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Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com.
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In Canada, biologic DMARDs (bDMARDs) were introduced after 2001, and since that time there have been significant reductions in hip and knee arthroplasty (THA/TKA) among patients with rheumatoid arthritis (RA), but not in patients with osteoarthritis (OA).
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A large cohort study of rheumatoid arthritis (RA) patients shows that regular tea consumption was associated with a lower risk of RA.
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A large, single-rheumatology center analysis of oral and subcutaneous (SC) methotrexate (MTX) use in daily clinical practice suggests that SC MTX has fewer drug discontinuations and is better tolerated compared to other DMARD therapies.
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A retrospective cohort study examined the need for joint replacement surgery in juvenile idiopathic arthritis (JIA) and showed there has been a trend to delay arthroplasty over time. The JIA category, year of implant, and presence of complications significantly affected implant survivorship.
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Post-vaccination disease flares were uncommon among patients with rheumatic and musculoskeletal diseases who were inoculated against COVID-19, researchers found.
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A retrospective analysis of the ACR RISE registry shows that multimorbidity is not only common in patients with active rheumatoid arthritis (RA), but also impacts treatment choices and outcomes.
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A prospective, longitudinal study of the cognitive development of children born to mothers with rheumatoid arthritis (RA) demonstrates normal development as measured by comparative school test scores.
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"Fibromyalgianess" is highlighted as a risk factor for undue, extended glucocorticoid use in rheumatoid arthritis (RA) patients, according to Wallace and colleagues in Rheumatology.
Dr. John Cush
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Osteoarthritis vs. Rheumatoid Arthritis
https://t.co/qvVEcKqNAM https://t.co/WDyIZxoL7v
Dr. John Cush
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A Top Tweet this Week:
A large cohort study of rheumatoid arthritis (RA) patients shows that regular tea consumption was associated with a lower risk of RA.
https://t.co/ODTs7PdGTN https://t.co/69mi8IlBdj
Dr. John Cush
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Symptom eval of 870 1st degree relatives of RA in PREVeNT-RA study - 5% were seropositive & 14% had incr CRP. Sleep probs (20%) & joint pain (18%) most common. Symmetrical small joint pain ~12% higher in RF+ and 11% higher w/ high CRP https://t.co/aYoLX0sZ2p
Dr. John Cush
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Pfizer has another JAK inhibitor - ritlecitinib - shown to be effective (vs PBO) in alopecia areata in the Phase 2b/3 ALLEGRO trial. Ritlecitinib is also being studied in vitiligo, rheumatoid arthritis, Crohn’s & ulcerative colitis. https://t.co/ccx0eRXuTS https://t.co/fApTP7WaYU
Dr. John Cush
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"Fibromyalgianess" is highlighted as a risk factor for undue, extended glucocorticoid use in rheumatoid arthritis (RA) patients, according to Wallace and colleagues in Rheumatology.
https://t.co/uv19GSZsBV https://t.co/aSFlV9zeGt
Dr. John Cush
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Registry data suggests an increased risk of herpes zoster (HZ, shingles) in rheumatoid arthritis (RA) patients taking JAK inhibitors (JAKi) but also with other biologic DMARDs, compared to csDMARDs.
https://t.co/Uu1VjAbKMi https://t.co/uGvTyLExjf
Dr. John Cush
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The ARTIS Study Group has published their analysis of (non-skin) cancer risk in rheumatoid arthritis, claiming the overall safety of biologic DMARDs and targeted synthetic DMARDs (tsDMARDs).
https://t.co/RNWrLR53Wx https://t.co/mMmKKrX9vx
Dr. John Cush
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Worth another share--
Turning the Corner on CV Risk in Rheumatoid Arthritis by Richard Conway ( @RichardPAConway) #EULAR2021
https://t.co/S0ownscRKv https://t.co/7QtynRKAd6
Dr. John Cush
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Pain Persists in RA, Even Without Inflammation
One-third of patients with rheumatoid arthritis had unacceptably high levels of pain 5 years after diagnosis, often despite low levels of inflammation, Swedish researchers found.
https://t.co/K8zf1pE9jM https://t.co/aEBu7jVHft
Dr. John Cush
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Swiss SCQM registry compared 3217 RA & 819 PsA pts; PsA had more obese (36.5% overweight, 23.8% obese) than RA (4.4% underweight, 31.8% overweight, 17.0% obese). Obese PsA had higher CRP, Dz activity, worse QOL, pain & skin https://t.co/UzbKlT3tSz
Dr. John Cush
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Comparison of 1040 elderly-onset RA (EORA) and 710 non-EORA patients showed similar disease activity, DMARD choices, drug response rates and reasons for Rx discontinuation - There's no reason EORA shouldn't be treated as aggressive as all RA! https://t.co/P2gpPlJVZE