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RheumNow Podcast – Upadacitinib Wins in PsA (4.2.2021)

Jack Cush, MD

Dr Jack Cush reviews the news and Journal reports and takes "Back Talk" questions from viewers.

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Hypertension Unaffected by Urate Lowering Therapy

Jack Cush, MD

Does uric acid contribute to the risk of hypertension (HTN)?  A recent cohort trial shows that allopurinol in young adults does not sufficiently lower blood pressure (BP).

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RheumNow Podcast – Great Associations (3.19.2021)

Jack Cush, MD

Dr. Jack Cush rants on the journal reports, news and FDA actions featured this past week on RheumNow.com.

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Apremilast Equals MTX in Palmoplantar Psoriasis

Jack Cush, MD

Palmoplantar psoriasis (PPP) is a therapeutically challenging variant of psoriasis; nonetheless, a prospective, randomized, active-controlled trial from India suggests that apremilast is effective and safe in patients with PPP.

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MDA-5 Antibodies and Juvenile Dermatomyositis

Jack Cush, MD

A multicentre, retrospective study examined MSA profiles (by immunoprecipitation) from 96 juvenile idiopathic inflammatory myopathies (JIIM) at nine pediatric rheumatology centres in Japan. MSA were found in 85 of 96 cases with over 90% of patients having one of the following three MSA

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Higher Lupus Mortality Among Minority Populations

Jack Cush, MD

The February 19th MMWR reports that higher mortality rates in certain patients with systemic lupus erythematosus (SLE); data based on recent San Francisco County statistics showing a four fold higher mortality among Asian and Hispanic/Latina females with SLE.

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IVIg in MIS-C

Jack Cush, MD

Among children with multisystem inflammatory syndrome (MIS-C), treatment with IVIG and methylprednisolone vs IVIG alone was associated with a more favorable fever course. MIS-C is a rare but serious pediatric condition associated with COVID-19 where different body parts can become inflamed, including the heart, lungs, kidneys, brain, skin, eyes, or gastrointestinal organs.

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Factors Predictive of SLE Flare After HCQ Taper/Discontinuation

MedPage Today

The benefits of hydroxychloroquine in lupus are many, but if you were to withdraw HCQ? A recent study of five Canadian cohorts, suggests that certain baseline variables, including age, race, and steroid use,  were predictive of flare in patients with SLE who tapered or discontinued treatment with hydroxychloroquine.

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Analysis of 8416 pts w/ Kawasaki disease (KD) shows older and younger children differ. <10% were under 6 mos, 78%) were 6 mos-4yrs; 11% 5 to 9 yrs. Younger KD had more incomplete KD, coronary aneurysms, while older had more delayed diagnoses, more fever https://t.co/NkSmfg38ru

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Dr. John Cush RheumNow ( View Tweet)

Very high levels of IL-18 IL-18 (> 10 000 pg/ml) is associated with Macrophage Activation syndrome (with systemic JIA) as well as primary and secondary Hemophagocytic lymphohistiocytosis (HLH) https://t.co/dotoaYbuPd

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Dr. John Cush RheumNow ( View Tweet)

Common mucocutaneous findings in 35 kids w/ MIS-C & COVID: 1) conjunctival injection (21), palmoplantar erythema (18), lip hyperemia (17), periorbital erythema/edema (7), strawberry tongue (8), & malar erythema (6) https://t.co/mcSOXtXaEh

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Dr. John Cush RheumNow ( View Tweet)

1975: Nixon & Bresnev, in effort of medical diplomacy, cooperated on JRA trials. (Fact: Stalin's personal physician was a rheumatologist.) Dr. Steven's shares an interesting historical slide about this collaboration. #RWCS2021 #RWCS @RWCSmtg @RheumNow https://t.co/Px71qfqDcy
Dr. Rachel Tate uptoTate ( View Tweet)
Some statistics regarding pediatric rheumatologists in the US and abroad. Here in the US we have under 30 fellowship options, 448 pediatric rheumatologists in 2019 (and growing), and patients/families are driving on ave 42.8 miles to get care. #RWCS2021 #RWCS @RheumNow @RWCSmtg https://t.co/RhTroEKcwN
Dr. Rachel Tate uptoTate ( View Tweet)
A serious shortage of pediatric rheumatologists in the USA, where we need at least 1 ped rheum per 400,000 population. @RWCSmtg https://t.co/o8XCkjUOaN
Dr. John Cush RheumNow ( View Tweet)
CARRA was established in 2000 to further pediatric Rheumatology through research and registries @RWCSmtg https://t.co/drXGz23QyN
Dr. John Cush RheumNow ( View Tweet)
Milestone achievements of the pediatric Rheumatology collaborative study group @RWCSmtg https://t.co/OGXd2YWj5A
Dr. John Cush RheumNow ( View Tweet)
Dr. Anne Stevens lecturing at @RWCSmtg on the history of pediatric Rheumatology. Sir Eric Bywaters was the Father of meeting day pediatric Rheumatology @RWCSmtg https://t.co/iZtPfgoyxa
Dr. John Cush RheumNow ( View Tweet)
Dr George F Still, among the first to write about children with arthritis, pediatric Rheumatology, in 1898, with his description of 22 kids with arthritis. @RWCSmtg https://t.co/Y6DOzooFjZ
Dr. John Cush RheumNow ( View Tweet)

Defects in NLRC4 inflammasome can drive IL 18 production in systemic JIA. @RWCSmtg https://t.co/ffzODTXd52

Dr. John Cush RheumNow ( View Tweet)
IVIg in MIS-C Among children with multisystem inflammatory syndrome (MIS-C), treatment with IVIG and methylprednisolone vs IVIG alone was associated with a more favorable fever course. https://t.co/iCyJd3bbao https://t.co/edgVLpMP5a

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Dr. John Cush RheumNow ( View Tweet)
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