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Behçet’s Syndrome
A comprehensive overview of Behcet's syndrome appeared in last week's NEJM, reviewing the numerous advances in the immunogenetics, syndrome recognition, and targeted therapeutic approaches.
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CD19 CAR T-Cell Therapy in Autoimmune Disease
The NEJM has published the results of CD19 B cell depletion (by CAR-T cell therapy) in autoimmune disease patients, demonstrating it to be feasible, safe, and efficacious.
https://t.co/ym3pAsI5Sf https://t.co/AnfKOISscV
Dr. John Cush RheumNow ( View Tweet)
RA BIOBADASER registry study of 1128 patients going on ts/bDMARD found 107 (9.3%) w/ multimorbidity (Charlson Comorbidity index ≥ 3). Multimorbid RA were older, more SJC & signif higher DAS28; ts/bDMARD retention rate equal groups https://t.co/am4Uoccla9 https://t.co/P7Ae2Jal2e
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Feb 2024 EMA meeting approved biosimilar ustekinumab (Pyzchiva) for adult/pediatric psoriasis; psoriatic arthritis; UC/Crohn's. & also approved generic Apremilast Accordfor the treatment of psoriatic arthritis, psoriasis, and Behçet disease https://t.co/Cu9f4qQjgP https://t.co/qmH3ZkfReN
Dr. John Cush RheumNow ( View Tweet)
Congratulations to Drs. David Felson Tuhina Neogi of Boston University in being awarded a U19 5 yr grant to fund Novel Insights into Osteoarthritis, Pain and Function: The Multicenter Osteoarthritis (MOST) Study. https://t.co/fGU9Zk2ECs https://t.co/dtT0hu7aA1
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MMPs play pathogenic role in RA-ILD. Multicenter VA study of 2,312 RA pts, 96 had prevalent ILD & Incident ILD developed in 130 (IR 7.5/1,000PY). High MMP-7 increased ILD (adj OR 3.78) & incident ILD (adj HR 2.33). Higher MMP-9 did same https://t.co/3i49TsAQbt https://t.co/RA6Fu2jPeE
Dr. John Cush RheumNow ( View Tweet)
Eating for RA
The majority of practicing rheums at RheumNow Live were unaware of the new ACR guidelines issued in 2022 regarding dietary and lifestyle recommendations for patients with RA. Dr. Monica Guma reviewed these guidelines during her lecture.
https://t.co/9herN2musx https://t.co/P1xJn2lDrg
Dr. John Cush RheumNow ( View Tweet)
Serial plasma samples assayed for 92 inflammation-related proteins, during and after gout attacks. 21 were differentially expressed. Gout flares assoc w/ increased IL-6, CSF-1, VEGF-A & tumour necrosis factor superfamily 14 (TNFSF14 was highest) https://t.co/2p8vTFcmvD https://t.co/5z1gYdsKJO
Dr. John Cush RheumNow ( View Tweet)
Week 52 outcomes of 180 lupus nephritis pts (IV, VI, III) from AMP academic centers (rx w/ standard of care) showed 22% complete resp, 22% partial resp, 42% non-responder& 14% undetermined. 8/180 (4.4%) had CR sustained Wk 12 to 52; 10% PR. An unmet need! https://t.co/MJklf0Xhih https://t.co/w6a1fLKmoF
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Cochrane Review: How Good is Ultrasound Diagnosing GCA?
Is temporal artery ultrasound (US) equivalent or superior to the reference standard of temporal artery biopsy (TAB) when diagnosing giant cell arteritis (GCA)?
https://t.co/AcETp0TJBF https://t.co/eKVmaro7D0
Dr. John Cush RheumNow ( View Tweet)
Vasculitis Pearls
Once again RheumNow Live 2024 really delivered with high impact learning packed into short sessions. As someone with an interest in vasculitis it was fantastic to see four of my favorite speakers in the Vasculitis Mavens and STEP talks
https://t.co/Oee5nRhTAx https://t.co/sJGwCzLUQq
Links:
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How do you manage enthesitis?
Enthesitis can be a challenge for clinicians to identify, evaluate, and manage in patients with psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA).
https://t.co/BlC3onBYSX https://t.co/OXPdZuJHaN
Dr. John Cush RheumNow ( View Tweet)
Long-Term, open-label study enrolled EGPA (MIRRA study) required prednisolone ≥5 mg/d, pts cont mepolizumab 300 mg Sc q 4 wks +SOC. 100 pts - 71% completed, 3% d/C due to AEs. Exposure~38 mos; 38% serious AEs (30/100PYs) (worsening of asthma, EGPA https://t.co/GKxXN8p2Wz https://t.co/TFd9s3tfjK
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Top 5 Clinical Pearls in RA Management
#RNL2024 provided a wealth of clinical insights, particularly in the realm of rheumatoid arthritis (RA) management. Here are the top five clinical pearls from the event's opening session, "Success in RA."
https://t.co/DUalEZbfJB https://t.co/RZsW0SKc4J
Dr. John Cush RheumNow ( View Tweet)
Five Takeaways in PsA/SpA at RNL 2024
Continuing with the theme of clinical pearls, the PsA and SpA speakers also provided a wealth of information. Click the link to read our five key takeaways and clinical pearls.
https://t.co/ekKUl5WelF https://t.co/IdPXd7LR65
Dr. John Cush RheumNow ( View Tweet)
The ARIAA trial tested the utility of IV abatacept in individuals ACPA+ arthralgia patients with subclinical inflammation and showed abatacept to decrease MRI inflammation, clinical symptoms, and risk of future RA development.
https://t.co/PdYLKwT0z9 https://t.co/O8uHxzleIK
Dr. John Cush RheumNow ( View Tweet)
Gabapentinoid use in COPD pts assoc w/ signif increased risk of severe exacerbation. Compared with nonuse, GABA use incr risk of COPD exacerbation when used for epilepsy (HR 1.58), neuropathic pain (HR 1.35), chronic pain (HR 1.49) https://t.co/EyONh9sASh https://t.co/Sr2FyJQzBj
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Immune-Related Adverse Events of Immune Checkpoint Inhibitors - FULL READ overview in Annals of Internal Medicine. irAEs occur from few days to 1 year after ICI initiation; w/ 3-fold higher risk 1st 4 wks & only 7% starting 1 year after ICI https://t.co/jxEAl3rlCd https://t.co/IlmvV5kNfP
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ACR 2023 Poster Available on RheumNow: JAKi Safety and Efficacy Through Week 204 in bDMARD-IR Patients with RA
View long-term extension outcomes from the SELECT-CHOICE study in bDMARD-IR patients with RA.
Sponsored by AbbVie US Medical Affairs. https://t.co/3zEn9a2eml https://t.co/P7QXAmqJ2x
Dr. John Cush RheumNow ( View Tweet)
BC, Canada study of 149,902 new rheumatology referrals showed 31% more referrals 2019–2020 (vs 2010–2011). New inflammatory arthritis increased (28% to 51%), delays decr by 22 days; but time to 1st DMARD in RA decreased by only 4 days (6%) to 62 days https://t.co/LEyWcI6ojn https://t.co/QdL8VP1C6q
Dr. John Cush RheumNow ( View Tweet)