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Tic-Borne Disorders Causing Chronic Arthritis?
Findings from a population based cross-sectional study suggests that while up to 20% of patients have antibodies to tick-borne exposures, only a minority reported musculoskeletal symptoms.
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2023 EULAR Non-pharmacological Management of Hip and Knee Osteoarthritis: 2023 update
EULAR has published the 2023 updated recommendations for the optimal non-pharmacological management of hip and knee osteoarthritis (OA).
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Sodium Channels, Carbemazepine and Osteoarthritis Progression
A study published in Nature suggests that therapies affecting sodium channels could be employed to treat osteoarthritis.
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Increased CV Comorbidity in Dermatomyositis
A cohort study suggest that patients with dermatomyositis (DM) are at an increased risk for multiple comorbidities, including chronic kidney and cardiovascular disease,
https://t.co/8OhcLL5f6Y https://t.co/zVmyrx2DdI
Dr. John Cush RheumNow ( View Tweet)
Experience the Future of Rheumatology at RheumNow Live 2024, just two weeks away!
Don't miss out – secure your spot today for an unforgettable journey into the latest advancements and insights.
https://t.co/ny6R6QBq0j https://t.co/slHPPOQIDi
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US Retrospective cohort study at 29 academic centers of 2428 adults hospitalized, of whom 550 (23%) had a diagnostic error (Pt assessment or testing) contributed to harm or death in 18%. 1863 pts died, w/ 6.6% having diagnostic error that contributed https://t.co/AN1sQt5A1h https://t.co/ZcDbxcoVWJ
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Burnout! A cross-sectional study of 3024 US physicians, 60% took <=3 weeks of vacation per year, and 70.4% worked while on vacation on a typical vacation day; both findings were associated with higher rates of burnout. https://t.co/M3iFxKNoSE https://t.co/bc6WBkg7Ff
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While NSAID use has been assoc w/ lower risk of cancers (CNS, breast, esophageal, gastric, head & neck, hepatocellular, cholangiocarcinoma, colorectal, endometrial, lung, ovary, prostate, pancreatic); NSAIDs should not be used to prevent cancers https://t.co/YcsU7x7iy0 https://t.co/QJjHqjnuEo
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Retrospective study of 170 #RA on TNFi (Inflx 53%, ADA 28%, CZP 19%). RF, CCP, Drug levels, anti-Drug Abs done.@6 mos HI baseline RF linked to lower drug levels for IFX & ADA; but not CZP. IFX/ADA Hi-RF pts had more dropouts vs CZP (80%/75%/33%, p=0.002) https://t.co/AIgJNkzcWu https://t.co/pQmfmLoFwe
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Hepatitis B Virus Reactivation is possible w/ immunosuppression- most (>10%) w/ w/ Rituximab & stem cell transplants. If HBsAg positive, pts should recv anti-viral prophylaxis; HBsAg− individuals should be evaluated on a case-by-case basis https://t.co/05M28fRXNc https://t.co/38IBMK4gYh
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European ustekinumab (Stelara) biosimilar Uzpruvo® (AVT04) was granted marketing authorisation by European Commission & will be available in July 2024. US FDA approved Wezlana (ustekinumab-auub) in 11/2023. https://t.co/Wv2Z7P5xAu https://t.co/PdGEUpyRU6
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SLE: A Mutated Gene and TLR7 Overexpression
A group of researchers studied four patients from two families who developed symptoms of SLE in the first years of life.
https://t.co/ggr1nMQnh0 https://t.co/c6IoJlgida
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2023 Rheumatology Year in Review
Dr. Jack Cush reviews highlights, advances and hot topics in rheumatology from 2023 and the RheumNow website
https://t.co/5Y9ezzS5zC https://t.co/pqpMR8jDlk
Dr. John Cush RheumNow ( View Tweet)
Real-world data of 5070 RA pts (1816 Rx w/ b/tsDMARDs) showed the use of tsDMARD considerably increased from 2012 to 2021. All b/tsDMARDs pts improved Dz activity & function/ 10 yr effiicacy best for IL6Ri in switch pts and ABA in bNAIVE pts https://t.co/h9j8Pk03if https://t.co/gC7Wloujm0
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Metanlysis of 49 studies, 10 RCTs examined the relationship between RA and non-surgical Rx of periodontitis (NSRT) and in general short term studies show that NSPT benefits RA patients; and DMARD therapy benefits periodontitis https://t.co/HeBA6xtw2O https://t.co/J2QUYVk3gE
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Heritability of Osteoarthritis
A Swedish study examine the genetic contribution to various rheumatic/musculoskeletal diseases (RMDs) and showed that osteoarthritis (OA) had a large heritability compared with other RMDs.
https://t.co/KbQDQ1mB53 https://t.co/opLrlRit2W
Dr. John Cush RheumNow ( View Tweet)
Bidirectional relationship betw Autoimmune disease (AD) & perinatal depression (PND); 1:10 case control study of 1.3 milion pregnancies & 55,299 incident PND found AD preg w/ a 30% (OR 1.3) higher risk of PND & PND had a 30% ^ risk (OR 1.3) of AD https://t.co/zkwIo6liC7 https://t.co/Sy1HPLLeva
Dr. John Cush RheumNow ( View Tweet)
Experience the Future of Rheumatology at RheumNow Live 2024, just two weeks away!
Don't miss out – secure your spot today for an unforgettable journey into the latest advancements and insights.
https://t.co/bbnb97MOHO https://t.co/QXO34ZmP2i
Links:
Dr. John Cush RheumNow ( View Tweet)
QD Clinic - ANA Positivity in RA
Considering an ANA+ Seropositive RA Patient
https://t.co/q0g0JsSWGu https://t.co/nXcEZbbEXG
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Enthesitis, Synovitis, and Tenosynovitis in Psoriatic Arthritis
An ultrasound study suggests that enthesitis is associated with both synovitis and tenosynovitis in patients with Psoriatic arthritis (PsA).
https://t.co/c9z0nsABe0 https://t.co/Ez4i8qCcJ8
Dr. John Cush RheumNow ( View Tweet)