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FDA Panel Rejects Tanezumab for Osteoarthritis

d Jack Cush, MD

A two day FDA review by the Drug Safety and Risk Management and Arthritis Advisory Committees has yielded a 19-1 vote against the approval of tanezumab, a nerve growth factor inhibitor, for use in osteoarthritis (OA).

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News Feature: Are You a Super Rheum? https://t.co/LsGpFNXlkp https://t.co/Q9iojEQNqL

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RCT shows Stepped Exercise Program to be effective in Knee Osteoarthritis. VAMC study of 345 knee OA pts given either STEP-KOA (internet based progr) or an arthritis education (control). WOMAC scores at 9 mos were 6.8 points lower in the STEP-KOA group.https://t.co/EuoPyJkTif

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RheumNow Podcast – Great Associations (3.19.2021)

d Jack Cush, MD

Dr. Jack Cush rants on the journal reports, news and FDA actions featured this past week on RheumNow.com.

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β-blockers may lower risk of knee OA and knee pain. Matched cohort study of 100K pts from UK registry shows β-blocker use associated with 10-12% lower risk of knee OA, knee pain & hip pain consultations, moreso w/ Propranolol and atenolol (9-22%) https://t.co/38RoeP1Pmw

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Intraarticular Steroids in OA - They Dont work & Not Safe https://t.co/fB9SDFMVgf https://t.co/u14ibcRpvZ

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RheumNow Podcast – Sweet Lies or Hard Truths? (2.26.2021)

d Jack Cush, MD

Dr. Jack Cush reviews and discusses the news and Journal reports from the past week on RheumNow.com.

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News Feature: Diagnosis & Treatment of Osteoarthritis Reviewed Katz, Arant and Loeser have published a comprehensive open-read overview of OA of the hip and knee in JAMA; underscoring the impact, advances, disappointments and guidelines put forth https://t.co/VVnUk02KiP https://t.co/97dFC56Jcb

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Dr. John Cush RheumNow ( View Tweet)
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Diagnosis & Treatment of Osteoarthritis Reviewed

d Jack Cush, MD

Katz, Arant and Loeser have published a comprehensive open-read overview of osteoarthritis (OA) of the hip and knee in JAMA; underscoring the impact, advances, disappointments and guidelines put forth. 

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Population based study of smoking cessation & risk of TKR in knee OA. TKR higher in recent quitters (26.7/1000PY vs 17.4/1000PY in smokers). adjusted HR=1.30 (95%CI:1.05-1.59). TKR risk was higher among quitters with weight gain (HR=1.42) https://t.co/6onQWQeFcI

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SF analysis usually confirms dx, but changes dx 14%. 264 SF samples showed MSU crystals in 89% gout, 9% of CPPD pts. CPP crystals found in 54% of CPPD, 43% of OA & 7% of gout pts. Ca hydroxyapatite seen 1/3 RA, 1/2 OA & 2/3 CPPD https://t.co/B8UkHagXK3 https://t.co/UTncLo6Fyu

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On March 24, 2021 the FDA Arthritis Advisory Committee and Drug Safety .... Committees will meet online to will discuss biologics license application, for tanezumab, from Pfizer, for the proposed treatment of moderate to severe osteoarthritis in adults https://t.co/NSlutqdHzu

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RWCS Highlights - Day 4 from Dr. Rachel Tate ( @uptotate) -Novel Therapies Year in Review (RA, SLE, OA) -Novel concepts in Pediatric Rheumatology -TeleRheumatology Update: Post-COVID, Pre-?? https://t.co/JoTV25suxD https://t.co/Id19zgRT37

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RWCS Highlights - Day 3

d Rachel Tate, DO

Day 3 report from the 2021 RWCS meeting in Maui (and virtually) includes pearls from the PsA 2020 Year in Review; fact vs. fiction on evidence based medicine: diet and rheumatic diseases; hot topics in allergy/immunology; and pediatric rheumatology highlights.

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NSAIDs in Osteoarthritis: Study Suggests Need for New Look Knee osteoarthritis (OA) patients using NSAIDs showed greater loss of medial minimum joint space width than did others taking other drugs, registry data indicated. https://t.co/KNbAnNOkva https://t.co/s9mMmAR6TD

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NSAIDs in Osteoarthritis: Study Suggests Need for New Look

d Jack Cush, MD

Knee osteoarthritis (OA) patients using nonsteroidal anti-inflammatory drugs (NSAIDs) showed greater loss of medial minimum joint space width than did others taking other drugs, registry data indicated.

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QD Clinic - Chronic Monarthritis Treatment Considerations on Chronic Monarthritis https://t.co/7VmH1skHhb

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OpenSAFELY analysis shows that NSAIDs safe w/ COVID. Study 1: 1/2 million NSAID users vs ~2 mill non-users found no difference in COVID-19 death (HR 0.96); Study 2: 1.7 million RA/OA pts, 10% on NSAIDs had a lower risk of COVID-19 death (HR 0.78) https://t.co/1f3JBmaf2e

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Download Available-- Osteoarthritis vs. Rheumatoid Arthritis https://t.co/qvVEcKqNAM

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RheumNow Podcast – Don’t Hold the Benlysta, Take the Vaccine (1.22.2021)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com, with more than a dozen items to discuss on this week's podcast.

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