All News

RheumNow Podcast square

Fever Pitch (7.15.2022)

Jack Cush, MD

Dr. Jack Cush reviews the new studies and drug approvals and new insights into febrile disorders from the past week on RheumNow.com

Read Article
question-mark-1872634_640.jpg

Still’s Disease FAQs

Jack Cush, MD

What is the classic 'triad' of Still's disease? Does it affect males and females equally? What are typical lab findings? Which drugs are effective at treating Still's, and as importantly, which ones are not? What about complications? Read on for these and other FAQs regarding Still's disease.

Read Article
Biomarker,genes

MRP8/14 as a Biomarker in Systemic Juvenile Idiopathic Arthritis

Jack Cush, MD

A large cohort study of children with febrile disorders has demonstrated the diagnostic utility of Myeloid-related protein 8/14 (MRP8/14) in diagnosing systemic JIA patients (SJIA) in clinical practice.

Read Article
QD Clinic - Stills (or Not); A Wife's Letter A letter from the wife of a hospitalized febrile patient says it all. But, is this Still's disease or not? https://t.co/MpPbDU9ZTB https://t.co/BqpusOKKLq

Links:

Dr. John Cush RheumNow ( View Tweet)
Still’s Disease FAQs What is the classic 'triad' of Still's disease? Does it affect males and females equally? What are typical lab findings? Which drugs are effective at treating Still's, and which ones are not? What about complications? Read on... https://t.co/rsFHNPwo9Y https://t.co/AUP1GpbDaN

Links:

Dr. John Cush RheumNow ( View Tweet)
New download available! We're providing an introduction to Still's Disease. https://t.co/67XzncaUef https://t.co/gaMNGk0grn

Links:

Dr. John Cush RheumNow ( View Tweet)

Proposed investigations (findings) in the diagnosis of Stills disease: - CRP, ESR, Ferritin (high) - W/U for infection, cancer (negative) - Serologies (negative) - consider Imaging (CXR, CT, US, PET) https://t.co/ByNSq8YACC https://t.co/BdhfRjPA6L

Links:

Dr. John Cush RheumNow ( View Tweet)
MRP8/14 as a Biomarker in Systemic Juvenile Idiopathic Arthritis A large cohort study of children with febrile disorders has demonstrated the diagnostic utility of MRP8/14 in diagnosing systemic JIA patients (SJIA) in clinical practice. https://t.co/Gma3h9Iuqn https://t.co/7GOeES4bbA

Links:

Dr. John Cush RheumNow ( View Tweet)
QD Clinic - Stills (or Not) with Hives What do you think? 40 yr. woman with fevers, hives, and LFTs. https://t.co/IZNnWzerOL https://t.co/sUGPuy2tKC

Links:

Dr. John Cush RheumNow ( View Tweet)
NEJM Case - 17-Year-Old Girl with Fever and Cough and B/L lower lobe infiltrates. 3 wk hx started w/ conjunctivitis, SOB, Cough fever myalgia & knee pain. No rash. T 38.5°C, W 11.5, H/H 6.9/21, P526k, CRP 77mg/L, UA 2+ protein, neg COVID tests. https://t.co/VOiW7DIdBR https://t.co/1GWA2gAgeK

Links:

Dr. John Cush RheumNow ( View Tweet)
Worldwide metanalysis of FUO shows most common infections to be Mycobacterium tuberculosis (34%), brucellosis (10%), endocarditis (7.5%), abscesses (7%), herpesvirus (CMV,EBV 7%), pneumonia (6%), URI (6%), enteric fever (5%) https://t.co/RPMb1kYEI9 https://t.co/E0lrizOUkF

Links:

Dr. John Cush RheumNow ( View Tweet)
When to think beyond infection in recurrent fever??Join us to learn a clear approach to fever and auto inflammatory disorders from expert faculty @bhat_chandrika at #cusp @rakshay_shetty @PedRheum @PeriodicFeverUK @LatikaGupta_ @DrPujaMehta1 https://t.co/roMVbBDaNK
RCHPediatrics RchPediatrics ( View Tweet)
About 1 in 7 systemic JIA are "refractory" to standard Rx. Could the definition be active systemic or arthritic disease, despite IL-1 or IL-6 inhibitors? It could also include pts developing MAS, ILD or amyloidosis. Still, there are many Rx options. https://t.co/VBeHhHEtqW https://t.co/67c5Emo337

Links:

Dr. John Cush RheumNow ( View Tweet)
#AOSD cause is unknown, but matched case control study suggests signif link to Stressful life events (OR 2.56) & nonsignificant risk trending towards coal dust exposure (OR 3.0), allergy prior to onset (OR 2.67) & oral contraceptive use (OR 2.0) https://t.co/Saa4gEbzKS https://t.co/87RKgojmGZ

Links:

Dr. John Cush RheumNow ( View Tweet)
Proposed investigations (findings) in the diagnosis of Stills disease: - CRP, ESR, Ferritin (high) - W/U for infection, cancer (negative) - Serologies (negative) - consider Imaging (CXR, CT, US, PET) https://t.co/l3yqAx6PA0 https://t.co/Sg7okwKHaw

Links:

Dr. John Cush RheumNow ( View Tweet)
Guidelines for MAS complicating Systemic JIA: Dx is based on: - Fever in sJIA with ^ ferritin > 684, plus - Any 2 of these: elevated PLTs, AST, Triglycerides or low Fibrinogen https://t.co/aIEvxRYZca https://t.co/DYpLHxRCzI

Links:

Dr. John Cush RheumNow ( View Tweet)
Cyclic GMP–AMP synthase (cGAS) engages stimulator of interferon genes (STING) to trigger inflammatory cytokines & type I interferons. cGAS–STING activation by genomic or mitochondrial self DNA implicated in autoinflammatory & autoimmune dz https://t.co/7CEFt9wLrl https://t.co/HpHhjJOATd

Links:

Dr. John Cush RheumNow ( View Tweet)
Five Mistakes When Diagnosing Still’s Disease AOSD is likely to be the adult continuum of systemic-onset juvenile arthritis (sJIA) and hence, frequently affects young men and women below the age of 35 years. https://t.co/C9kUOpFIlc https://t.co/82GIA7hSJl

Links:

Dr. John Cush RheumNow ( View Tweet)
Solving Still’s Disease Still's disease is the most common rheumatic cause of unknown fever in adults. This series covers the definition, history, epidemiology, key manifestations and labs, diagnostic criteria, and more. https://t.co/YqpSW6T3El https://t.co/vwehTCm4aN

Links:

Dr. John Cush RheumNow ( View Tweet)
QD Clinic - Stills (or Not) MAS off of Tocilizumab https://t.co/YGEifF5X8K https://t.co/719RjYzbE3

Links:

Dr. John Cush RheumNow ( View Tweet)
How well do you know this week's rheumatology news?
Take the rheumIQ quiz
Take the RheumIQ Quiz

×