Article
While it is often said there is a negative association between gout and rheumatoid arthritis (RA), cases of coexistent disorders are uncommonly seen. A recent VA study describes 121 patients whith both RA and gout.
All News
Article
The VITAL study is a VA registry that has shown that both systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) patients carry higher odds of both premature and extremely premature atherosclerotic cardiovascular disease and its consequences.
Article
Two recent reports further characterize the newly described, Kawasaki-like, syndrome affecting children with COVID-19 infections.
The NEJM describes the childhood syndrome as having Kawasaki’s disease, fever, toxic shock syndrome, acute abdominal conditions, and encephalopathy; hence the label Childhood Multisystem Inflammatory Syndrome. The disorder emerged in late April 2020, first in the U.K., and then similar cases were reported from many other countries. The CDC named this multisystem inflammatory syndrome in children (MIS-C).
Article
Dr Jack Cush reviews the news and journal articles from the past week on RheumNow.com
Article
For years, rheumatologists would rather fight to stay on a TNF inhibitor (TNFi) than switch to a non-TNFi biologic when rheumatoid arthritis (RA) therapy fails.
Dr. John Cush
Tweet
Rheumatologist Question: early on, what do you tell your RA patient their chance of future drug free remission?
Peter Nash
Tweet
Rheumatoid Arthritis: Pathogenesis, Prediction and Prevention – An Emerging Paradigm Shift https://t.co/uNDsLmgaN7
#RA #prevention #Rituximab - nice article, still think if repeated Ritux to eliminate pathogenic abs would significantly prevent RA
Dr. John Cush
Tweet
Claims data study of nearly 3 million receiving influenza vaccination shows an increased risk of subsequent subdeltoid bursitis, but incredibly low with an attributable risk was 7.78 additional bursitis per 1 million vaccinated.https://t.co/qtzd8pWk4O
Dr. John Cush
Tweet
Pneumonia vaccination of 21461 RA pts in UK Clinical Practice Research Datalink (2000-18) finds 38.2% vaccinated; 44.3% ≥65 years, 66.4% female; 36.5% vaccinated prior to starting csDMARDs, moreso in elderly. VAX increased over time (esp 2003 to 2007) https://t.co/QTedUMWvE0
Dr. John Cush
Tweet
A Genetic Probability tool used to calculate risk of rheum Dz in 3 pt cohorts (1211 eMERGE, 245 Partners & 243 early inflam arthritis. Dx AUc: 0.69, 0.81 & 0.84. Likely dx made in 64% & r/o in 45%. ?Could be used to improve Dx accuracy in clinical practice?https://t.co/JiRIxtx3j5
Dr. John Cush
Tweet
Schulz-Koops reports 2 #RA patients Rx with RTX who died from COVID pneumonia and ARDS. Both were older, had comorbidities (COPD, HTN, OP) and had received last RTX either 2 wks and 6 mos before COVID infection onset; both had nl IgG levels https://t.co/j043Tggdbg
ARD & RMD Open
Tweet
Increased rate of hospital #COVID-19 cases associated with some but not all chronic #inflammatory or #autoimmune conditions compared with reference population.
The risks seem to depend on age, the specific disease and previous therapies.
https://t.co/8j6R0oO99y https://t.co/n3cEXFx9Kk
Eric Topol
Tweet
Now with ~1,000 children and adolescents with multi-inflammatory syndrome in children (MIS-C), it can be considered a new disease. Today new @NEJM reports and an editorial on its status. I've made a summary of some key points to start https://t.co/1HSWSvumpv
Dr. John Cush
Tweet
60,596 RA Medicare patients with MBDA testing showed in those not taking biologic/JAK inhibitor Rx, the odds of adding new Rx was 9.0% (with a low MBDA), 11.8% (moderate MBDA), and 19.7% (high MBDA, p < 0.0001). Higher MBDA yields more Drug switches https://t.co/Tu7jChQi06
Dr. John Cush
Tweet
Global prevalence of juvenile idiopathic arthritis is ~ 2,069,246 < 16 year olds compared with a prevalence of ~ 206,931 < 16 year olds with juvenile SLE. JIA is 10 times more prevalent than lupus in children < 16yrs. https://t.co/2xvhg59c1J
Dr. John Cush
Tweet
Retrospective study of 2369 patients with Kawasaki disease examined different doses of aspirin showing lower ASA doses of 20–29 mg/kg/day was as effective as 30–50 mg/kg/day in preventing coronary artery aneurysms with no change in IVIG resistance https://t.co/kJgkSSpjyw
Dr. John Cush
Tweet
Study of 1362 #RA patients given TNF inhibitors, abatacept, tocilizumab between 2011-17 finds TCZ had best survival regardless of age; ABA had lowest D/C for adverse events & disease activity improved more with TNFi. https://t.co/7RRO9M4Wf0
Dr. John Cush
Tweet
Tocilizumab may be effective in refractory ocular-, neuro-, vasculo-Behcet's. Study of 47 Behcet's pts Rx w/ TCZ - good at ocular (24/25), CNS (6/6), vascular (7/7) & amyloidosis(2/2) but less effective w/ oral/genital (8/21), skin (6/14) or joints (4/11) https://t.co/lKY8D706bi
Dr. John Cush
Tweet
TNFi, ABA, TCZ Retention rates looked at in 1362 RA according to age. For < 65 years, 3-year retention was best for TCZ 69%. For pts 65–74 years, retention rates highest for TCZ . For ≥ 75 years, 3-year retention rates best for ABA & TCZ (63% & 58%). https://t.co/7RRO9M4Wf0
Dr. John Cush
Tweet
Comparison of elderly-onset (>60yrs) #RA (EORA) to younger-onset (YORA) finds significantly more treatment resistant synovitis and Xray progression in EORA pts with worse overall prognosis compared to YORA (clinical, UA, and pathology). https://t.co/17XSz3Ilap