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Is IL-6 a potential therapeutic target in neuropsychiatric lupus (NPSLE)? Just published in the Journal of Neuroinflammation- Some interesting findings from the Putterman lab in a murine NPSLE model... https://t.co/7yn2o7ZRxS

Links:

chaim putterman ChaimPutterman ( View Tweet)

brain headache neuro

Neuropsychiatric SLE - 2/3 Improved at 12 Months

d Jack Cush, MD

The management and outcomes of neuropsychiatric systemic lupus erythematosus (NPSLE) can be challenging as there is limited data. 

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Malar,rash,SLE, Lupus

JAMA: SLE Review

d Jack Cush, MD

Drs. Caroline Siegel and Lisa Sammaritano (from HSS in NYC) have published an impressive overview of systemic lupus erythematosus (SLE) in JAMA. This timely, well-written review covers the many complexities of this multi-organ disorder that affects nearly 3.4 million people worldwide.

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Polycyclic Aromatic Hydrocarbons Increase Lupus Risk A case-controlled study shows environmental exposure to polycyclic aromatic hydrocarbons (PAH) may increase the risk of developing systemic lupus erythematosus (SLE). https://t.co/04MPWwQlUr https://t.co/iTf6EmKLId

Links:

Dr. John Cush RheumNow ( View Tweet)
10 SLE pts w/ ITP and thrombocytopenia were Rx w/ belimumab IV (age 34.3 ± 14 yrs). Overall response rate of thrombocytopenia was 90%, w/ improvement in platelets, lymphocyte count, Hgb, dsDNA, C3, C4 and SLEDAI https://t.co/5U7mHoY0fg https://t.co/oOqUJqUNgl

Links:

Dr. John Cush RheumNow ( View Tweet)
Neuropsychiatric (NP) Sxs compared in SLE (n 609), controls (463) & IA patients (489). Hallucinations and severe headache were most directly attributable to NP-SLE. https://t.co/JWbyHmpWcq https://t.co/gBubdEjq63

Links:

Dr. John Cush RheumNow ( View Tweet)
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1/600 Falls May Die (4.5.2024)

d Jack Cush, MD

Dr. Jack Cush reviews the news and Journal reports from this past week on RheumNow.com -  including problems w/ falls, pain and treatment of Dupuytren’s contractures.

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#RNL2024 @RheumNow @Bweber04 Asymptomatic Lupus has higher rate of atherosclerosis at all age grps 35-44 yo F with SLE: 50X increased risk of MI compared to healthy pts in Framingham RA pts at 1.5x risk of CVD https://t.co/wL4U8Gh5JM

Links:

Dr. John Cush RheumNow ( View Tweet)

pollution,smoke

Polycyclic Aromatic Hydrocarbons Increase Lupus Risk

d Jack Cush, MD

A case-controlled study shows environmental exposure to polycyclic aromatic hydrocarbons (PAH) may increase the risk of developing systemic lupus erythematosus (SLE). 

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epigenetics,skin,autoimmune

Epigenetics and Autoimmune Skin Disease

d EurekAlert!

The central dogma proposed that genetic information predominantly transfers from DNA to RNA during gene expression to make a functional product protein. This absolute theory has been debunked because of the influence of the environment on how genes are transcribed.

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Autoimmune dz pts have higher risk of macular degeneration. Cleveland Clinic study of 200K AMD vs controls, finds: - SLE (RR 1.73) - Scleroderma (1.65) - Psoriasis (1.48) - Vasculitis (1.48) - RA (1.4) - UC &CD (~1.42) - Sarcoid (1.42) https://t.co/RrXaaqz3Aw https://t.co/9dGoGRCBYu

Links:

Dr. John Cush RheumNow ( View Tweet)
FINAL 2020 Podcast Graphic

Activity & Pain Tolerance (3.29.2024)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com, including where you should sit in clinic and why you should worry about secondary Sjogren's in RA.

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pregnancy,embryo,fetal

Higher Rates of Childlessness in Rheumatic Diseases

d Jack Cush, MD

A large Finnish population study shows that several rheumatic diseases may impair reproduction and pregnancy outcomes, with significantly higher rates of childlessness or fewer children overall for women.

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Series of Chronic Cutaneous Lupus responding to anifrolumab. 6 pts (4 DLE, 2 CCLE) betw 37-66 yrs old w/ Dz duration 10.5 yrs, 4 w/ SLE, all refractory to multiple therapies Rx w/ ANIF w/ Skin benefit. 1 developed herpes, 1 had worsening of nephritis https://t.co/6imLq3TDMu https://t.co/BMoIQhRtYs

Links:

Dr. John Cush RheumNow ( View Tweet)
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Naysayers & Disrupters (3.22.2024)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from the past week - including a few contrary reports on infection, seropositivity and plasmapheresis.

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91 #SLE pts w/ no baseline synovitis, underwent Ultrasound exams. 10 yrs later, 31 had clinical progression of arthritis. Pts w/ progression, 75% had baseline subclinical synovitis on US vs without progression 77% did NOT have an abnormal US at baseline https://t.co/MN9wkNgsQV https://t.co/ozgvjFI531

Links:

Dr. John Cush RheumNow ( View Tweet)
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Ides of March (3.15.2024)

d Jack Cush, MD

Dr. Jack Cush has advice for Caesar and the superstitious, and covers pregnancy, platelets, dialysis and vaccinations in Lupus.

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SLE & remission on hemodyalysis (HD)? Cohort of 137 pts starting HD & the # off SLE Rx increased w/ time: 67% (HD start), 76.0% (1st Yr), 83% at 3 yrs (less w/ younger). Lupes flares most in 1st yr of HD; @12 mos 52% minor and 12% had severe flares. https://t.co/8N7CJWkIUY https://t.co/48eOclzrJH

Links:

Dr. John Cush RheumNow ( View Tweet)
Chinese SLE registry study of 350 SLE-TP (low plts) pts - 55% were aPL Ab+ (who had lower Plts @baseline (61K vs 76k). aPL+ SLE-TP pts w/ higher relapse rate (58% vs. 44%, P=0.009) & lower complete response rate. > more aPLs--> increased relapse rates https://t.co/Mb2YhsniVJ https://t.co/92QRWICcB4

Links:

Dr. John Cush RheumNow ( View Tweet)
Vaccinations NOT linked to SLE risk. 17 studies (45 million) w/ F/U up to 2 yrs. No signif SLE risk: - all vaccinations (OR=1.1; CI 0.86–1.5) - HBV vax (OR=2.11; 1.11-4) - HPV (OR=1.4; 0.88–2.3) - Flu (OR=0.96; 0.82–1.1) - COVID (OR=0.44; 0.18–1.2) https://t.co/YpxSYL97DM https://t.co/hsytm9UpDC

Links:

Dr. John Cush RheumNow ( View Tweet)

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