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Dr. Quotes (11.8.2024)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from this past week from RheumNow.com.

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Gut microbiome changes linked to onset of RA

EurekAlert!

Changes in the make-up of the gut microbiome are linked to the onset of clinically evident rheumatoid arthritis in those at risk of the disease because of genetic, environmental, or immunological factors, suggests research published online in the 

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COVID-19 and Long-Term Risk of Autoimmune and Autoinflammatory Disorders

Jack Cush, MD

A Korean population based study found that people infected with COVID-19, especially severe COVID-19, had an increased risk of autoimmune and autoinflammatory connective tissue disorders.

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Long Covid Defined

Jack Cush, MD

The National Academy of Medicine and New England Journal of Medicine have published a comprehensive definition of "long COVID".

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Advances in the treatment of autoimmune hepatitis

EurekAlert!

Autoimmune hepatitis (AIH) is a chronic, progressive liver disease caused by immune system dysregulation that targets the liver. If untreated, AIH can lead to severe complications, including cirrhosis and liver failure. 

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ANA+ consult (10.18.2024)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal articles from this past week on RheumNow.com.

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Inadequate Zoster Vaccination in Immunocompromised Patients

Jack Cush, MD

A VA study of shows that recombinant zoster vaccine (RZV) vaccination in immunocompromised patients or those receiving immunosuppressive medications is insufficient, given these are high risk individuals.

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Dot the "i", Cross the "t" (10.11.2024)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com. Today’s reports suggest where to look for help, especially with regard to pain.

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Screening to Prevent Multimorbidity in Rheumatic Patients

Jack Cush, MD

A population based screening program of patients with chronic inflammatory rheumatic diseases (IRD) demonstrates that systematic screening IRD patients for multimorbidity increased preventive interventions and reduced hospital admissions. 

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Mucosal Disruptions as Initiators of Rheumatoid Arthritis

Jack Cush, MD

Many have suggested that microbiome and mucosal disruptions are contributors to autoimmunity, especially rheumatoid arthritis (RA). This is partly represented in what is known as the "mucosal hypothesis" to RA. A current review article by Hollers, et al. addresses how distinct mucosal endotypes can serve as drivers or initiators of RA.

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Study on SLE and NMO overlap: Higher risk of acute cystitis & severe sepsis in hospitalized patients SLE/NMO overlap patients 3x more likely to develop acute cystitis 2x more likely to develop severe sepsis #ACR24 @RheumNow abst#1529

Bella Mehta bella_mehta ( View Tweet)

Study on severe lymphopenia in SLE: - Assessed incidence, risk factors, and outcomes - 11.52% of SLE patients experienced severe lymphopenia - Higher infection rates during severe lymphopenia period = No opportunistic infections observed #ACR24 abst#1519 @rheumnow @HSSProfEd

Bella Mehta bella_mehta ( View Tweet)

In case you needed more encouragement for recombinant zoster vaccination in RA patients: it prevents herpes zoster episodes, in the real world. RA pts in KP system n=1926 vaccinated matched 1:3 with non-vaccinated - HZ reduced 60% - PHN reduced 88% #ACR24 ABST0977 @RheumNow https://t.co/BryBrlv9K5

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David Liew drdavidliew ( View Tweet)
Global meta-analysis of 61 studies shows TB Preventive treatment (TPT) - Reduces active TB risk in rheumatic disease patients by 29% (RR: 0.71, CI: 0.57–0.87) - Best outcomes in high TB-burden countries (RR: 0.51) and with isoniazid for >9 months (RR: 0.52). - Dual screening… https://t.co/4P1982ngvL

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Antoni Chan MD (Prof) synovialjoints ( View Tweet)

Infection as a Cause of Death https://t.co/CwvffN7CcM https://t.co/SwSuAanuEO

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Dr. John Cush RheumNow ( View Tweet)
Survey of 779 RA pts in the National Rheumatoid Arthritis Society. Respondents were 95% Caucasian in their 50s with menopause in their 40s. 80% responded that their arthritis was worse during the menopause with 10% being much worse. https://t.co/NqZXK1lLQe https://t.co/k59HD5bKrd

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Dr. John Cush RheumNow ( View Tweet)
Peptic ulcer disease is still assoc w/ signif. hospitalization & mortality (10K deaths in USA/Yr). PUD affects 10% of outpts w/ Upper GI pain. 42% are due to H.pylori, 36% from ASA NSAIDs. Complications bleeding (73%), perforation (9%), pyloric obstruction (3%)- JAMA review… https://t.co/1bgagFVlYN https://t.co/8i2j3r1puf
Dr. John Cush RheumNow ( View Tweet)
Metanalysis of 26 RCTs suggests JAK inhibitors have a low, but signif. increased risk of infections (vs placebo) (RR 1.39; 1.096-1.76). No risk of tuberculosis or hepatitis, but an incr. risk of H. zoster was seen (RR 1.71; 0.84-3.51) https://t.co/kXOcldz46l https://t.co/Y5OWk4W1NZ

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Dr. John Cush RheumNow ( View Tweet)
Is EBV relevant? It's certainly been linked to the etiol of SLE, RA, Sjögrens, & MS. Ronbinson et al suggests "EBV infection as a potentiator of autoimmune rheumatic diseases" and if Rx targeting of EBV may work in EBV-associated autoimmune diseases. https://t.co/bi630VvHTx https://t.co/tKYtwePaTu

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Dr. John Cush RheumNow ( View Tweet)
French cohort study shows that epidermal necrolysis (EN) is a rare, but assoc w/ high rates of in-hospital and postdischarge mortality, esp in elderly and those w/ comorbid conditions. https://t.co/BaMZmer0Fa https://t.co/mrUO419GLP

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Dr. John Cush RheumNow ( View Tweet)
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