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ACR20 - Day 2 Report

Jack Cush, MD

Saturday was the day 2 with many posters and live sessions at the 2020 Virtual ACR/ARP meeting. Here are a few of my highlights from day two:

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Outcomes Switching to Monotherapy: SEAM-RA Trial

Eric Dein, MD

Combination therapy with biologic and conventional DMARDs can be highly effective at inducing remission in patients with RA. Once controlled, patients are often interested in stopping combination drug therapy due to concerns related to medication burdens, side effect profiles, or safety. 

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Who will clot in #Lupus? 150 with SLE, clots ^ if PC4d + = market of plt Activation & arterial thrombosis abstr#1510 needs validation in another SLE group. V interesting @RheumNow @CRASCRRheum #ACR20 https://t.co/UBGxaFwhwZ
Janet Pope Janetbirdope ( View Tweet)
ACR/AF JIA guidelines presented @ACR20: 👉Initiate DMARD early over NSAID monotherapy 👉Use SQ MTX> oral MTX > SSZ/LEF 👉add biologic preferred over triple DMARD 👉DON'T use chronic low dose steroids 👉combo biologic+DMARD > biologic monoRx https://t.co/lwoFSTuV91 @rheumnow https://t.co/wzh2LCS0dN

Links:

k dao KDAO2011 ( View Tweet)
History of IBS, more aggressive disease phenotype & active SpA before conception or during pregnancy increased the risk for adverse pregnancy outcome. #ABS1324 #ACR20 @RheumNow https://t.co/NQ6kDMSaJ3 https://t.co/I3sxRmPL6j

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Dr. Rachel Tate uptoTate ( View Tweet)
821 SLE pts from Hopkins lupus clinic showed that LAC was best predictor of venous + arterial thromboses. β2glycoproteinI IgA (+) also important! #ACR20 #Abstr#1261 https://t.co/H0hz9Gp5Hy https://t.co/Vpiih4LyuZ

Links:

Dr. John Cush RheumNow ( View Tweet)
In our quest to reduce delays to diagnosis in axSpA, this paper in patients with psoriasis, AAU and IBD, the ASAS-modification of the Berlin algorithm was superior to the original algorithm, with enhanced sensitivity @RheumNow #ACR20 Abstr#1303

Dr. Antoni Chan synovialjoints ( View Tweet)

Do you recommend Omega-3 fish oil (2-9 grams per day) to your patients with RA (doubled blinded RCT in 140 pts w/ recent onset of RA showed increased likelihood of achieving remission & less failure of triple therapy in high-dose fish oil group). #ACR20 @RheumNow @LCalabreseDO

Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)

This study shows that serum anti-PAD4, anti-PAD3/4XR abs are highly specific for RA-ILD and assoc'd w/ better lung function in RA-UIP. Small patient sample. Potential prognostic biomarker? @RheumNow #ACR20 abs1200 https://t.co/f5VFjJhVXF
sheila RHEUMarampa ( View Tweet)
Dr Lee reports on risk of melanoma and NMSC risk in RA in cohort study using propensity score matching. No difference in risk between MTX and HCQ overall. Increase BCC in MTX (HR 1.32) but less SCC (HR 0.77) @rheumnow #ACR20 Abstr#1001 https://t.co/LDWgfGK9LS
Richard Conway RichardPAConway ( View Tweet)
Nintedanib in rheum ILD (RA/SSc/CTD) I appreciate the volumes might not seem like much, but: - in first 1y Rx 20% more are spared a FVC decline>10% - biggest diff in UIP-like pattern With the right patient selection, nintedanib does have its place! #ACR20 ABST1048/1049 @RheumNow https://t.co/jGZdR84bBU
David Liew drdavidliew ( View Tweet)
Great thoughts-how do we define seronegative RA as well? more studies like this are needed for patient centered medicine! @ACRheum @RheumNow @OSUWexMed #ACR20 https://t.co/7fUO70t09u

Links:

alexa meara lexmeara ( View Tweet)

Watch my video discussing the SEAM-RA trial of treatment reduction in RA patients in remission on @rheumnow #ACR20 https://t.co/YDfBafBdRs

Links:

Richard Conway RichardPAConway ( View Tweet)

Factors Associated to Clinical and Radiographic Disease Progression in Patients with Early RA and First-degree Relatives: A 1-year Follow-up https://t.co/GWboXit6m1 #RA #firstdegreerelatives obesity and periodontal disease drive risk - both preventable

Links:

Peter Nash drpnash ( View Tweet)

So excited to check out RheumNow’s ACR Mid-Meeting Recap live right now with Dr. Jack Cush (@rheumnow), Dr. Arthur Kavanaugh, Dr. Michale Pillinger, and Dr. Bella Mehta! #ACR20

Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)

Minimum Clinically Important Improvement in Patients with Rheumatoid Arthritis Associates with Gut Microbiome https://t.co/D3ILR57gXY #RA #microbiome that microbiome again

Links:

Peter Nash drpnash ( View Tweet)

Time to Discontinuation of Tofacitinib and TNF Inhibitors in Rheumatoid Arthritis Patients with and Without Methotrexate: Real World Results from a Rheumatoid Arthritis Cohort https://t.co/ZzhE0J7dOX #TOFA #TNFi TNFi does better with MTX Tofa less necessary

Links:

Peter Nash drpnash ( View Tweet)

Etanercept monotherapy significantly more effective than Methotrexate monotherapy in maintaining remission in RA patients on combination therapy. Data from the SEAM-RA study @RheumNow #ACR20 Abstr#0939 #ACRbest

Dr. Antoni Chan synovialjoints ( View Tweet)

Rheumatoid arthritis and lung disease in the spotlight at #ACR20 by @jeffsparks https://t.co/0Dth0k6uve https://t.co/pGfGtq8Sz7

Links:

Dr. John Cush RheumNow ( View Tweet)

After the SEAM-RA study, in patients taking MTX and ETN in sustained remission would you? #ACR20 @rheumnow

Richard Conway RichardPAConway ( View Tweet)

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