Cardiology Anti-inflammatory Trial Fails to Improve CV Outcomes

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Researchers at Brigham and Women's Hospital, Boston evaluated the efficacy and safety of the anti-inflammatory drug losmapimod on cardiovascular outcomes given to patients with a history of myocardial infarction and CV risk factors.

Severe Psoriasis Associated with a Renal Disease Risk

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There have been several reports of psoriasis being linked to chronic renal disease in the literature. Another population-based study has also found a link between severe psoriasis and kidney disease. 

Opioid Use in Rheumatoid Arthritis

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Opioid use and abuse is at an all time high. Epidemiologic and public health analyses have led to greater stringency and attempts to limit use have adversely effected those with arthritis.

Baricitinib Benefits Refractory RA

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The small molecule oral JAK inhibitor baricitinib was effective for patients with highly refractory rheumatoid arthritis, a phase III study found.

Drug Safety Bulletin - March 2016

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RheumNow is committed to reporting safety issues in our monthly Drug Safety Bulletins, wherein we will update you with reports of new, ongoing and resolved Drug Shortages that will affect rheumatology.   If you have suggestions or information about specific drug sho

High Mortal Risk in Rheumatoid Arthritis Following Arthroplasty

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Rheumatoid arthritis (RA) is associated with an increased risk of myocardial infarction (MI) and post-MI fatality compared with the general population. At issue is whether this applies to those undergoing a surgical procedure.

Biologics Are Safe When Used During Pregnancy in IBD

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This is a reposting of an earlier report on RheumNow that includes additional commentary from Dr. Sunada Kane, a gastroenterologist at the Mayo Clinic who specializes in both inflammatory bowel disease (IBD) and pregnancy. 

Week in Review - 25 March 2016

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1. phase 3, BRIDGE study shows romosozumab (anti-sclerostin MAb) significantly increases lumbar BMD in men with osteoporosis


2. Statin use is associated with a 21% increased risk of skin cancer (NMSC) - data

Increasing Polypharmacy and Drug Interactions in Seniors

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Qato and colleagues have published in JAMA a cohort study that examined the use of both prescription and over-the-counter medications among older adults and the frequency of major drug-drug interactions. The study shows the elderly are especially at risk, and the situation is

First Head-to-Head TNF Trial Ends in a Draw

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Comparative efficacy trials may be the best way to make informed treatment choices in a sea of treatment options for rheumatoid arthritis (RA).  Recent years have seen impressive head-to-head (H2H) clinical trials for RA, including AMPLE (abatacept vs.

FDA Approves Taltz for Psoriasis

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Tuesday the FDA approved the IL-17 inhibitor, Taltz (ixekizumab) for adults with moderate to severe plaque psoriasis. (Citation source http://buff.ly/1py10wd) 

Statin-Induced Autoimmune Myopathy

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The CDC estimates nearly 71% of adults with cardiovascular disease and 54% of adults with hypercholesterolemia use a cholesterol-lowering

Differences in Diuretic-Induced Gout

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Diuretics are frequently implicated causes of hyperuricemia and gout.  And there are gout variants wherein age, renal dysfunction and diuretic use may give rise to gouty attack in the hands of women with nodal osteoarthritis.

The Week in Review 18 March 2016

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See the highlights from the past week that appeared on RheumNow.com, and watch Dr. Jack Cush as he reviews each of them. 

January/February 2016 Top Social Media News

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In February 2016, RheumNow published 82 tweets about impactful news, research and teaching points that impact the rheumatology community. These feeds had a reach (impressions) of 80,800 with, 76 mentions, and over 2700 visits to learn on RheumNow.com.

Sclerostin Inhibition May Worsen Rheumatoid Arthritis

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Sclerostin, an inhibitor of the Wnt/β-catenin pathway, negatively regulates osteoblast differentiation and has anti-anabolic effects on bone formation.  Thus, inhibition of sclerostin is currently being studied as therapy for postmenopausal osteoporosis.

TNF Inhibitors Increase Perioperative Infection Risk

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The use of tumour necrosis factor α inhibitors (TNFis) at the time of major surgery has been a challenge for surgeons, rheumatologists and those wishing to develop evidence-based guidelines for this clinical scenario.

IL-6 Inhibition Makes News

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Several new interleukin-6 inhibitors made headlines this week. While none of the new IL-6 inhibitors are soon to be approved and available, these studies may redefine the role of other non-TNF biologics in the future.

The Week in Review - 11 March 2016

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Highlights from this week at RheumNow.com:

Tocilizumab Induces and Maintains Remission in Giant Cell Arteritis

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Lancet has reported the results of a randomized, double-blind, placebo-controlled trial of tocilizumab in patients with new-onset giant cell arteritis (GCA).