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The incidence and mortality of cancer among autoimmune diseases (AID) was studied in a large Chinese cohort, demonstrating that while onset time and risks vary, there is an increased risk of malignancy in AID.
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Hopes that biologic drugs for rheumatoid arthritis (RA) would cancel the extra cardiovascular risks normally seen with the disease dimmed a little in the face of findings from a population-based study from Scandinavia.
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Today, the U.S. Food and Drug Administration authorized a second booster dose of either the Pfizer-BioNTech or the Moderna COVID-19 vaccines for older people and certain immunocompromised individuals.
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Dr. Jack Cush Reviews the news and journal reports from the past week in RheumNow.com.
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A Nordic multinational collaborative study examined the risk of acute coronary syndrome (ACS) in rheumatoid arthritis and found a less than 2 fold increased risk of ACS patients initiating biologic disease-modifying antirheumatic drugs (bDMARDs) with little risk variation with short-ter
Dr. John Cush
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211 pts presenting w/ hot swollen joint to the ER; 28 w/ septic arthritis; pseudogout 32; gout 50; & others: 101. Predictors of Septic Arthritis: RA (OR 3.4); skin infx (OR 3.3); liver Dz (OR 9.9); knee involv (OR 3.5); immunosuppressive use (OR 3.5) https://t.co/uASovNVOWb https://t.co/Fq3obVDavm
Dr. John Cush
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ICYMI: Your Rheumatoid Questions from RNL 2022
Rheumatologists questions for Dr. Jack Cush QD
Clinic is sponsored by RheumNow's PsA All the Way Campaign in April 2022
https://t.co/gNk77DIEKK https://t.co/kxJVvRnmkH
Dr. John Cush
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Study of 221 active RA pts starting a DMARD showed that Sleep disturbance significantly predicted subsequent pain sensitization and conditioned pain modulation. https://t.co/zcUVaMemXN https://t.co/5timIb0aeG
Dr. John Cush
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Your Hot Topic Questions from RNL 2022
Rheumatologists questions for Dr. Jack Cush
QD Clinic is sponsored by RheumNow's PsA All the Way Campaign in April 2022
https://t.co/wpPeIwiCxe https://t.co/UY3gDaVeTv
Dr. John Cush
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Heart Risks Elevated in RA Patients Despite Biologic Tx
Hopes that biologic drugs for RA would cancel the extra cardiovascular risks normally seen with the disease dimmed a little in the face of findings from a population-based study from Scandinavia.
https://t.co/qUYG3U2Ind https://t.co/oCpNnDmxIX
Dr. John Cush
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Systematic lit review of 5694 CTD pts (SLE, RA, IIM, SSc) admitted to the ICU shows overall risk of mortality was 33%. ICU admits mainly for sepsis (43%), flares(40%). Mortality risk was 70% in IIM, 40% SSc, 35% SLE subgroup, 20% RA. https://t.co/ubVujkLCNy https://t.co/nnJdO36imK
Dr. John Cush
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#PsA Biologic initiation was associated with a SMALL drop in NSAIDs (51.1 to 42.5%); glucocorticoids (57.4 to 46.9%) and opioids (38.1 to 33.8%) (Initial vs 12 mos later). Pain Rx use study in 5681 PsA, 2180 AS, & 34,047 RA pts #PsAlways https://t.co/wyrT9CVNq8 https://t.co/8vl7e2a63n
Dr. John Cush
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Korean study shows #RA is assoc w/ a risk of primary open-angle glaucoma, esp within 2 yrs of Dx & if >75 yrs. Study of 2049 older incident RA pts; POAG risk higher in RA than the matched controls (HR 1.44), 1st 2 yrs (HR 1.83), >75 yrs (HR 2.12) https://t.co/IvPw5InSis https://t.co/dkrK6RvRKE
Dr. John Cush
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Your Rheumatoid Questions from RNL 2022
Rheumatologists questions for Dr. Jack Cush QD
Clinic is sponsored by RheumNow's PsA All the Way Campaign in April 2022
https://t.co/sHBMKNvoXQ https://t.co/jcQgOIz7xt
Dr. John Cush
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Free Teaching PDF on "What is Rheumatoid Arthritis" from JAMA https://t.co/EGdq1jbjzJ
Dr. John Cush
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Adipokines are associated with CHF hospitalization (HR 1.39) & CVD-related death (HR 1.49) in #RA pts, especially in non-obese RA. This includes High leptin assoc w/ CV-death (HR 1.44) and High FGF-21 w/ lower CAD (HR 0.75) https://t.co/GQx1kzFOIJ https://t.co/M6MF73xPYs
Dr. John Cush
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ICYMI: Environmental Pollutants Ups Autoimmune Disease Risk
An Italian environmental study shows that air pollution increases the risk of autoimmune diseases, in particular rheumatoid arthritis, CTDs and inflammatory bowel diseases (IBD).
https://t.co/oKdgSZ2jAF https://t.co/WI7aShKR97
Dr. John Cush
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ICYMI: Drugs for Pregnancy Hopefuls
A Young Woman has uncontrolled RA, but wants to get pregnant.
What do you chose?
https://t.co/Sunx8RWRfM https://t.co/hsFNhVfwHd
Dr. John Cush
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High disease trajectory despite disease control (^HAQ > DAS28) in RA is more likely with higher pain, fatigue & depression. 10 ys study of 2500 RA pts from NOAR, ESPOIR, ERAN) https://t.co/mrB7fog6PD https://t.co/tqm3LPkOdM
Dr. John Cush
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Having the MUC5B promoter variant increases odds of RA-ILD w/ earlier onset in RA, esp w/ older age of RA onset. Mass Gen Biobank study of 1,005 RA pts; MUC5B found in 15% w/ incr risk of RA-ILD (OR 3.34) & RA onset after 55 yrs (OR 1.52) https://t.co/5odVWnpuxo https://t.co/zeKxADTSBZ
