (48%), Sjögren (22%), scleroderma (13%), RA (4%); Arthritis (RR 1.74) more likly in progressors https://t.co/53bmkQ0qj0 https://t.co/8VUxqxnuGl
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Upadacitinib safety across in RA, PsA, AS, atopic dermatitis >15000 Pt-Yrs exposure. Rates (per 100PYs) of Hzoster (1.6–3.6), NMSC (0–0.8) & incr CPK (4.4–7.9) higher w/ UPA vs comparators (RA, PsA); Deaths (0–0.8), SIE (0–3.9), MACE (0–0.4), VTE (<0.1–0.4), CA, malignancies… https://t.co/OoJ5OX7JyL https://t.co/vaMVFmldEB
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Long Term Antibiotics Increase Risk of RA
JAMA has published a population-based retrospective cohort study showing a possible association between the long-term use of antibiotics and the risk of rheumatoid arthritis (RA).
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Dot the "i", Cross the "t" (10.11.2024)
Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com. Today’s reports suggest where to look for help, especially with regard to pain.
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Leiden Early Arthritis Clinic study (2011-17) of 431 pts found when RA is Dx in <12 wks, treatment costs were lower in Seropositive & negative RA. If Dx after 12wks, costs 316% higher in seronegative and 19% higher is autoantibody-positive RA pts https://t.co/I8QqZxIChW. https://t.co/8CRpqRiscz
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A CATCH study of 2052 early RA (ERA) pts found high incidence of hypertension (26%) with the highest risk in older patients with traditional cardiovascular risk factors. Those without HTN, at enrolment, 24% developed HTN after median follow-upof 5 years. https://t.co/8MmU60MK8v https://t.co/LyxSssXKLo
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World renowned faculty delivering state of the art lectures. Early bird registration for RheumNow Live is now open!
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Mucosal Disruptions as Initiators of Rheumatoid Arthritis
The microbiome and mucosal disruptions are believed to play a role in autoimmunity, particularly rheumatoid arthritis (RA). This is linked to the "mucosal hypothesis" of RA. A recent review by Hollers, et al. discusses… https://t.co/79khnkajMy https://t.co/UvZWwJ3ERg
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Appraisal of 2023 ACR RA-ILD guidelines (based on only 3 RCTs). Conditional Recs for MMF, AZA, RTX as 1st-line RA-ILD Rx. W/ RA-ILD progression, options include MMF, RTX, nintedanib, TCZ, CTX, & pirfenidone are conditionally recommended https://t.co/9M3XykPQIi https://t.co/S0TMCsVd4y
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Mucosal Disruptions as Initiators of Rheumatoid Arthritis
Many have suggested that microbiome and mucosal disruptions are contributors to autoimmunity, especially rheumatoid arthritis (RA). This is partly represented in what is known as the "mucosal hypothesis" to RA. A current review article by Hollers, et al. addresses how distinct mucosal endotypes can serve as drivers or initiators of RA.
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Korean population study shows RA was linked to a higher migraine risk, regardless of seropositivity. Comparison of 42,644 RA vs 213,370 controls - found higher risk of migraine (adj HR 1.21; 1.17–1.26). https://t.co/8jlJ4oV95Z https://t.co/r7hsQpt3u7
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Hand-Held Imaging Could Transform Arthritis Care
A new hand-held scanner developed by UCL researchers can generate highly detailed 3D photoacoustic images in just seconds, paving the way for their use in a clinical setting for the first time and offering the potential for… https://t.co/YSCfoWCXpr https://t.co/du6cruFfRQ
Dr. John Cush RheumNow ( View Tweet)
Long Term Antibiotics Increase Risk of RA
JAMA has published a population-based retrospective cohort study showing a possible association between the long-term use of antibiotics and the risk of rheumatoid arthritis (RA).
Read Article
Medical Expenditure Panel Survey study (2018 to 2020) identified 4.27 million adults with RA and found significantly higher (mean $3,382) health care expenditures, particularly prescription medication costs, and was associated with suboptimal quality of life… https://t.co/87os1PWT2F https://t.co/znmkucBIdE
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Hand-Held Imaging Could Transform Arthritis Care
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EurekAlert!
A new hand-held scanner developed by UCL researchers can generate highly detailed 3D photoacoustic images in just seconds, paving the way for their use in a clinical setting for the first time and offering the potential for earlier disease diagnosis.
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Using MRI to Evaluate Knee Pain
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MedPage Today
Interim results from a randomized trial show that middle-aged patients with knee pain and suspected meniscal tears can benefit from MRI scans even in relatively simple cases.
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Have a a rheumatology question or case for Jack Cush? Record it here and we may feature it on an upcoming podcast. Tell us your name and where you practice rheumatology.
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Trends in Early Undifferentiated PolyArthritis presentation. Over 3 eras (1998-2004-245 pts; 2005-10 266 pts; 2011-22 329 pts) many Sxs & Rx same. But Sxs duration 2.9 to 4.1mos, seropositivity 54 to 42%, Erosion score 18 to 9, mostly in Seroneg pts; Steroids incr 18 to 33%… https://t.co/AZfjqB4xGI https://t.co/GEwDWjccxl
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Which One is the Loneliest Number (9.27.2024)
Dr. Jack Cush reviews the regulatory approvals, announcements, guidelines and interesting journal articles from the past week on RheumNow. When not to use muscle relaxants, how frequent is loneliness in RA/PsA/SpA, and when to refer… https://t.co/c4YKKXbweX https://t.co/pEaA5qVvd9
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Full read review and metanalysis of 11 articles shows nearly 60% of #RA demonstrate an elevated Coronary Artery Calcification (CAC) score; RA pts have higher CAC scores (&CV risk) than their healthy counterparts. https://t.co/aWE2Ul6WDu https://t.co/QHFbRzytTZ
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