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Thrombotic Risk in Rheumatoid Arthritis Linked to Disease Activity

Oct 11, 2020 9:48 pm

A large RA cohort study from the Swedish Rheumatology Quality Register shows a higher risk of venous thromboembolism (VTE) in rheumatoid arthritis (RA)  and that risk is linked to RA disease activity. 

This Swedish national registry included 46 316 RA patients (322 601 visits) enrolled between 2006 through 2018 and collected outcomes and disease activity (DAS18-ESR) measures. This risk of was compared to an age, sex and geographically matched general population.

The overall risk of VTE in RA was 1.88 times higher than controls (risk ratio 1.88; 95% CI 1.65 to 2.15), based on 2241 incident VTE events in RA and 5301 VTE events in the general population cohort.

In RA patients, the VTE risk increased with increasing RA disease activity, with lower rates (0.52%) following remission visits compared to higher rates (1.08%) following visits with DAS28 ESR high disease activity (RR=2.03; 95% CI 1.73 to 2.38).

The authors suggest that RA disease activity can be used as an additional tool for VTE risk stratification in patients with RA.

The author has no conflicts of interest to disclose related to this subject

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