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Drug Naming Games (2.7.2025)
Dr. Jack Cush reviews the news, regulatory and journal reports from the past week on RheumNow.com.
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How can AI be useful for RA pts and rheumatologists?
-AI models have the potential for improving diagnosis, management and outcomes in RA pts.
-Can also improve efficiency and clinic workflow.
-Not so perfect as it sounds (hallucinations, limited accuracy)
#RNL2025 @RheumNow https://t.co/44LUHQ1KPf
Adela Castro AdelaCastro222 ( View Tweet)
AI models require good Positive Predictive Value (PPV)
But: PPV decreases as prevalence decreases
- In choosing a successful biologic:
Harder to predict more challenging patients (multiple failures, co-morbidities, etc) - ACR50 non-response is higher
J Curtis
@RheumNow #RNL2025 https://t.co/SdJ0FHVuSC
Eric Dein ericdeinmd ( View Tweet)
#AI can help with Value Based Care…a year in remission for RA will save a lot of money. @RADoctor @rheumnow #RNL2025 https://t.co/rUpeMrDHZf
TheDaoIndex KDAO2011 ( View Tweet)
Late onset RA (LORA) aka RA diagnosed at an older age — pts have higher inflammatory markers, presents like PMR; they also have polypharmacy, comorbidities, frailty, etc that can complicate management
@UnaMakris #RNL2025 @RheumNow #GeriRheum https://t.co/zqEcyg2ejw
TheDaoIndex KDAO2011 ( View Tweet)
@UnaMakris #RNL25 @RheumNow
Older patients w RA
1/3 of pts onset >60-65
- More acute onset, more systemic, more PMR-like, larger jts
- Higher IL-6, lower TNF-a, less RF, higher ESR
-Co-morbidities, polypharmacy, cognition, depression
Age does not equal frailty, but does correlate https://t.co/5qb60WyKkP
Eric Dein ericdeinmd ( View Tweet)
Rheumatic diseases become more common with aging, dramatically so. @UnaMakris @RheumNow #RNL2025 https://t.co/EXKHP9ufUj
Richard Conway RichardPAConway ( View Tweet)
Can #AI help us determine the
👇
Right drug
At
Right time
Pipe dream?
Or to use #artificial #intelligence term
➡️ a #hallucination?
garbage in ➡️➡️garbage out
Most predictions of drug response are same: multimorbid multiRx failures
Nonadherent poverty #RNL25 @RheumNow https://t.co/70SRp8BnCl
Janet Pope Janetbirdope ( View Tweet)
#RNL2025 is underway! https://t.co/VDEvK70Qg5
Dr. John Cush RheumNow ( View Tweet)
Such an important topic from @UnaMakris . The intersection of aging with our rheumatic disease processes is a crucial area. @RheumNow @RNL2025 https://t.co/n0Kx559g9e
Richard Conway RichardPAConway ( View Tweet)
Are your patients aging with RA, or are they diagnosed with Late Onset RA (LORA)?
-LORA pts tend to present acutely
-High inflammatory markers~PMR Like
-Seronegative/Decreased titers of RF/CCP
@UnaMakris
#RNL2025 @RheumNow https://t.co/aOCwb3lHef
Adela Castro AdelaCastro222 ( View Tweet)
J Curtis #RNL2025 @RheumNow
AI Will Not Replace You
- AI cannot replace human interaction, examination, procedures, interpreting guidelines for an individual, providing empathy, and facilitate good patient education
Will become a tool... but not a replacement to a good clinician https://t.co/qPcNOjWepi
Eric Dein ericdeinmd ( View Tweet)
AI is here to stay! It should be our ally in optimizing patient care and efficiency at work.
Here are the 10 commandments of AI from an amazing lecture from @RADoctor at #RNL2025 #AI #Rheumatology @RheumNow https://t.co/6BajZxGkwe
Links:
Adela Castro AdelaCastro222 ( View Tweet)
Is Rheumatoid Arthritis Becoming Milder?
A 24 year, prospective study analyzing very early rheumatoid arthritis (RA) in three consecutive eras suggests that RA has evolved since 2005, demonstrating less seropositivity, inflammation, and erosions but is characterized by more… https://t.co/y50uCU79i9 https://t.co/crKytLY4WN
Dr. John Cush RheumNow ( View Tweet)
Pain Management in Rheumatoid Arthritis
BMC has published a full read literture review of pharmacological pain management in rheumatoid arthritis, pointing out that the best evidence for pain control comes from the use of DMARDs and treat-to-target strategies.… https://t.co/1rcTxpQxxT https://t.co/s20bg5FJqQ
Dr. John Cush RheumNow ( View Tweet)
QD Clinic - New Palmoplantar Psoriasis and PsA
New Onset Palmoplantar PsO and PsA - what are the options?
Features Dr. Jack Cush.
QD Clinics - lessons from the clinic, sponsored by RNL2025 in Dallas, TX; Feb 8 & 9, 2025
Register at https://t.co/2dcFVgu8z6… https://t.co/3ubBL6HVGF https://t.co/Zdd6Dih5eZ
Links:
Dr. John Cush RheumNow ( View Tweet)
Facing challenges in diagnosing idiopathic inflammatory myopathies? Check out our recent webinar to hear from Stanley J. Naides, MD, FACP, FACR, as he explores the role of autoantibody testing in autoimmune myositis diagnosis and phenotyping. Sponsored by LabCorp Rx. #Myositis… https://t.co/4jMevolO3k https://t.co/ObWPR8QFW2
Dr. John Cush RheumNow ( View Tweet)
TNF inhibitor use did not affect mortality outcomes in 3 cohorts w/ early Cancer (colorectal [514], lung [864], & prostate [603]). 12-20% of CA pts recv TNFi. Overall survival at Yr 1 unaffected in colorectal (HR 0·72; 0·43–1·21), Lung (0·70; 0·49–1·00), Prostate (0·80;… https://t.co/Pi8rNuvioO
Dr. John Cush RheumNow ( View Tweet)
Rituximab is FDA approved for treatment of moderate to severe pemphigus, but 20% may relapse in 1st Yr. Study of 87 pts shows the efficacy of repeat 6 mos RTX in A) those with persistent Dz activity and B) anyone w/ predictors of relapse (PDAI score, DSG1 or DSG3 abs)… https://t.co/IhqdGWVcdp https://t.co/MKhDpa5zHv
Dr. John Cush RheumNow ( View Tweet)
BSR Guideline on Management of Sjögren disease
The British Society for Rheumatology has published its guideline for the management of adult and juvenile onset Sjogren's disease.
https://t.co/UJOvb937lk https://t.co/P77h91nPuN
Dr. John Cush RheumNow ( View Tweet)