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Goofy But True

Jack Cush, MD

Dr. Jack Cush discusses declining survival rates in the USA, FDA approvals of new COVID subvariant boosters and other odd and possibly true new research reports from the past week on RheumNow.com.

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MTP1,gout

NICE Guidelines on Gout Diagnosis and Management

Jack Cush, MD

NICE (UK) has systematically reviewed current medical evidence and delivered a set of recommendations with consideration of cost effectiveness.

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Managing JDM with Calcinosis

Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow and discusses a case of refractory juvenile dermatomyositis with calcinosis.

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gout.MTP1_.jpg

Black Adults Have a Higher Gout Risk

Jack Cush, MD

In a cross-sectional study of US adults, gout was more prevalent in black adults compared to white adults; possibly explained by sex-specific dietary differences and social determinants of health and clinical factors. 

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CV,risk,MI,heart,cardiac

Gout Flares Up Cardiac Risks

Jack Cush, MD

A large case-control study showed that gout patients who experienced a cardiovascular (CV) event were more likely to have had a recent (< 120 days) gout flare compared to those without CV events.

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ACR RISE Registry, 9,560 gout pts- ONLY 56% of patients had > = one Serum Urate recorded during the year; amongst those w/ 1 SU recorded, 74% achieved the SU target. ONLY HALF? GETTING SUAs? Are we not Rheums? https://t.co/OfKRWtyjBT https://t.co/8kjwEVZwB3

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Dr. John Cush RheumNow ( View Tweet)
NICE Guidelines on Gout Diagnosis and Management NICE (UK) has systematically reviewed current medical evidence and delivered a set of recommendations with consideration of cost effectiveness. https://t.co/a8iyCe3szJ https://t.co/6Jy7dOT4yX

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Dr. John Cush RheumNow ( View Tweet)
Gout: diagnosis and management—summary of NICE guidance https://t.co/tVHkSMusk6 https://t.co/A7U1DlI7tO

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Dr. John Cush RheumNow ( View Tweet)
MIRROR study lead to pegloticase (PEG) label change - adding MTX as Rx to reduced anti-PEG Abs. Based on 14 refractory gout pts given MTX 15mg/wk (w/ folate) and then PEG IV: 3 nonresponders, 1 dropped out, 10 responded/stayed on Rx x 52 wks w/ less ADAbs https://t.co/BZwY7DpmIb https://t.co/gNhhuhmTG5

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Dr. John Cush RheumNow ( View Tweet)
✅ Probably one of my most important slides ⬇️ WHY IS MY #TREATMENT NOT WORKING (or not working enough) 😭 This is really a question we're dealing with everyday in #rheumatology when taking care of patients with #autoimmune and other rheumatic diseases 👍 https://t.co/osUPYSvuWf
Laurent ARNAUD Lupusreference ( View Tweet)
ALL-HEART study presented in Barcelona at ESC Congress 2022 showed that allopurinol given to 5,721 older adults without gout, failed to reduce # nonfatal myocardial infarction, nonfatal stroke or cardiovascular death in ischaemic heart Dz pts https://t.co/I0dFXQa6Ao https://t.co/8IevQ4uwUY

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Dr. John Cush RheumNow ( View Tweet)
Eval of 161 acute mono/oligoarthritis pts (gout, CPPD, controls) shows US of 2 joints (target jt, knee, MTP1, wrist) showed Dx accuracy (>90%), high specificity for gout (0.92-0.96) & CPPD (0.90-0.97); w/ sensitivity ranged from 0.73 to 0.85 for gout https://t.co/hW3pmz86kH https://t.co/IFVpINgybY

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Dr. John Cush RheumNow ( View Tweet)
Gout T2T: Rheumatology societies target urate <5 mg/dl (0.30 mmol/l) or <6 mg/dl (<0.36 mmol/l) - below point of urate saturation -->MSU crystal dissolution. Achieving target reduces flares & tophi; but these clinical benefits take time. https://t.co/bR0vh01mvP https://t.co/JFJ1EWAhoF

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Dr. John Cush RheumNow ( View Tweet)
MSK US in Gout? 71 gout pts on ULT followed x 1yr, 42% had at least one flare (median=2). Baseline US showing MSU deposits & inflammation significantly assoc w/ with # Flares (MSU score RR 1.17; power Doppler score RR 1.29) https://t.co/6IQo4JWtK0 https://t.co/Slm0fOvbnt

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Dr. John Cush RheumNow ( View Tweet)
Gout T2T: Rheumatology societies target urate <5 mg/dl (0.30 mmol/l) or <6 mg/dl (<0.36 mmol/l) - below point of urate saturation -->MSU crystal dissolution. Achieving target reduces flares & tophi; but these clinical benefits take time. https://t.co/qfFSpGCJZp https://t.co/ILMAX3jj50

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Dr. John Cush RheumNow ( View Tweet)
Rheums! Do you have a rheumatology question or case for Jack Cush? Record it here and we may feature it on an upcoming podcast. Tell us your name and where you practice rheumatology. https://t.co/cvmbzknQqA https://t.co/6mX5eRUNuU

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Dr. John Cush RheumNow ( View Tweet)

Intensity and longevity of SARS-CoV-2 vaccination response in patients with immune-mediated inflammatory disease: a prospective cohort study https://t.co/1fiNgBQUbr looks like lower ab response and drops over 6 mths - boosters important in our patients

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Peter Nash drpnash ( View Tweet)

Gout Flares Up Cardiac Risks A large case-control study showed that gout patients who experienced a cardiovascular (CV) event were more likely to have had a recent (< 120 days) gout flare compared to those without CV events. https://t.co/HVmHZ0Pi7I https://t.co/XhdLTed5mr

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Dr. John Cush RheumNow ( View Tweet)
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