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ACR Best Abstracts - Day 1
The RheumNow faculty reporters have been glued to their monitors all day, viewing video, reading and listening to abstract presentations and I charged them to earmark those presentations were the “Best” they saw today. Below is the list of most often noted #ACRbest abstracts from Day 1.
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This convinces me! #TNF inhibitors vs #JAKI
great debate at #ACR20 https://t.co/Xb8KkmDJ8f
KenWarringtonMD MdWarrington ( View Tweet)
Scoring hand x-rays for Sharp scores is painfully tedious and not always perfectly consistent.
Why not get a computer to do it? Turns out you can - a deep adaptive machine learning model does as well as a human, each x-ray in literally one second.
#ACR20 ABST0493 @RheumNow https://t.co/SvqkaFy8XZ
David Liew drdavidliew ( View Tweet)
Zonulin levels ⬆ in pre-RA/RA pts; activation of zonulin signalling leads to ⬆ intestinal permeability.
Leaky gut - potential therapeutic target for RA?
@RheumNow #ACR20 abs#492 https://t.co/C4TVrWwcYG
sheila RHEUMarampa ( View Tweet)
UK Biobank data: RA is associated with not just restrictive but also *obstructive* patterns on spirometry/PFTs (independent of smoking).
Consistent observation; direction of causality? The lung in RA continues to fascinate.
Prisco @jeffsparks et al #ACR20 ABST0491 @RheumNow https://t.co/LcjtAefnVF
David Liew drdavidliew ( View Tweet)
Methotrexate and Nonalcoholic Fatty Liver Disease: Dr Eric Dein (@ejdein1)
Dr. Eric Dein discusses the findings of abstract #0181 at the #ACR20 annual meeting.
https://t.co/TzbRRbw1Kf https://t.co/vK6EahTyQ8
Links:
Dr. John Cush RheumNow ( View Tweet)
VA Population study shows that incident RA was less common in persons w/ HIV (PWH)(matched w/ uninfected). Only 21 RA pts in 56K PWH. PWH+/RA+ have lower autoantibodies and less likely to get DMARDs. #ACR20 Abstr#0195 https://t.co/rERJVQfq7a https://t.co/g5lATtxqOM
Dr. John Cush RheumNow ( View Tweet)
Shoutout to @SattuiSEMD and @NavarroMillanMD showing #dementia is lower in #RA pts on bDMARDs compared to csDMARDs using CMS data #ACR20 ABS#0488 @RADoctor @RheumNow https://t.co/1XOV2zqKko
Bella Mehta bella_mehta ( View Tweet)
How do you treat ACPA+, subclinical synovitis (US/MRI+)? Abst#0481 reviews 3 cohorts for progression to clinical inflam arthritis. 44-68% did not progress to IA in 1 year, is DMARD over treating? #ACR20 #ACRBest @RheumNow
Eric Dein ejdein1 ( View Tweet)
Sustained remission is rare, should we settle for sustained low disease activity? Abst#0480 ESPOIR Cohort says no, get remission if possible for better radiographic (Sharp) and fxnal (HAQ) scores. Maybe perfect isn't enemy of good? @RheumNow. #ACR20 https://t.co/QNQn9n27rm
Eric Dein ejdein1 ( View Tweet)
Early RA pts may develop chronic widespread pain. Not all have fibromyalgia. Multiple areas of pain & inflammation ^ chronic pain & other factors ie women high initial pain longer symptoms @CRASCRRheum @RheumNow #ACR20 abstr#187 1/3 at onset have regional pain 1/4 at 1yr https://t.co/7qOxH4h7Dd https://t.co/IFO1uwyR0o
Janet Pope Janetbirdope ( View Tweet)
#ACR20 Basic Science Year-in-review Really important work by @danaorange showing PRIME cells can predict flares in #RheumatoidArthritis patients #HSSrheum @RheumNow
https://t.co/XTqqinAN2a https://t.co/24HkqgHS0H
Bella Mehta bella_mehta ( View Tweet)
#ACR20 year in review by @JYazdanyMD latest data PEXIVAS and SEMIRA trials on corticosteroids - would you change your clinical practice to minimize even low dose Corticosteroids in RA and Vasculitis? @RheumNow
https://t.co/l7PTyANpjq
https://t.co/MRGbsjaGae
Bella Mehta bella_mehta ( View Tweet)
The #ACR20 Great Debate is on! One issue point is lab monitoring on TNF vs JAK. What's your take? @RheumNow
Eric Dein ejdein1 ( View Tweet)
Who can have sustained DMARD-free remission (SDFR)? Abst#0479 says early DAS response after DMARD initiation in ACPA-negative patients #ACR20
@RheumNow. Who do you try for DMARD-free intervals? https://t.co/EOfPt4YQAu
Eric Dein ejdein1 ( View Tweet)
Perform (annual) skin exams in patients in MTX based on discovery of a new adverse effect signal with use of low dose MTX (median dose 15 mg/wk) with a NNH of 167! Screening 160 RA patients on MTX will identify 1 skin Ca. Amazing #ACR20 Year in Review by @JYazdanyMD. @RheumNow https://t.co/hUCzKSYZnB
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Abst#0142 at #ACR20, a post-hoc analysis of FINCH2, shows that filgotinib (FIL)(Jak1-i) + csDMARD improved the degree of activity impairment in a clinically relevant manner compared to placebo + csDMARD in pts w/ inadequate response to bDMARD . @RheumNow https://t.co/6M42LUVuht
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
ACPA in patients with RA are multireactive. How can one antibody bind to so many proteins? ACPA recognize very small linear epitopes shared by many posttranslationally modified proteins.
2F012. Antibodies in RA. #ACR20. <TK https://t.co/OUqshFoxSb
ARD & RMD Open ARD_BMJ ( View Tweet)
#hydroxychloroquine is not a ‘cutie’ drug. E Park et al showed that HCQ does not increase QT interval in RA & SLE patients including if on other meds that may affect QT but known heart disease excluded from study #ACR20 #ACR2020 @RheumNow abstr#432 @CRASCRRheum https://t.co/FGVPknmj5q
Janet Pope Janetbirdope ( View Tweet)
Sustained DMARD-free remission (SFDR) seen in ACPA- RA pts; DAS levels at 4mos. predictive for SFDR. ACPA+ pts no relation w/ SFDR & DAS course @RheumNow #ACR20 Abstr#479 #ACRbest https://t.co/kko4tO7s1Y
sheila RHEUMarampa ( View Tweet)
