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#ACR23 Abstr# 2488 Phase 2 RCT #SLE showed more patients on ABBV-599 HD (elsubrutinib (BTK-i) + UPA (JAK-i)) and UPA monotherapy met primary & secondary endpoints vs PBO at WK48W. No major malignancy/VTE concerns. No added superiority by adding BTK-i vs UPA alone @RheumNow https://t.co/MUN2o75gEE
Md Yuzaiful Md Yusof ( View Tweet)
During "Rashes in Rheumatology talk at #ACR23, Dr. Katherine Shaw does not routinely use HCQ for DM skin manifestations.
⭐️Only ~10% of DM patients respond to monotherapy with HCQ but potential increased risk of hypersensitivity, especially in MDA5-DM
➡️Suspect that slight HCQ… https://t.co/aRmFmzuAum
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
HCQ and risk of retinopathy 👁️
DoD database HCQ 44000+ females & 10000+ males
Risk retinopathy HR 1.5
Variations according to diagnosis SLE higher risk vs. RA, more so in males HR 2, females HR 1.7
No adjustment on HCQ dose
@RheumNow #ACR23 ABST2452 https://t.co/TtTu6ixb45
Aurelie Najm ( View Tweet)
@md_chawla @RheumNow https://t.co/PVxox5t8ZH
Links:
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
@md_chawla @RheumNow https://t.co/qSdT7by1Vh
Links:
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Erosive hand #OA may be more painful than treated #RA patients. The burden of OA is often not alked about, and this study highlights it! @RheumNow #ACR23 https://t.co/jLbvtMmgE0
Bella Mehta bella_mehta ( View Tweet)
#ACR23 Abstr# 2489 I can’t wait for Phase 3 RCT results as I have many #SLE patients with refractory cutaneous lupus. Post-hoc analyses of Phase 2 RCT of Deucravacitinib showed its efficacy (CLASI-50) over PBO across all CLE subtypes @RheumNow https://t.co/G7edkAU18J
Md Yuzaiful Md Yusof ( View Tweet)
And to continue
B-SAFE Clinical risk score for HCQ retinopathy 👁️ 10 years
4000+ pts, 3% retinopathy over 5yrs
Predictors of HCQ retinopathy
-body weight
-sex
-age
-eGFR
-weight based dose mg/kg
-higher cumulative dose
Risk ranges 1% to >20%
@RheumNow #ACR23 ABST2453 https://t.co/h2tl6vH9M3 https://t.co/8iuRxoVaJ0
Aurelie Najm ( View Tweet)
Very nice to meet @KDAO2011 and @uptoTate as the faculty of Rheum Now @RheumNow tune in, follow them and listen to their interviews on the latest updates from #ACR23 https://t.co/I30wdVoqbd
Dr. Antoni Chan ( View Tweet)
Synovitis in hand #OA
genetic
risk of synovitis predisposed to clinical and radiographic hand OA
@RheumNow #ACR23 https://t.co/aXnXD7UPnv
Bella Mehta bella_mehta ( View Tweet)
Rheumatologist - pharmacist co-management of MTX initiators @GeisingerHealth Philadelphia
Having the dual skill set actually helped with adherence to guidelines vs standard care. Would be great to see how this works with implementation in RA clinics
#ACR23 ABST2484 @RheumNow https://t.co/88R1BYzYn5
David Liew drdavidliew ( View Tweet)
#ACR23 Abstr# 2490 Data supporting aggressive early treatment in #SLE? Multicentre open label RCT in China showed low dose MMF + Pred 0.5mg/kg/d reduced severe flare & lupus nephritis cases vs HCQ + Pred in new onset SLE with high dsDNA but w/o major organ involvement @RheumNow https://t.co/oRlgCaOvXo
Md Yuzaiful Md Yusof ( View Tweet)
Watch: Utility of AI and ChatGPT in Rheumatology
Dr. Kathryn Dao interviews Dr. Richard Stern at the 2023 ACR Convergence meeting in San Diego, CA. #ACR23
https://t.co/SH0TGAdvm8 https://t.co/RHu8bH9YOG
Dr. John Cush RheumNow ( View Tweet)
TM86 #ACR23 @RheumNow
Auricular chondritis, arthritis, axonopathy, high inflamm. Initial Dx: RP
Exam: lymphadenopathy, erythema nodosum, TJC 36, SJC 4 (knees/ankles), decr sensation, asymm reflex, macular rash, nerve thicken
Skin bx: septal panniculitis wo vasc
Dx: leprosy https://t.co/P5QJArRDaA
Eric Dein ( View Tweet)
#Cardiovascular imaging will help to detect #cardiac abnormalities earlier@in #rheumatic #diseases. #ACR23 @RheumNow @ACRheum 14T118 https://t.co/QKCpLWtkUv
Janet Pope ( View Tweet)
🚩Adjunct therapy to treat vasculopathy of MDA5-DM
⭐️Botox heals digital ulcerations and improves Raynaud's (slide 1)
Dr. Katherine Shaw injects Botox for healing recalcitrant ulcerated Gottron's papules (example patient failed nifedipine, sildenafil, pentoxyfylline & while on… https://t.co/4XCvRrzeTL https://t.co/yxUCzS30W1
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
What do we know about IL1 drugs in #OA only a small few stidies prior to CANTOS .
COLCHCINE didnt seem to work
LoDoCO2 post hoc analysis may work? @RheumNow #ACR23 https://t.co/h4oVRppI5S
Bella Mehta bella_mehta ( View Tweet)
Gene signature predicts RA trajectory during pregnancy:
Blood RNAseq *before* pregnancy
🚺 improve during preg: Strong Neutrophil signature
🚺 experience dis worsening:
Strong B cell signature
Needs replication but could have major implications!
@RheumNow #ACR23 ABST2481 https://t.co/gOHwEvOOM6
Aurelie Najm ( View Tweet)
#ACR23 Abstr# 2487 How to reduce PBO response in #SLE trials? Try adding low dose GC as co-primary endpoint. Interim analysis of Phase 2 RCT: SRI-4 + sustained GC dose to ≤5mg/d or ≤BL from Wk16 to 28 was met more in Ianalumab (BAFF-R-i) vs PBO (44% vs 9%) @RheumNow https://t.co/JEnMWKilR6
Md Yuzaiful Md Yusof ( View Tweet)
TM85 #ACR23 @RheumNow
IPF s/p lung transplant p/w diffuse bone pain
Exam: no synovitis, +crackles. Labs: ALP 203
CT chest: stable mycetoma
Xray: periosteal reaction
Dx: vericonazole periosititis
Positive Mucorales PCR, fluoride level 19 (ref <4)
Bone pain improved stopping voric https://t.co/Gt8mOAssvh
Eric Dein ( View Tweet)