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Women with Rheumatic Disease (11.4.2022)
Dr. Jack Cush reviews the news and journal articles from this past week on RheumNow.com. New regulatory decisions about JAK inhibitors and why do women with rheumatic diseases have unfair outcomes?
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Denosumab in erosive hand OA. 12-weekly dosing, primary end-point at 24 weeks.
@RheumNow #ACR22 #LateBreaking
Julian Segan JulianSegan ( View Tweet)
Yazici et al. IA Lorecivivint in Knee OA. 56 week DB-RCT of single injection at time 0. Didn't work. Not for primary endpoint (Pain NRS) or any PRO. @RheumNow #ACR22 Abstr#1639 https://t.co/66KyJW1zVz
Richard Conway RichardPAConway ( View Tweet)
Utamawatin et al. DB-RCT of Triamcinolone 10mg vs 40mg for knee OA. No difference! Wonder if 10mg would be better than saline? @RheumNow #ACR22 Abstr#1890 https://t.co/vcKze7mSf4 https://t.co/ErEkmUN0Wp
Richard Conway RichardPAConway ( View Tweet)
Maksymowych et al. RCT ofAdalimumab for knee OA!? it doesn't work. @RheumNow #ACR22 Abstr#1891 https://t.co/pfPVJ9A1Ex https://t.co/X7sLEaqGvT
Richard Conway RichardPAConway ( View Tweet)
Yazici et al. RCT of IA Lorecivivint for moderate/severe knee OA. CLK/DYRK inhibitor. No effect seen. @RheumNow #ACR22 Abstr#1899 https://t.co/XGQrMmNnSR https://t.co/rSJrT6Hms6
Richard Conway RichardPAConway ( View Tweet)
Bihlet et al. Anti-histamines may reduce structural progression of knee OA. Post-hoc analysis of 2 trials @RheumNow #ACR22 Abstr#1893 https://t.co/RrrelHDz75 https://t.co/Sf7RpjjAaN
Richard Conway RichardPAConway ( View Tweet)
Shanahan et al. RCT of Genicular nerve block for knee OA. It works but temporary, with loss of effect by week 12. @RheumNow #ACR22 Abstr#1892 https://t.co/VySjBGrVeR https://t.co/JNKQeOVB6z
Richard Conway RichardPAConway ( View Tweet)
Ab0577 #ACR22 Sao Paulo Aging & Health (SPAH)
Radius 1/3 BMD enhance fx risk estimates when combined w/ spine (RR 1.4, p=0.03)
For radius+hip or radius+spine/hip, radius DEXA is non-significant - only hip predicted fx
Use radius BMD when hip unattainable- THA/severe OA
@Rheumnow
Eric Dein ericdeinmd ( View Tweet)
QD Clinic - How to Treat Erosive OA (abstract #L05)
61yoWM with bilateral pain/swelling in DIPs. Labs normal, seronegative and Xrays shows evidence of DIP erosive OA.
But what works in EOA? #ACR22
https://t.co/tbIoTg6kxA https://t.co/YcW7TON0En
Links:
Dr. John Cush RheumNow ( View Tweet)
What's the role of MRI in #osteoarthritis?
#ACR22 @RheumNow #acrreview https://t.co/uZEzUSLo88
sheila RHEUMarampa ( View Tweet)
When referring to radiographs in #osteoarthritis, it can be better described as early, advanced or end-stage as it only shows the extent of joint damage accrued over time, not telling us much on the severity of disease - Dr. Scanzello
#ACR22 @RheumNow https://t.co/m7Vdmu6KM6
sheila RHEUMarampa ( View Tweet)
#osteoarthritis pain is complex! @rheumarhyme
🔸pain sensitization - ⬆️responsiveness of peripheral nociceptors
🔸more severe pain on mov't
🔸assoc . w/ synovitis
#ACR22 @RheumNow #acrreview https://t.co/PbQOv6386W
sheila RHEUMarampa ( View Tweet)
2019 Reccs for #OA RX- educate, exercise and weight mgmt is cornerstone . Hyaluronic acid supplementation and stem cell, PRP injx not recc. #acr22 #acrreview @rheumnow https://t.co/v5w84z9eCu
TheDaoIndex KDAO2011 ( View Tweet)
What's the clinical use of imaging in #osteoarthritis?
👉Useful in atypical presentations, NOT required for dx
👉Always consider the view (particularly knees)
👉No evidence in predicting response to non-surgical tx
#ACR22 @RheumNow #acrreview https://t.co/nlRI1dbbud
sheila RHEUMarampa ( View Tweet)
#Exercise does NOT increase the risk for knee replacement but can provide a protective effect - Dr Scanzelloe on #OA @rheumnow #acr22 #acrreview https://t.co/a8Q1FLUvcw
TheDaoIndex KDAO2011 ( View Tweet)
❗Encouraging weight loss in #osteoarthritis is really challenging! @rheumarhyme
But this slide👇 is reassuring and we can use it to motivate our patients.
#ACR22 @rheumnow #acrreview https://t.co/hUa56UfJPA
sheila RHEUMarampa ( View Tweet)
Short-term intra-articular steroids are effective (unclear- long term benefits) - no increase risk for knee replacement with repeat steroid injx #osteoarthritis @rheumnow #acr22 #acrreview https://t.co/MJHXWePF70
TheDaoIndex KDAO2011 ( View Tweet)
National Swedish Hip & Knee OA registry compared outcomes if pts seen in-person (F2F) or digitally (online) in 6946 pts - both groups improved at 3 mos; but digital pts had larger improvement at 3 mos (pain & Function) -- unknown if clinically meaningful https://t.co/yD4zAVpuhh https://t.co/IjqnTjXpbC
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Dr. John Cush RheumNow ( View Tweet)
Retrospective study of 75 knee OA pts w/ SF aspiration and MRI showed Median SF WBC =284, w/ higher SF WBC w/medium/large effusions. Despite this trend, SF WBC did not strongly correlate w/ MRI inflammation (effusions or synovitis) https://t.co/6suIGJNLdW https://t.co/gNd1Dai4SI
Links:
Dr. John Cush RheumNow ( View Tweet)
