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Burnout or Retire (4.12.2024)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com. Is it time to worry about burnout and those who are leaving healthcare?

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ILD Onset in MDA-5 Dermatomyositis

d Jack Cush, MD

Anti–melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis (DM) is a rare, aggressive and progressive subtype of DM.

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GEM: Dysphagia in myositis pts is from skeletal muscle involvement, causing upper pharyngeal dysphagia, but may also manifest as dysphonia, nasal regurgitation, or aspiration (w/ risk of pneumonia). https://t.co/MOyfdCJywC
Dr. John Cush RheumNow ( View Tweet)
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Ides of March (3.15.2024)

d Jack Cush, MD

Dr. Jack Cush has advice for Caesar and the superstitious, and covers pregnancy, platelets, dialysis and vaccinations in Lupus.

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Review article on inclusion body myositis, a progressive, debilitating myopathy w/ onset > 50 yrs. IBM typically has asmmetric, painless, weakness & atrophy of finger flexors or quadriceps w/ dysphagia. Most are wheelchair bound w/in 13-15 years https://t.co/LoWtmDqimu https://t.co/N3OUU7QMc1

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Dr. John Cush RheumNow ( View Tweet)
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Depression and RA (3.8.2024)

d Jack Cush, MD

Dr. Jack Cush reviews the news, journal reports and regulatory approvals from the past week.

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85 pts w/ Myositis by MRI. Abnl MRI patterns correlated w/: - Honeycomb & foggy w TIF1γ or Mi2+, MSA-neg DM/PM, SRP+, HMGCR+ - Honeycomb w Cancer (OR 6.8), Gottrons(OR 8) - Foggy w weakness (OR 11.2) - Dense dot w dysphagia (OR 6.3) & CA https://t.co/kZGuNLFglg https://t.co/lK93U5iY7q

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Dr. John Cush RheumNow ( View Tweet)
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Immunosuppression Increasing (2.23.2024)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from the past 2 weeks on RheumNow.com; but begins with a discussion of what constitutes "immunosuppression" and how it applies to our patients.

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CD19 CAR T-Cell Therapy in Autoimmune Disease

d Jack Cush, MD

The NEJM has published the results of CD19 B cell depletion (by CAR-T cell therapy) in autoimmune disease patients, demonstrating it to be feasible, safe, and efficacious.

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Favorable Survival w/ MDA-5 Ab+. 154 pts w/ MDA5+DM; 40 died (26%) Rx induction (mostly resp. failure). 114 survived, w/ 5-yr survival of 97% & relapse-free survival 77%. Survival improved w/ JAKi use (P=.03). 8% achieved complete drug-free remission. https://t.co/QkqM9IztEG https://t.co/yBCH85CpUN

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Dr. John Cush RheumNow ( View Tweet)
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Autoimmune disease and pregnancy

d EurekAlert!

 For many aspiring mothers with autoimmune disease, pregnancy can be daunting and full of unknowns. In some cases, those suffering from specific autoimmune conditions have chosen to forego pregnancy altogether due to concerns about their disease treatments and adverse pregnancy outcomes.

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Rheumatoid,RA,nodules,damage

SeXXist Reason for More Women with Autoimmune Disease

d EurekAlert!

Somewhere between 24 and 50 million Americans have an autoimmune disease, a condition in which the immune system attacks our own tissues. As many as 4 out of 5 of those people are women.

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Cancer and Myositis #RNL2024 @RheumNow @DrLisaCS on Cancer screening: Risk stratify: dermatomyositis, NXP2, TIFy, <40yo, refractory, dysphagia, cutaneous necrosis at higher risk Enhanced risk stratification for those at risks, versus "basic screening" for lower risks https://t.co/3yy9Fx1pk8

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Eric Dein ericdeinmd ( View Tweet)
Dr Christopher-Stine @DrLisaCS Factors which should influence (some very strongly) your cancer screening approach in myositis @RheumNow #RNL2024 https://t.co/BoyJLrVDwo

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Richard Conway RichardPAConway ( View Tweet)
anti-Sp4 Ab may be protective against cancer in myositis pts who are TIF1-g positive - Dr. L Christopher-Stine #RNL2024 @rheumnow https://t.co/n7Ikn3llGH

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TheDaoIndex KDAO2011 ( View Tweet)
Continue to love this myositis diagram. Seems to be getting ever more complicated though! @DrLisaCS @RheumNow #RNL2024 https://t.co/eXz6144y3y

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Richard Conway RichardPAConway ( View Tweet)
Cancer and Myositis #RNL2024 @RheumNow @DrLisaCS Dermatomyositis risks - TIF1y is highest risk, followed by NXP2 Protective features: childhood onset, ILD, arthralgias Cancer and myositis often present w/in 1 yr before or after Cancer is major cause of death

Eric Dein ericdeinmd ( View Tweet)

Increased CV Comorbidity in Dermatomyositis A cohort study suggest that patients with dermatomyositis (DM) are at an increased risk for multiple comorbidities, including chronic kidney and cardiovascular disease, https://t.co/bYvd5AhqSl https://t.co/4y4kjYhTm3

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Dr. John Cush RheumNow ( View Tweet)
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Methotrexate Nodulosis (1.19.2024)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com. How good (or not) are rheumatologists and what to do about MTX nodulosis?

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Increased CV Comorbidity in Dermatomyositis

d Jack Cush, MD

A cohort study suggest that patients with dermatomyositis (DM) are at an increased risk for multiple comorbidities, including chronic kidney and cardiovascular disease,

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