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EULAR Points on Managing Difficult Rheumatoid Arthritis

Jack Cush, MD

A EULAR task force has promulgated several points to consider in managing difficult-to-treat RA. These "points" are unique in directing the rheumatologist's attention to the potential for misdiagnosis and the impact of comorbid conditions on what is perceived as poorly controlled RA.

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Tocilizumab in Refractory Skin and Joint Scleroderma

Jack Cush, MD

The interleukin-6 inhibitor, tocilizumab (TCZ), was studied in a cohort of difficult systemic sclerosis (SSc)  and was shown to be effective in refractory joint and skin disease with good long-term retention rates and disease stabilization.

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Inflammatory Arthritis Impairs Male Fertility

Jack Cush, MD

A new study in Annals of Rheumatic Disease shows that inflammatory arthritis (IA) may impair male fertility, especially during the peak reproductive age when lower fertility rates, higher childlessness rates and more fertility problems were seen.

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Non-Serious Infection Risk with Biologics in RA

Jack Cush, MD

Nonserious infections (NSI) comprise the bulk of all infections seen with biologic therapies; new data from British Society for Rheumatology Biologics Register for Rheumatoid Arthritis shows that while NSI are more common than serious infections, the predictors of NSI are the same as serious infections.

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What Factors Predict RA in First-Degree Relatives?

MedPage Today

Among a cohort of first-degree relatives of patients with rheumatoid arthritis (RA), certain patient characteristics, as well as symptoms, helped predict a possible increased risk for developing the disease, U.K. researchers reported.

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RheumNow Podcast – Booster Shots for COVID (8.13.2021)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com.

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Biologics Reduce Surgical Needs in RA

Jack Cush, MD

In Canada, biologic DMARDs (bDMARDs) were introduced after 2001, and since that time there have been significant reductions in hip and knee arthroplasty (THA/TKA) among patients with rheumatoid arthritis (RA), but not in patients with osteoarthritis (OA).

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More Tea, Less Rheumatoid

Jack Cush, MD

A large cohort study of rheumatoid arthritis (RA) patients shows that regular tea consumption was associated with a lower risk of RA.

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The CDC has reported that mRNA vaccine effectiveness against COVID-19–associated hospitalizations was sustained over 24 weeks; but there is evidence of waning protection amongst the immunosuppressed. https://t.co/UpQjFgKTpE https://t.co/3dQ2jacwJD

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#RA & Driving studied w/ installed auto sensor-based instrumentation - 23 controls compared to 33 RA pts (1292 driving hrs): shows RA & worsening Dz severity assoc w/ poor vehicle control; Braking/accelerating & steering variability liked to CDAI levels. https://t.co/umXGAbuicz https://t.co/EYxVVkzxR8

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Dr. John Cush RheumNow ( View Tweet)
New podcast available for download wherever you get your podcasts! We review the big stories on RheumNow this week. https://t.co/dbX9RN8ji5 https://t.co/WEf7yCR9km

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ICYMI Spirometry study in 2,008 #RA patients - compared to controls, RA has a higher risk of restrictive Lung dz (OR 1.36, 95%CI 1.21,1.52) and obstructive LD (OR 1.21, 95%CI 1.07,1.37) independent of confounders like smoking https://t.co/UWViAZtvYg https://t.co/VhgxascvEG

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Dr. John Cush RheumNow ( View Tweet)
Treatment of RA may be difficult, as it is estimated that up to 10% of patients meet the EULAR definition of difficult-to-treat rheumatoid arthritis (D2T RA). Now a EULAR task force has promulgated several points to consider (PtCs) in managing D2T RA. https://t.co/w4EWHD3RC4 https://t.co/s4q7jpitC8

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Dr. John Cush RheumNow ( View Tweet)
Acute CPPD arthritis -1697 pts compared w/ 6503 controls. CPPD pts were older (74 yrs), 57% female, 81% White; & assoc w/ OA (OR 3.1), male (OR 1.3), RA (2.1), gout (2.8), PPI (1.9), diuretics (~1.5). CPPD less likely in Blacks vs Whites (OR 0.47) https://t.co/U22jBmjWXm

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Dr. John Cush RheumNow ( View Tweet)

Spirometry study in 2,008 #RA patients - compared to controls, RA has a higher risk of restrictive Lung dz (OR 1.36, 95%CI 1.21,1.52) and obstructive LD (OR 1.21, 95%CI 1.07,1.37) independent of confounders like smoking https://t.co/UWViAZL6PO https://t.co/9OBz5ROKhw

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Dr. John Cush RheumNow ( View Tweet)
Analysis of 7815 RA patients (female, 85%) w/ 340 H. Zoster events (309 pts). HZ rates were lower in men vs women 8.5 vs 11 HZ/1000 Pt-Yrs. Zoser Risk factors: incr HAQ (OR 1.51), MTX use (1.58), and biologic use (1.88) https://t.co/p0MTlwgJ8g Conclusions

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Dr. John Cush RheumNow ( View Tweet)

Among a cohort of first-degree relatives of patients with rheumatoid arthritis (RA), certain patient characteristics, as well as symptoms, helped predict a possible increased risk for developing the disease, U.K. researchers reported. https://t.co/7geaJDO8O8 https://t.co/opIu4gXxin

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Dr. John Cush RheumNow ( View Tweet)
Osteoarthritis vs. Rheumatoid Arthritis https://t.co/qvVEcKqNAM https://t.co/WDyIZxoL7v

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Dr. John Cush RheumNow ( View Tweet)
A Top Tweet this Week: A large cohort study of rheumatoid arthritis (RA) patients shows that regular tea consumption was associated with a lower risk of RA. https://t.co/ODTs7PdGTN https://t.co/69mi8IlBdj

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Dr. John Cush RheumNow ( View Tweet)
Symptom eval of 870 1st degree relatives of RA in PREVeNT-RA study - 5% were seropositive & 14% had incr CRP. Sleep probs (20%) & joint pain (18%) most common. Symmetrical small joint pain ~12% higher in RF+ and 11% higher w/ high CRP https://t.co/aYoLX0sZ2p

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