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Burden of BMI on Costs of Musculoskeletal Diseases

Jack Cush, MD

A cross-sectional global study shows a substantial impact of obesity and BMI on the health and economic impact of patients with musculoskeletal (MSK) disorders.

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PsA Til Death Do Us Part (1.20.2023)

Jack Cush, MD

Dr. Jack Cush reviews the highlights from the past week on RheumNow.com.

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Elevated Uric Acid Is Associated With New‐Onset Atrial Fibrillation

Jack Cush, MD

A Longitudinal Swedish study has shown that elevated serum uric acid (SUA) levels has cardiovascular implications and may predict the development of atrial fibrillation (AFib). 

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Lubricin as a Treatment Target in Gout?

EurekAlert!

Many Americans think of gout as a disease from a bygone era, akin to rickets or scurvy. The condition commonly afflicted the rich and royal, including American historical figures such as Benjamin Franklin and Thomas Jefferson.

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Best of 2022: Allopurinol Safety in CKD Patients

Jack Cush, MD

A study in the Annals of Internal Medicine reports chronic kidney disease (CKD) patients can be safely treated with allopurinol without an increased risk of mortality.

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Rheum Drugs & IDSA Guidelines to Treat COVID-19

Jack Cush, MD

The Infectious Diseases Society of America has recently updated its recommendations with regards to the treatment of severely ill, hospitalized COVID-19 infected patients and also about the appropriate use of anti-IL-6, JAKs and colchicine.

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Methotrexate + pegloticase increases response rates in gout

Bella Mehta, MBBS, MS

In abstract 0001 presented at ACR22 Convergence, researchers presented 12-month data from a randomized double-blind placebo-controlled trial of pegloticase with or without MTX.

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Burden of BMI on Costs of Musculoskeletal Diseases A cross-sectional global study shows a substantial impact of obesity and BMI on the health and economic impact of patients with musculoskeletal (MSK) disorders. https://t.co/EZJTnLeaOZ https://t.co/sAOQ3fuq8Z

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Dr. John Cush RheumNow ( View Tweet)
AR882, selective uric acid transporter 1 (URAT1) inhibitor in development, completed a phase 2, 140 pt 12-week PBO controlled trial, where 75 mg/d lowered SUA by 59% (8.6 to 3.5 ) & 42% (8.6 to 5.0 ) in 50 mg dose group - all better than PBO https://t.co/HHzHWj4XQr https://t.co/gJD9hnkFJc

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Dr. John Cush RheumNow ( View Tweet)
UK Database 1,955 breakthrough COVID-19 infxs in 54,576 #gout pts compared to 52,468 w/o gout saw more in gout (adj HR 1.24), also w/ more #COVID hospitalizations (adj HR 1.30) & death (1.36), more so in women. Same for unvaccinated https://t.co/596KvupZxi https://t.co/BJJguQBdin

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Dr. John Cush RheumNow ( View Tweet)
The Daily Mail in the UK features a long review of Hx of #Gout (Disease of Kings) & being on the rise in the UK - features a video interview with Professor Philip Conahan (one of our speakers at RheumNow Live 2023!) https://t.co/dNC71DwXTf https://t.co/ZtmQgx5aHc https://t.co/2D3HE0GFO5

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Cool NEJM Case of Spinal Gout in 82-yr-old woman with 3-wk hx of severe LBP, rigors, anorexia, incomplete urination. Hx of PsA, CKD, CHF treated w/ Humira, HCQ, diuretics. Imaging tophi in spine, responded to steroids and allopurinol. https://t.co/Ny50BLk7H3 https://t.co/OOqjpmc1DA

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Dr. John Cush RheumNow ( View Tweet)
Study of 1141 consecutive gouty pts finds 10 (0.9%) with "Shrinking Toes" in those w/ tophaceous gout (usually MTP1,2) - toe shortening mainly due to lytic bone collapse during articular tophus dissolution (esp in severe gout w/ severe erosions) https://t.co/K0DzvAYoAg https://t.co/JhZWtSK7K4

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Dr. John Cush RheumNow ( View Tweet)
Allopurinol Use Does Not Increase Mortality in Gout w/ Chronic Kidney Disease A trial has shown that allopurinol use dose escalation and achieving target uric acid levels, was not associated w/ increased mortality in patients with gout and concurrent CKD. https… https://t.co/IIBo3aOLio
Dr. John Cush RheumNow ( View Tweet)
Hyperuricemia as a biomarker of severe #PsA? Study of 242 PsA pts 30% had hyperuricemia & 6% had gout. Hyperuricemia was significantly associated with age, comorbidity, perph polyarthritis, Jt destruction, less response to treatment. https://t.co/6uUWYPyFKf https://t.co/9nVj0lYwMO

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Dr. John Cush RheumNow ( View Tweet)
Practical Guidance for the Clinical Rheumatologist in Unplanned Pregnancies Women of reproductive age comprise an overwhelming majority of patients with rheumatic and musculoskeletal disease. https://t.co/45ABQ0e2Qy https://t.co/dhLqzjf9uL

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Dr. John Cush RheumNow ( View Tweet)
National cohort of 20–39-yr old men - among ~1.3 million, 18,473 Dx w/ gout (incidence 3.36/1,000 PY). Developing metabolic syndr doubled #gout risk (aHR 2.31); MetS at all visits had 4x risk (aHR 3.82) & MetS recovery reduced gout risk by 59% https://t.co/bLmf1AL5VI https://t.co/8c47zk6vqu

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Dr. John Cush RheumNow ( View Tweet)
Retrospective study of US National Inpatient Sample data 2015-2019 looked at 60,360 gout admissions, roughly 1/4 had Arrhythmias (mostly older pts; AFib (88%), atr flutter (6.2%), VTach (3.2%). Gout-arrhythmia pts had more deaths (adj OR 2.06) https://t.co/L1WEsybI7h https://t.co/xwAfFVJOuk

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Dr. John Cush RheumNow ( View Tweet)
Methotrexate + pegloticase increases response rates in gout Patients with refractory gout and those with high burden of tophi have only few options when it comes to uric acid lowering agents. https://t.co/8cqsAXuzIB https://t.co/OSpf5ehiCm

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Dr. John Cush RheumNow ( View Tweet)
Follow us on LinkedIn too! https://t.co/iylzzYRVAB https://t.co/7rKQShIzs5

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Dr. John Cush RheumNow ( View Tweet)
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